Author
Nicholas J. Beeching
Other affiliations: University of Oxford, Royal Liverpool University Hospital, University of Oslo ...read more
Bio: Nicholas J. Beeching is an academic researcher from Liverpool School of Tropical Medicine. The author has contributed to research in topics: Population & Hepatitis B. The author has an hindex of 47, co-authored 316 publications receiving 8127 citations. Previous affiliations of Nicholas J. Beeching include University of Oxford & Royal Liverpool University Hospital.
Topics: Population, Hepatitis B, Cryptosporidium, Meningitis, Viral meningitis
Papers published on a yearly basis
Papers
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01 May 2022
TL;DR: The longitudinal clinical course of monkeypox in a high-income setting, coupled with viral dynamics, and any adverse events related to novel antiviral therapies are described, to highlight the urgent need for prospective studies of antivirals for this disease.
590 citations
TL;DR: A group of clinicians met in Liverpool in February 2008 to begin the development process for clinical care guidelines based around a similar simple algorithm, supported by an evidence base, whose implementation is hoped would improve the management of patients with suspected encephalitis.
312 citations
TL;DR: Management of malaria depends on awareness of the diagnosis and on performing the correct diagnostic tests, and the treatment of choice for severe or complicated malaria is currently an infusion of intravenous quinine, which is more effective in treating severe malaria in selected situations.
296 citations
TL;DR: Risk factors for Cryptosporidiosis in United Kingdom.
Abstract: We report a case-control study of sporadic cryptosporidiosis with genotyping of isolates from case-patients. A postal questionnaire was completed by 427 patients and 427 controls. We obtained genotyping data on isolates from 191 patients; 115 were Cryptosporidium hominis, and 76 were C. parvum. When all cryptosporidiosis cases were analyzed, three variables were strongly associated with illness: travel outside the United Kingdom, contact with another person with diarrhea, and touching cattle. Eating ice cream and eating raw vegetables were both strongly negatively associated with illness. Helping a child <5 years of age to use the toilet and the number of glasses of tap water drunk at home each day were also independently positively associated with risk. Eating tomatoes was negatively associated. For C. hominis infections, the strongly significant risk factors were travel abroad and changing diapers of children <5 years of age. For C. parvum, eating raw vegetables and eating tomatoes were strongly negatively associated with illness; touching farm animals was associated with illness.
225 citations
TL;DR: Sustained emphasis on improvement of vaccination coverage, birth hygiene, and surveillance, with specific approaches in high-risk areas, has meant that the incidence of the disease continues to fall.
207 citations
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Journal Article•
TL;DR: It is suggested that the natural selection against large insertion/deletion is so weak that a large amount of variation is maintained in a population.
11,521 citations
TL;DR: These predictions, based on a larger number of studies than previous estimates, indicate a growing burden of diabetes, particularly in developing countries.
6,868 citations
TL;DR: Cardiothoracic anesthetic, Southampton General Hospital, Southampton, UK Anesthesia and Intensive Care Medicine, Royal United Hospital, Bath, UK Anaesthesia and intensive care medicine, Southmead Hospital, Bristol, UK Surgical ICU, Oslo University Hospital Ulleval, Oslo, Norway Department of Cardiology, Academic Medical Center, Amsterdam, The Netherlands Critical Care and Resuscitation, University of Warwick, Warwick Medical School, Warwick, UK
2,561 citations
Erasmus University Rotterdam1, University of Pennsylvania2, Bethel University3, McMaster Children's Hospital4, National Institutes of Health5, Children's Hospital at Westmead6, University of California, San Francisco7, Kaiser Permanente Oakland Medical Center8, Claude Bernard University Lyon 19, Medical University of Vienna10, Kitasato University11, John Radcliffe Hospital12, Charité13, Cleveland Clinic14, Innsbruck Medical University15, Witten/Herdecke University16, Johns Hopkins University School of Medicine17, Catalan Institution for Research and Advanced Studies18
TL;DR: Through logical differential diagnosis, levels of evidence for autoimmune encephalitis (possible, probable, or definite) are achieved, which can lead to prompt immunotherapy.
Abstract: Summary Encephalitis is a severe inflammatory disorder of the brain with many possible causes and a complex differential diagnosis. Advances in autoimmune encephalitis research in the past 10 years have led to the identification of new syndromes and biomarkers that have transformed the diagnostic approach to these disorders. However, existing criteria for autoimmune encephalitis are too reliant on antibody testing and response to immunotherapy, which might delay the diagnosis. We reviewed the literature and gathered the experience of a team of experts with the aims of developing a practical, syndrome-based diagnostic approach to autoimmune encephalitis and providing guidelines to navigate through the differential diagnosis. Because autoantibody test results and response to therapy are not available at disease onset, we based the initial diagnostic approach on neurological assessment and conventional tests that are accessible to most clinicians. Through logical differential diagnosis, levels of evidence for autoimmune encephalitis (possible, probable, or definite) are achieved, which can lead to prompt immunotherapy.
2,391 citations
TL;DR: Concerns about the sustainability of periodic deworming with benzimidazole anthelmintics and the emergence of resistance have prompted efforts to develop and test new control tools.
2,195 citations