http://chemotaxis.semmelweis.hu/CHTXhpg/Durotaxis/LoCM_BiophysJ_2000.pdf

Cell Movement Is Guided by the Rigidity of the Substrate

An overview is presented of the current state-of-the-art in silicon nanophotonic ring resonators. Basic theory of ring resonators is discussed, and applied to the peculiarities of submicron silicon photonic wire waveguides: the small dimensions and tight bend radii, sensitivity to perturbations and the boundary conditions of the fabrication processes. Theory is compared to quantitative measurements. Finally, several of the more promising applications of silicon ring resonators are discussed: filters and optical delay lines, label-free biosensors, and active rings for efficient modulators and even light sources.

/pdf/silicon-microring-resonators-3fzr4lpxbh.pdf

Silicon microring resonators

Broadband and low loss capability of photonics has led to an ever-increasing interest in its use for the generation, processing, control and distribution of microwave and millimeter-wave signals for applications such as broadband wireless access networks, sensor networks, radar, satellite communitarians, instrumentation and warfare systems. In this tutorial, techniques developed in the last few years in microwave photonics are reviewed with an emphasis on the systems architectures for photonic generation and processing of microwave signals, photonic true-time delay beamforming, radio-over-fiber systems, and photonic analog-to-digital conversion. Challenges in system implementation for practical applications and new areas of research in microwave photonics are also discussed.

Microwave Photonics

The human corneal basement membrane has a rich felt-like surface topography with feature dimensions between 20 nm and 200 nm. On the basis of these findings, we designed lithographically defined substrates to investigate whether nanotopography is a relevant stimulus for human corneal epithelial cells. We found that cells elongated and aligned along patterns of grooves and ridges with feature dimensions as small as 70 nm, whereas on smooth substrates, cells were mostly round. The percentage of aligned cells was constant on substrate tomographies with lateral dimensions ranging from the nano- to the micronscale, and increased with groove depth. The presence of serum in the culture medium resulted in a larger percentage of cells aligning along the topographic patterns than when no serum was added to the basal medium. When present, actin microfilaments and focal adhesions were aligned along the substrate topographies. The width of the focal adhesions was determined by the width of the ridges in the underlying substrate. This work documents that biologic length-scale topographic features that model features encountered in the native basement membrane can profoundly affect epithelial cell behavior.

/pdf/epithelial-contact-guidance-on-well-defined-micro-and-2a54rblps5.pdf

Epithelial contact guidance on well-defined micro- and nanostructured substrates

http://www.tissueeng.net/lab/papers/124.pdf

Engineering microscale topographies to control the cell-substrate interface.

We design and demonstrate broadband directional couplers that use asymmetric-waveguide based phase control sections, on the silicon-on-insulator platform. Broadband directional couplers with various power splitting ratios, including 10%/90%, 20%/80%, 30%/70%, 40%/60% and 50%/50%, were realized for both transverse electric (TE) and transverse magnetic (TM) modes. Some of the devices exhitbit bandwidths in excess of 100 nm, and all in excess of 75 nm. The footprints of the TE mode couplers are 32 μm ×1.3 μm, or less, and those of the TM mode couplers are 13 μm ×1.3 μm, or less.

Broadband silicon photonic directional coupler using asymmetric-waveguide based phase control.

We demonstrate the design, fabrication and measurement of integrated Bragg gratings in a compact single-mode silicon-on-insulator ridge waveguide. The gratings are realized by corrugating the sidewalls of the waveguide, either on the ridge or on the slab. The coupling coefficient is varied by changing the corrugation width which allows precise control of the bandwidth and has a high fabrication tolerance. The grating devices are fabricated using a CMOS-compatible process with 193 nm deep ultraviolet lithography. Spectral measurements show bandwidths as narrow as 0.4 nm, which are promising for on-chip applications that require narrow bandwidths such as WDM channel filters. We also present the die-to-die nonuniformity for the grating devices on the wafer, and our analysis shows that the Bragg wavelength deviation is mainly caused by the wafer thickness variation.

Narrow-band waveguide Bragg gratings on SOI wafers with CMOS-compatible fabrication process.

We demonstrate fully-etched fiber-waveguide grating couplers with sub-wavelength gratings showing high coupling efficiency as well as low back reflections for both transverse electric (TE) and transverse magnetic (TM) modes. The power reflection coefficients for the TE and TM modes have been significantly suppressed to -16.2 dB and -20.8 dB, respectively. Focusing grating lines have also been used to reduce the footprint of the design. Our sub-wavelength grating couplers for the TE and TM modes show respective measured insertion losses of 4.1 dB and 3.7 dB with 1-dB bandwidths of 30.6 nm (3-dB bandwidth of 52.3 nm) and 47.5 nm (3-dB bandwidth of 81.5 nm), respectively.

Focusing sub-wavelength grating couplers with low back reflections for rapid prototyping of silicon photonic circuits

A novel ultrahigh-speed electro-optic polarization modulator is introduced. The modulator uses a mode converter and a static polarization controller to change the output polarization state in a circular path, following a great circle, around the Poincare sphere. Any two states on the Poincare sphere can be connected. The mode converter is constructed using an AlGaAs ridge waveguide combined with slow-wave travelling wave electrodes. The travelling wave electrodes are designed to match the velocity of the electrical modulating signal, the data signal, to the optical carrier signal over a broad frequency range. This modulator demonstrates a 3 dB bandwidth in excess of 40 GHz. The polarization modulator exhibits extremely low differential group delay, on the order of a few 10s of femto-seconds, and low drive voltage, on the order of 5 V.

/pdf/40-ghz-electro-optic-polarization-modulator-for-fiber-optic-1496dl1fi2.pdf

40 GHz electro-optic polarization modulator for fiber optic communications systems

We demonstrate, in both theory and experiment, 4-port, electrically tunable photonic filters using silicon contra-directional couplers (contra-DCs) with uniform and phase-shifted waveguide Bragg gratings. Numerical analysis, including both intra- and inter-waveguide couplings, is performed using coupled-mode theory and the transfer-matrix method. The contra-DC devices were fabricated by a CMOS-photonics manufacturing foundry and are electrically tunable using free-carrier injection. A 4-port, grating-based photonic resonator has been obtained using the phase-shifted contra-DC, showing a resonant peak with a 3-dB bandwidth of 0.2 nm and an extinction ratio of 24 dB. These contra-DC devices enable on-chip integration of Bragg-grating-defined functions without using circulators and have great potential for applications such as wavelength-division multiplexing networks and optical signal processing.

Nicolas A. F. Jaeger

Papers

Broadband silicon photonic directional coupler using asymmetric-waveguide based phase control.

Narrow-band waveguide Bragg gratings on SOI wafers with CMOS-compatible fabrication process.

Focusing sub-wavelength grating couplers with low back reflections for rapid prototyping of silicon photonic circuits

40 GHz electro-optic polarization modulator for fiber optic communications systems

Silicon photonic grating-assisted, contra-directional couplers