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Nicholas E. Houstis
Researcher at Harvard University
Publications - 29
Citations - 12011
Nicholas E. Houstis is an academic researcher from Harvard University. The author has contributed to research in topics: Heart failure with preserved ejection fraction & Exercise intolerance. The author has an hindex of 13, co-authored 26 publications receiving 9750 citations. Previous affiliations of Nicholas E. Houstis include Massachusetts Institute of Technology & Broad Institute.
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Journal ArticleDOI
PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes
Vamsi K. Mootha,Cecilia M. Lindgren,Cecilia M. Lindgren,Karl-Fredrik Eriksson,Aravind Subramanian,Smita Sihag,J. Lehar,Pere Puigserver,Emma Carlsson,Martin Ridderstråle,Esa Laurila,Nicholas E. Houstis,Mark J. Daly,Nick Patterson,Jill P. Mesirov,Todd R. Golub,Todd R. Golub,Pablo Tamayo,Bruce M. Spiegelman,Eric S. Lander,Joel N. Hirschhorn,Joel N. Hirschhorn,Joel N. Hirschhorn,David Altshuler,Leif Groop +24 more
TL;DR: An analytical strategy is introduced, Gene Set Enrichment Analysis, designed to detect modest but coordinate changes in the expression of groups of functionally related genes, which identifies a set of genes involved in oxidative phosphorylation whose expression is coordinately decreased in human diabetic muscle.
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Reactive oxygen species have a causal role in multiple forms of insulin resistance.
TL;DR: A genomic analysis of two cellular models of insulin resistance, one induced by treatment with the cytokine tumour-necrosis factor-α and the other with the glucocorticoid dexamethasone, suggests that reactive oxygen species levels are increased in both models, and increased ROS levels are an important trigger for insulin resistance in numerous settings.
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The adipokine lipocalin 2 is regulated by obesity and promotes insulin resistance
Qing-Wu Yan,Qin Yang,Nimesh Mody,Timothy E. Graham,Chung-Hsin Hsu,Zhao Xu,Nicholas E. Houstis,Barbara B. Kahn,Evan D. Rosen +8 more
TL;DR: Lcn2 is an adipokine with potential importance in insulin resistance associated with obesity, and forced reduction of Lcn2 in 3T3-L1 adipocytes improves insulin action.
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Mechanisms of Exercise Intolerance in Heart Failure with Preserved Ejection Fraction: The Role of Abnormal Peripheral Oxygen Extraction
Bishnu P. Dhakal,Rajeev Malhotra,Ryan M. Murphy,Paul P. Pappagianopoulos,Aaron L. Baggish,Rory B. Weiner,Nicholas E. Houstis,Aaron S. Eisman,Stacyann S. Hough,Gregory D. Lewis +9 more
TL;DR: In this article, the authors found that abnormally low peripheral o2 extraction (arterio-mixed venous o2 content difference, [C(a-v)o2]) during exercise significantly contributes to impaired exercise capacity in heart failure patients.
Journal ArticleDOI
Cardiac macrophages promote diastolic dysfunction.
Maarten Hulsmans,Hendrik B. Sager,Jason D. Roh,María Valero-Muñoz,Nicholas E. Houstis,Yoshiko Iwamoto,Yuan Sun,Richard M. Wilson,Gregory R. Wojtkiewicz,Benoit Tricot,Michael T. Osborne,Judy Hung,Claudio Vinegoni,Kamila Naxerova,Kamila Naxerova,David E. Sosnovik,Michael R. Zile,Amy D. Bradshaw,Ronglih Liao,Ahmed Tawakol,Ralph Weissleder,Anthony Rosenzweig,Filip K. Swirski,Flora Sam,Matthias Nahrendorf +24 more
TL;DR: It is shown that cardiac macrophages expand in humans and mice with diastolic dysfunction, which in mice was induced by either hypertension or advanced age, implying expansion and phenotypic changes of cardiacmacrophages as therapeutic targets for cardiac fibrosis leading to diastolics dysfunction.