How has Japan become a major economic power, a world leader in the automotive and electronics industries? What is the secret of their success? The consensus has been that, though the Japanese are not particularly innovative, they are exceptionally skilful at imitation, at improving products that already exist. But now two leading Japanese business experts, Ikujiro Nonaka and Hiro Takeuchi, turn this conventional wisdom on its head: Japanese firms are successful, they contend, precisely because they are innovative, because they create new knowledge and use it to produce successful products and technologies. Examining case studies drawn from such firms as Honda, Canon, Matsushita, NEC, 3M, GE, and the U.S. Marines, this book reveals how Japanese companies translate tacit to explicit knowledge and use it to produce new processes, products, and services.

The knowledge-creating company : how Japanese companies create the dynamics of innovation

ing WS1S Systems to Verify Parameterized Networks . . . . . . . . . . . . 188 Kai Baukus, Saddek Bensalem, Yassine Lakhnech and Karsten Stahl FMona: A Tool for Expressing Validation Techniques over Infinite State Systems . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 204 J.-P. Bodeveix and M. Filali Transitive Closures of Regular Relations for Verifying Infinite-State Systems . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 220 Bengt Jonsson and Marcus Nilsson Diagnostic and Test Generation Using Static Analysis to Improve Automatic Test Generation . . . . . . . . . . . . . 235 Marius Bozga, Jean-Claude Fernandez and Lucian Ghirvu Efficient Diagnostic Generation for Boolean Equation Systems . . . . . . . . . . . . 251 Radu Mateescu Efficient Model-Checking Compositional State Space Generation with Partial Order Reductions for Asynchronous Communicating Systems . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 266 Jean-Pierre Krimm and Laurent Mounier Checking for CFFD-Preorder with Tester Processes . . . . . . . . . . . . . . . . . . . . . . . 283 Juhana Helovuo and Antti Valmari Fair Bisimulation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 299 Thomas A. Henzinger and Sriram K. Rajamani Integrating Low Level Symmetries into Reachability Analysis . . . . . . . . . . . . . 315 Karsten Schmidt Model-Checking Tools Model Checking Support for the ASM High-Level Language . . . . . . . . . . . . . . 331 Giuseppe Del Castillo and Kirsten Winter Table of

Tools and Algorithms for the Construction and Analysis of Systems. Proc. TACAS 2009

The Martini coarse-grained force field has been successfully used for simulating a wide range of (bio)molecular systems. Recent progress in our ability to test the model against fully atomistic force fields, however, has revealed some shortcomings. Most notable, phenylalanine and proline were too hydrophobic, and dimers formed by polar residues in apolar solvents did not bind strongly enough. Here, we reparametrize these residues either through reassignment of particle types or by introducing embedded charges. The new parameters are tested with respect to partitioning across a lipid bilayer, membrane binding of Wimley–White peptides, and dimerization free energy in solvents of different polarity. In addition, we improve some of the bonded terms in the Martini protein force field that lead to a more realistic length of α-helices and to improved numerical stability for polyalanine and glycine repeats. The new parameter set is denoted Martini version 2.2.

/pdf/improved-parameters-for-the-martini-coarse-grained-protein-4ecsxredvf.pdf

Improved Parameters for the Martini Coarse-Grained Protein Force Field

The Martini model, a coarse-grained force field for biomolecular simulations, has found a broad range of applications since its release a decade ago. Based on a building block principle, the model combines speed and versatility while maintaining chemical specificity. Here we review the current state of the model. We describe recent highlights as well as shortcomings, and our ideas on the further development of the model.

/pdf/perspective-on-the-martini-model-48a9823w5f.pdf

Perspective on the Martini model.

For simulations of membranes and membrane proteins, the generation of the lipid bilayer is a critical step in the setup of the system. Membranes comprising multiple components pose a particular challenge, because the relative abundances need to be controlled and the equilibration of the system may take several microseconds. Here we present a comprehensive method for building membrane containing systems, characterized by simplicity and versatility. The program uses preset, coarse-grain lipid templates to build the membrane, and also allows on-the-fly generation of simple lipid types by specifying the headgroup, linker, and lipid tails on the command line. The resulting models can be equilibrated, after which a relaxed atomistic model can be obtained by reverse transformation. For multicomponent membranes, this provides an efficient means for generating equilibrated atomistic models. The method is called insane, an acronym for INSert membrANE. The program has been made available, together with the complemen...

