N
Nicola Halliwell
Researcher at University of Manchester
Publications - 10
Citations - 4408
Nicola Halliwell is an academic researcher from University of Manchester. The author has contributed to research in topics: Frontotemporal lobar degeneration & C9orf72. The author has an hindex of 7, co-authored 10 publications receiving 3864 citations.
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Journal ArticleDOI
A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD
Alan E. Renton,Elisa Majounie,Adrian James Waite,Javier Simón-Sánchez,Javier Simón-Sánchez,Sara Rollinson,J. Raphael Gibbs,J. Raphael Gibbs,Jennifer C. Schymick,Hannu Laaksovirta,John C. van Swieten,John C. van Swieten,Liisa Myllykangas,Hannu Kalimo,Anders Paetau,Yevgeniya Abramzon,Anne M. Remes,Alice Kaganovich,Sonja W. Scholz,Sonja W. Scholz,Sonja W. Scholz,Jamie Duckworth,Jinhui Ding,Daniel W. Harmer,Dena G. Hernandez,Dena G. Hernandez,Janel O. Johnson,Janel O. Johnson,Kin Y. Mok,Mina Ryten,Danyah Trabzuni,Rita Guerreiro,Richard W. Orrell,James Neal,Alexandra Murray,J. P. Pearson,Iris E. Jansen,David Sondervan,Harro Seelaar,Derek J. Blake,Kate Young,Nicola Halliwell,Janis Bennion Callister,Greg Toulson,Anna Richardson,Alexander Gerhard,Julie S. Snowden,David M. A. Mann,David Neary,Mike A. Nalls,Terhi Peuralinna,Lilja Jansson,Veli-Matti Isoviita,Anna-Lotta Kaivorinne,Maarit Hölttä-Vuori,Elina Ikonen,Raimo Sulkava,Michael Benatar,Joanne Wuu,Adriano Chiò,Gabriella Restagno,Giuseppe Borghero,Mario Sabatelli,David Heckerman,Ekaterina Rogaeva,Lorne Zinman,Jeffrey D. Rothstein,Michael Sendtner,Carsten Drepper,Evan E. Eichler,Can Alkan,Ziedulla Abdullaev,Svetlana Pack,Amalia Dutra,Evgenia Pak,John Hardy,Andrew B. Singleton,Nigel Williams,Peter Heutink,Stuart Pickering-Brown,Huw R. Morris,Huw R. Morris,Huw R. Morris,Pentti J. Tienari,Bryan J. Traynor,Bryan J. Traynor +85 more
TL;DR: The chromosome 9p21 amyotrophic lateral sclerosis-frontotemporal dementia (ALS-FTD) locus contains one of the last major unidentified autosomal-dominant genes underlying these common neurodegenerative diseases, and a large hexanucleotide repeat expansion in the first intron of C9ORF72 is shown.
Journal ArticleDOI
A Multicenter Study of Glucocerebrosidase Mutations in Dementia With Lewy Bodies
Mike A. Nalls,Raquel Duran,Grisel Lopez,Marzena Kurzawa-Akanbi,Ian G. McKeith,Patrick F. Chinnery,Christopher Morris,Jessie Theuns,Jessie Theuns,David Crosiers,David Crosiers,Patrick Cras,Sebastiaan Engelborghs,Peter Paul De Deyn,Christine Van Broeckhoven,Christine Van Broeckhoven,David M. A. Mann,Julie S. Snowden,Stuart Pickering-Brown,Nicola Halliwell,Yvonne S Davidson,Linda Gibbons,Jenny Harris,Una-Marie Sheerin,Jose Bras,John Hardy,Lorraine N. Clark,Karen Marder,Lawrence S. Honig,Daniela Berg,Walter Maetzler,Kathrin Brockmann,Thomas Gasser,Fabiana Novellino,Aldo Quattrone,Grazia Annesi,Elvira Valeria De Marco,Ekaterina Rogaeva,Mario Masellis,Mario Masellis,Sandra E. Black,Sandra E. Black,Juan M. Bilbao,Tatiana Foroud,Bernardino Ghetti,William C. Nichols,Nathan Pankratz,Glenda M. Halliday,Suzanne Lesage,Suzanne Lesage,Suzanne Lesage,Stephan Klebe,Alexandra Durr,Charles Duyckaerts,Charles Duyckaerts,Charles Duyckaerts,Alexis Brice,Benoit I. Giasson,John Q. Trojanowski,Howard I. Hurtig,Nahid Tayebi,Claudia Landazabal,Claudia Landazabal,Melanie A. Knight,Margaux F. Keller,Margaux F. Keller,Andrew B. Singleton,Tyra G. Wolfsberg,Ellen Sidransky +68 more
TL;DR: In this paper, the authors found a significant association between GBA1 mutation carrier status and DLB, with an odds ratio of 8.28 (95% CI, 4.78-14.88).
Journal ArticleDOI
The most common type of FTLD-FUS (aFTLD-U) is associated with a distinct clinical form of frontotemporal dementia but is not related to mutations in the FUS gene
Julie S. Snowden,Quan Hu,Quan Hu,Sara Rollinson,Nicola Halliwell,Andrew C Robinson,Yvonne S Davidson,Parastoo Momeni,Atik Baborie,Timothy D. Griffiths,Evelyn Jaros,Evelyn Jaros,Robert H. Perry,Anna Richardson,Anna Richardson,Stuart Pickering-Brown,David Neary,David Neary,David M. A. Mann,David M. A. Mann +19 more
TL;DR: It is concluded that aFTLD-U is associated with a distinct clinical form of frontotemporal dementia, potentially allowing identification of such patients in life with a high degree of precision and whether mutations in the FUS gene cause some cases of FTLD remains unresolved.
Journal ArticleDOI
Frontotemporal lobar degeneration genome wide association study replication confirms a risk locus shared with amyotrophic lateral sclerosis
Sara Rollinson,Simon Mead,Julie S. Snowden,Anna Richardson,Jonathan D. Rohrer,Nicola Halliwell,Suzanne Usher,David Neary,David M. A. Mann,John Hardy,Stuart Pickering-Brown +10 more
TL;DR: Analysis of the chromosome 9 locus revealed strong association in the London FTLD cohort and the Manchester FTLD+ALS cases, and confirmed that FTLD and amyotrophic lateral sclerosis (ALS) share a common genetic risk factor on chromosome 9p.
Journal ArticleDOI
Analysis of the hexanucleotide repeat in C9ORF72 in Alzheimer's disease.
Sara Rollinson,Nicola Halliwell,Kate Young,Janis Bennion Callister,Greg Toulson,Linda Gibbons,Yvonne S Davidson,Andrew C Robinson,Alexander Gerhard,Anna Richardson,David Neary,Julie S. Snowden,David M. A. Mann,Stuart Pickering-Brown +13 more
TL;DR: This work genotyped the hexanucleotide repeat region of C9ORF72 in a large cohort of patients with Alzheimer's disease (AD) and concluded that the Hexan nucleotide repeat expansion is specific to the FTLD/ALS disease spectrum.