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Nial J. Wheate
Researcher at University of Sydney
Publications - 95
Citations - 6802
Nial J. Wheate is an academic researcher from University of Sydney. The author has contributed to research in topics: Platinum & Drug delivery. The author has an hindex of 33, co-authored 84 publications receiving 5732 citations. Previous affiliations of Nial J. Wheate include Strathclyde Institute of Pharmacy and Biomedical Sciences & University of New South Wales.
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The status of platinum anticancer drugs in the clinic and in clinical trials.
TL;DR: The status of platinum anticancer drugs currently approved for use, those undergoing clinical trials and those discontinued during clinical trials are updated, and the results in the context of where the field will develop over the next decade are discussed.
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The side effects of platinum-based chemotherapy drugs: a review for chemists
TL;DR: Patients are commonly co-prescribed additional non-chemotherapy based drugs to treat the side effects which can include antiemetics, antibiotics and myeloid growth factors, mannitol, propafenone, saline hyperhydration, magnesium supplements, monoclonal antibody cytokine blockers, and antioxidants.
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Gold Nanoparticles for the Improved Anticancer Drug Delivery of the Active Component of Oxaliplatin
Sarah Brown,Paola Nativo,Jo-Ann Smith,David Stirling,Paul R. Edwards,Balaji Venugopal,David J. Flint,Jane A. Plumb,Duncan Graham,Nial J. Wheate +9 more
TL;DR: In this paper, the active component of the cancer drug oxaliplatin was tethered to a gold nanoparticle for improved drug delivery and the platinum-tethered nanoparticles were examined for cytotoxicity, drug uptake, and localization in the A549 lung epithelial cancer cell line and the colon cancer cell lines HCT116, HCT15, HT29, and RKO.
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The potential of cucurbit[n]urils in drug delivery
TL;DR: The potential use of cucurbiturils in drug delivery in the context of getting a new drug into clinical trials is examined and what further research is needed in this area is discussed.
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Multi-nuclear platinum complexes as anti-cancer drugs
TL;DR: In this article, a review of the development of multi-nuclear platinum complexes as anti-cancer agents is presented, with the purpose of providing an insight into the benefits of, and reasons for, their success.