N
Nicolas Heinemann
Researcher at Humboldt University of Berlin
Publications - 5
Citations - 267
Nicolas Heinemann is an academic researcher from Humboldt University of Berlin. The author has contributed to research in topics: Viral replication & Autophagy. The author has an hindex of 2, co-authored 3 publications receiving 119 citations. Previous affiliations of Nicolas Heinemann include Charité.
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Journal ArticleDOI
SARS-CoV-2-mediated dysregulation of metabolism and autophagy uncovers host-targeting antivirals.
Nils C. Gassen,Jan Papies,Jan Papies,Thomas Bajaj,Jackson Emanuel,Jackson Emanuel,Frederik Dethloff,Robert Lorenz Chua,Jakob Trimpert,Nicolas Heinemann,Nicolas Heinemann,Christine Niemeyer,Friderike Weege,Friderike Weege,Katja Hönzke,Tom Aschman,Daniel E. Heinz,Katja Weckmann,Tim Ebert,Andreas Zellner,M. Lennarz,Emanuel Wyler,Simon Schroeder,Simon Schroeder,Anja Richter,Anja Richter,Daniela Niemeyer,Daniela Niemeyer,Karen Hoffmann,Thomas F. Meyer,Frank L. Heppner,Frank L. Heppner,Victor M. Corman,Victor M. Corman,Markus Landthaler,Markus Landthaler,Andreas C. Hocke,Markus Morkel,Markus Morkel,Nikolaus Osterrieder,Nikolaus Osterrieder,Christian Conrad,Roland Eils,Roland Eils,Helena Radbruch,Patrick Giavalisco,Christian Drosten,Christian Drosten,Marcel A. Müller +48 more
TL;DR: In this paper, the authors show that SARS-CoV-2 infection modulates cellular metabolism and limits autophagy, and identify druggable host pathways for virus inhibition.
Posted ContentDOI
Analysis of SARS-CoV-2-controlled autophagy reveals spermidine, MK-2206, and niclosamide as putative antiviral therapeutics
Nils C. Gassen,Jan Papies,Jan Papies,Thomas Bajaj,Frederik Dethloff,Jackson Emanuel,Jackson Emanuel,Katja Weckmann,Daniel E. Heinz,Nicolas Heinemann,Nicolas Heinemann,M. Lennarz,Anja Richter,Anja Richter,Daniela Niemeyer,Daniela Niemeyer,Victor M. Corman,Victor M. Corman,Patrick Giavalisco,Christian Drosten,Christian Drosten,Marcel A. Müller,Marcel A. Müller +22 more
TL;DR: It is shown that SARS-CoV-2 infection limits autophagy by interfering with multiple metabolic pathways and that compound-driven interventions aimed at Autophagy induction reduce Sars-Cov-2 propagation in vitro.
Journal ArticleDOI
Antiviral and Immunomodulatory Effects of Pelargonium sidoides DC. Root Extract EPs® 7630 in SARS-CoV-2-Infected Human Lung Cells.
Jan Papies,Jan Papies,Jackson Emanuel,Jackson Emanuel,Nicolas Heinemann,Nicolas Heinemann,Žarko Kulić,Simon Schroeder,Simon Schroeder,Beate Tenner,Martin D Lehner,Georg Seifert,Georg Seifert,Marcel A. Müller,Marcel A. Müller +14 more
TL;DR: In this paper, Pelargonium sidoides DC. root extract EPs 7630 has antiviral and immunomodulatory properties, limiting symptom severity and disease duration of infections with several upper respiratory viruses.
Journal ArticleDOI
SARS-CoV-2 variant Alpha has a spike-dependent replication advantage over the ancestral B.1 strain in human cells with low ACE2 expression
Daniela Niemeyer,Saskia Stenzel,Talitha Veith,Simon Schroeder,Kirstin Friedmann,Friderike Weege,Jakob Trimpert,Julian Heinze,Anja Richter,Jenny Jansen,Jackson Emanuel,Julia Kazmierski,Fabian Pott,Lara Maria Jeworowski,Ruth Olmer,Mark-Christian Jaboreck,Beate Tenner,Jan Papies,F. Walper,Marie Luisa Schmidt,Nicolas Heinemann,Elisabeth Möncke-Buchner,Morris Baumgardt,Karen Hoffmann,Marek Widera,Tran Thi Nhu Thao,Anita Balázs,Jessica Schulze,C. Mache,Terry Jones,Markus Morkel,Sandra Ciesek,Leif G. Hanitsch,Marcus A. Mall,A. Hocker,V. Thiel,Klaus Osterrieder,Thorsten Wolff,Ulrich Martin,Victor M. Corman,Marcel A. Müller,Christine Goffinet,Christian Drosten +42 more
TL;DR: In this article , an extensive functional study of VOC Alpha replication and cell entry phenotypes assisted by reverse genetics, mutational mapping of spike in lentiviral pseudotypes, viral and cellular gene expression studies, and infectivity stability assays in an enhanced range of cell and epithelial culture models.
Posted ContentDOI
Pharmacological inhibition of bromodomain and extra-terminal proteins induces NRF-2-mediated inhibition of SARS-CoV-2 replication and is subject to viral antagonism
Baxolele Mhlekude,Dylan Postmus,January Weiner,Saskia Stenzel,Francisco J. Zapatero-Belinchón,Ruth Olmer,Jenny Jansen,Anja Richter,Julian Heinze,Nicolas Heinemann,Barbara Mühlemann,Simon Schroeder,Terry Jones,Marcel A. Müller,Christian Drosten,Andreas Pich,V. Thiel,Ulrich Martin,Daniela Niemeyer,Gisa Gerold,Dieter Beule,Christine Goffinet +21 more
TL;DR: It is proposed that JQ-1 exerts pleiotropic effects that collectively induce a transient antiviral state that is ultimately nullified by an established SARS-CoV-2 infection, raising questions on their clinical suitability in the context of COVID-19.