Computational Lipidomics with insane: A Versatile Tool for Generating Custom Membranes for Molecular Simulations

When it is tried to control drones, there are many different ways through various devices, using either motions like facial motion, special gloves with sensors, red, green, blue cameras on the laptop or even using smartwatches by performing gestures that are picked up by motion sensors. The paper proposes a work on how drones could be controlled using brainwaves without any of those devices. The drone control system of the current research was developed using electroencephalogram signals took by an Emotiv Insight headset. The electroencephalogram signals are collected from the user’s brain. The processed signal is then sent to the computer via Bluetooth. The headset employs Bluetooth Low Energy for wireless transmission. The brain of the user is trained in order to use the generated electroencephalogram data. The final signal is transmitted to Raspberry Pi zero via the MQTT messaging protocol. The Raspberry Pi controls the movement of the drone through the incoming signal from the headset. After years, brain control can replace many normal input sources like keyboards, touch screens or other traditional ways, so it enhances interactive experiences and provides new ways for disabled people to engage with their surroundings.

Drone Control based on Mental Commands and Facial Expressions

The simulations done in molecular dynamics (MD) are used to learn about the behavior of macromolecular systems. While analyzing large macromolecular systems, the computation can last long, many times for days, weeks and months, due to which the need of parallelization occurs for shortening the time. The graphics processing unit (GPU) yields to multithread computational capacity by the use of CUDA high-level language which suits the molecular dynamics algorithms. The OpenCL platform allows its reckoning kernels to run without difficulty on GPUs, as well as on multicore computers. We developed a new thermostat that combines Langevin dynamics with the global Berendsen thermostat which is parallelized in CUDA, as well as in OpenCL. The GPU parallelization is presented in this paper by applying stochastic dynamics, respectively the Langevin integrator, together with the Berendsen thermostat. A system of atoms is tested by taking into consideration the friction coefficient and the coupling parameter.

http://www.computer.org/csdl/proceedings/icccnt/2015/7984/00/07395220.pdf

Improved OpenMM algorithms for CUDA and OpenCL using new stochastic dynamics and the Berendsen thermostat

Engineering of medical informatics systems is a complex work because it is at the intersection of several critical domains, among which medicine, computer science, electrical engineering to mention just a few. One critical aspect of such systems is the interoperability of the different components. One key solution for the interoperability is the creation of good standards that will assure the interchange of data between products of several vendors and domains - medical devices, medical information systems, medical data, etc. In this paper a formal analysis of the ISO/IEEE 11073 −20601: 2016 Draft Standard for Health informatics - Personal health device communication - Application profile - Optimized exchange protocol is described. This family of standards specifies the communication between devices that can be agents (weighing scales, spirometers) which measure health related data and managers (laptop, smartphone etc.) that collect the information and can display or forward it. First the protocol was modeled in Promela and then the model was checked manually and also using the Spin tool that performed an automated check. The results revealed issues which can cause deadlocks. However, these issues appeared in exceptional workflows, the normal flow being designed well. This highlights the methodology of developing such protocols: concentration on normal, intended behaviors without dealing with exceptional behaviors. Using formal models can reveal problems with exceptional behaviors. The results and proposed solutions were reported to the IEEE 1073 working group and will be integrated in the standard.

/pdf/model-checking-the-properties-of-iso-ieee-11073-20601-2016-3dzv3rmrpr.pdf

Model checking the properties of ISO/IEEE 11073-20601:2016 standard-based communication protocol for personal health device

Digital instruments play a vital role in our daily life. It is a routine to produce business papers, watch the news program, write articles and blogs, manage healthcare systems, to purchase online, to send messages and all this is processed by making observations and then manipulating, receiving and availing the diverse data. This electronic data provides the foundation of real time data. All this transmission of data needs to be secured. Security is essential for healthcare systems as the present one where the blood pressure recordings provided by the smart bracelet are sent to the user’s mobile phone via Bluetooth. The bracelet monitors the pregnant women, but also other users who wish to have their blood pressure under control. The system’s server analyses the recordings and announces the user, as well as the associated persons to the user in case of an emergency. The doctors, the medical staff, user and user’s family and caregivers have access to the health recordings belonging to the monitored user. Security is a main feature of the electronic healthcare system based on the smart bracelet.

/pdf/securing-the-network-for-a-smart-bracelet-system-3ho69n3kil.pdf

Securing the Network for a Smart Bracelet System

The algorithm described in this paper is part of a program supporting the process of teeth contour detection, segmentation and 3D reconstruction. The data is taken from dental conical tomographies. Automatic contour detection starts by filtering the image according to an adaptive threshold. The region of interest is established and the tooth contour is determined using the possible edge directions. The applied method is innovative for the contour detection, because it exploits the domain knowledge, where each tooth (incisor, canine, premolar, molar) has a certain shape. For touching teeth, the delimitation is automatically performed by drawing a line using the Bresenham algorithm. The algorithm will further contribute to the determination and treatment of teeth pathologies.

Nicolae Goga

Papers

Drone Control based on Mental Commands and Facial Expressions

Improved OpenMM algorithms for CUDA and OpenCL using new stochastic dynamics and the Berendsen thermostat

Model checking the properties of ISO/IEEE 11073-20601:2016 standard-based communication protocol for personal health device

Securing the Network for a Smart Bracelet System

Automatic contour detection from dental CBCT DICOM data