N
Nicola J. Hawkes
Researcher at Liverpool School of Tropical Medicine
Publications - 15
Citations - 2570
Nicola J. Hawkes is an academic researcher from Liverpool School of Tropical Medicine. The author has contributed to research in topics: Gene & Anopheles gambiae. The author has an hindex of 13, co-authored 14 publications receiving 2369 citations. Previous affiliations of Nicola J. Hawkes include Vector Group Ltd. & Cardiff University.
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Journal ArticleDOI
The molecular basis of insecticide resistance in mosquitoes.
TL;DR: This paper reviews what is currently known about insecticide resistance conferred by metabolic or target site changes in mosquitoes.
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Pyrethroid and DDT cross-resistance in Aedes aegypti is correlated with novel mutations in the voltage-gated sodium channel gene.
Cécile Brengues,Nicola J. Hawkes,Fabrice Chandre,L. McCarroll,Stéphane Duchon,Pierre Guillet,Sylvie Manguin,John C. Morgan,Janet Hemingway +8 more
TL;DR: Four novel mutations were identified in dengue vector mosquito Aedes aegypti (L.) and direct neurophysiological assays on individual larvae from three strains demonstrated reduced nerve sensitivity to permethrin or lambda cyhalothrin inhibition compared to the susceptible strains.
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Genomic analysis of detoxification genes in the mosquito Aedes aegypti
Clare Strode,Charles S. Wondji,Jean-Philippe David,Nicola J. Hawkes,Nongkran Lumjuan,David R. Nelson,David R. Drane,S. H. P. Parakrama Karunaratne,Janet Hemingway,William C. Black,Hilary Ranson +10 more
TL;DR: Annotation of the recently determined genome sequence of the major dengue vector, Aedes aegypti, reveals an abundance of detoxification genes, and an array containing unique oligonucleotide probes for these genes was constructed and compared their expression level in insecticide resistant and susceptible strains.
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Can multiple‐copy sequences of prey DNA be detected amongst the gut contents of invertebrate predators?
TL;DR: Having demonstrated that shorter, multiple‐copy sequences survive digestion for a considerable period in the gut of a predator, the opportunity exists to develop new detection systems for studying predation in the field.
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Resistance-associated point mutations of organophosphate insensitive acetylcholinesterase, in the olive fruit fly Bactrocera oleae
TL;DR: This is the first agricultural pest where resistance has been associated with an alteration in AChE, which arises from point mutations located within the active site gorge of the enzyme.