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Nicholas E. Geacintov
Researcher at New York University
Publications - 459
Citations - 16216
Nicholas E. Geacintov is an academic researcher from New York University. The author has contributed to research in topics: DNA & Nucleotide excision repair. The author has an hindex of 63, co-authored 453 publications receiving 15636 citations. Previous affiliations of Nicholas E. Geacintov include Memorial Sloan Kettering Cancer Center & Weizmann Institute of Science.
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Journal ArticleDOI
Error-free and error-prone lesion bypass by human DNA polymerase κ in vitro
Yanbin Zhang,Fenghua Yuan,Xiaohua Wu,Mu Wang,Mu Wang,Olga Rechkoblit,Olga Rechkoblit,John-Stephen Taylor,John-Stephen Taylor,Nicholas E. Geacintov,Nicholas E. Geacintov,Zhigang Wang +11 more
TL;DR: It is shown that human Polκ is a novel lesion bypass polymerase in vitro and its response to damaged DNA templates suggests that Polκ plays an important role in both error-free and errorproneLesion bypass in humans.
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Two-polymerase mechanisms dictate error-free and error-prone translesion DNA synthesis in mammals
Sigal Shachar,Omer Ziv,Sharon Avkin,Sheera Adar,John P. Wittschieben,Thomas Reißner,Stephen G. Chaney,Errol C. Friedberg,Zhigang Wang,Thomas Carell,Nicholas E. Geacintov,Zvi Livneh +11 more
TL;DR: Results highlight the central role of polζ in both error‐prone and error‐free TLS in mammalian cells, and show that bypass of a single lesion may involve at least three different DNA polymerases, operating in different two‐polymerase combinations.
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Nmr solution structures of stereoisomeric covalent polycyclic aromatic carcinogen-dna adducts : principles, patterns, and diversity
Nicholas E. Geacintov,Monique Cosman,Brian E. Hingerty,Shantu Amin,Suse Broyde,Dinshaw J. Patel +5 more
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Effect of Magnetic Field on the Fluorescence of Tetracene Crystals: Exciton Fission
TL;DR: In this article, it was shown that a magnetically sensitive coupling of singlet states to a double-triplet-exciton state at 2.40 eV is an important channel for radiationless decay in crystalline tetracene above 160.
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Solution conformation of the major adduct between the carcinogen (+)-anti-benzo[a]pyrene diol epoxide and DNA.
Monique Cosman,Carlos de los Santos,Radovan Fiala,Brian E. Hingerty,Suresh B. Singh,Victor Ibanez,Leonid A. Margulis,David Live,Nicholas E. Geacintov,Suse Broyde,Dinshaw J. Patel +10 more
TL;DR: The solution structure centered about the BP covalent adduct site in the (BP)G.C 11-mer duplex is determined by incorporating intramolecular and intermolecular proton-proton distance bounds deduced from the NMR data sets as constraints in energy minimization computations.