N
Nicolas F. Schlecht
Researcher at Albert Einstein College of Medicine
Publications - 112
Citations - 6071
Nicolas F. Schlecht is an academic researcher from Albert Einstein College of Medicine. The author has contributed to research in topics: Head and neck squamous-cell carcinoma & Cancer. The author has an hindex of 35, co-authored 101 publications receiving 5478 citations. Previous affiliations of Nicolas F. Schlecht include Yeshiva University & Roswell Park Cancer Institute.
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Journal ArticleDOI
Persistent human papillomavirus infection as a predictor of cervical intraepithelial neoplasia.
Nicolas F. Schlecht,Sophie Kulaga,Juliette Robitaille,Silvaneide Ferreira,Monica Santos,Romulo A. Miyamura,Eliane Duarte-Franco,Thomas E. Rohan,Alex Ferenczy,Luisa L. Villa,Eduardo L. Franco +10 more
TL;DR: A strong relationship exists between persistent HPV infections and SIL incidence, particularly for HPV types 16 and 18, which is believed to be the central cause of cervical cancer.
Journal ArticleDOI
Natural History and Possible Reactivation of Human Papillomavirus in Human Immunodeficiency Virus–Positive Women
Howard D. Strickler,Robert D. Burk,Melissa Fazzari,Kathryn Anastos,Howard Minkoff,L. Stewart Massad,Charles B. Hall,Melanie C. Bacon,Alexandra M. Levine,D. Heather Watts,Michael J. Silverberg,Xiaonan Xue,Nicolas F. Schlecht,Sandra Melnick,Joel M. Palefsky +14 more
TL;DR: In HIV-positive women, plasma HIV RNA level and CD4+ count in combination appear to have a strong and statistically interactive association with incident detection of HPV, some of which may reflect HPV reactivation (e.g., in sexually inactive women).
Journal ArticleDOI
Low-Level Expression of MicroRNAs let-7d and miR-205 Are Prognostic Markers of Head and Neck Squamous Cell Carcinoma
Geoffrey Childs,Melissa Fazzari,Gloria Kung,Nicole Kawachi,Margaret Brandwein-Gensler,Michael Steven McLemore,Quan Chen,Robert D. Burk,Richard V. Smith,Michael B. Prystowsky,Thomas J. Belbin,Nicolas F. Schlecht +11 more
TL;DR: It is shown that miRNA expression levels can be used as prognostic markers of head and neck cancer and low levels of hsa-miR205 are significantly associated with loco-regional recurrence independent of disease severity at diagnosis and treatment.
Journal ArticleDOI
Human Papillomavirus Infection and Time to Progression and Regression of Cervical Intraepithelial Neoplasia
Nicolas F. Schlecht,Robert W. Platt,Eliane Duarte-Franco,Maria Cecília Costa,João P. Sobrinho,José C. M. Prado,Alex Ferenczy,Thomas E. Rohan,Luisa L. Villa,Eduardo L. Franco +9 more
TL;DR: Preursor lesions of the cervix persist longer and progress more quickly in women with oncogenic HPV infections than in womenwith non-oncogenic infections or without HPV, which may help identify those that are likely to progress rapidly.
Journal ArticleDOI
The epidemiology of cervical cancer.
TL;DR: The available evidence indicates that the HPV-cervical cancer association satisfies all relevant causal criteria for public health action and is the first instance in which a necessary cause has been demonstrated in cancer epidemiology--a realization that has obvious implications for primary and secondary prevention of this neoplastic disease.