Nicholas B. Allen

Bio: Nicholas B. Allen is an academic researcher from University of Oregon. The author has contributed to research in topics: Anxiety & Poison control. The author has an hindex of 72, co-authored 409 publications receiving 22281 citations. Previous affiliations of Nicholas B. Allen include University of Western Australia & Royal Melbourne Hospital.

Center for Epidemiologic Studies Depression Scale (CES-D) As a Screening Instrument for Depression Among Community-Residing Older Adults

Abstract: The efficacy of the Center for Epidemiologic Studies Depression Scale (CES-D) as a screener for clinical depression was examined in a sample of 1,005 community-residing adults (age range = 50-96). Presence of a depressive disorder was determined by diagnostic interview. Analyses revealed that neither age, gender, cognitive impairment, functional impairment, physical disease, nor social desirability had a significant negative effect on the psychometric properties or screening efficacy of the CES-D. These results indicate that there was no significant degradation in the ability of the CES-D to screen for depression among community-residing elderly adults. This conclusion must be tempered by the fact that the sample did not include participants with the more disabling forms of cognitive or functional impairment and physical illness.

So depression is an inflammatory disease, but where does the inflammation come from?

Abstract: We now know that depression is associated with a chronic, low-grade inflammatory response and activation of cell-mediated immunity, as well as activation of the compensatory anti-inflammatory reflex system. It is similarly accompanied by increased oxidative and nitrosative stress (ON these include psychosocial stressors, poor diet, physical inactivity, obesity, smoking, altered gut permeability, atopy, dental cares, sleep and vitamin D deficiency. The identification of known sources of inflammation provides support for inflammation as a mediating pathway to both risk and neuroprogression in depression. Critically, most of these factors are plastic, and potentially amenable to therapeutic and preventative interventions. Most, but not all, of the above mentioned sources of inflammation may play a role in other psychiatric disorders, such as bipolar disorder, schizophrenia, autism and post-traumatic stress disorder.

The Impact of Intensive Mindfulness Training on Attentional Control, Cognitive Style, and Affect

Abstract: To evaluate the impact of an intensive period of mindfulness meditation training on cognitive and affective function, a non-clinical group of 20 novice meditators were tested before and after participation in a 10-day intensive mindfulness meditation retreat. They were evaluated with self-report scales measuring mindfulness, rumination and affect, as well as performance tasks assessing working memory, sustained attention, and attention switching. Results indicated that those completing the mindfulness training demonstrated significant improvements in self-reported mindfulness, depressive symptoms, rumination, and performance measures of working memory and sustained attention, relative to a comparison group who did not undergo any meditation training. This study suggests future directions for the elucidation of the critical processes that underlie the therapeutic benefits of mindfulness-based interventions.

疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A

Abstract: 抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

Using Multivariate Statistics

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Pattern Recognition and Machine Learning

Abstract: Probability Distributions.- Linear Models for Regression.- Linear Models for Classification.- Neural Networks.- Kernel Methods.- Sparse Kernel Machines.- Graphical Models.- Mixture Models and EM.- Approximate Inference.- Sampling Methods.- Continuous Latent Variables.- Sequential Data.- Combining Models.