Nicolas Rapin

TL;DR: It is shown that enhancers share properties with CpG-poor messenger RNA promoters but produce bidirectional, exosome-sensitive, relatively short unspliced RNAs, the generation of which is strongly related to enhancer activity.

TL;DR: An agent-based simulator of the immune response is extended such that it represents pathogens, as well as lymphocytes receptors, by means of their amino acid sequences and makes use of bioinformatics methods for T and B cell epitope prediction, which shows that the simulator produces dynamics that are stable and consistent with basic immunological knowledge.

TL;DR: Results show that residual PRC2 activity is required for the proliferation of H3K27M-expressing DIPGs, and that inhibition of EZH2 is a potential therapeutic strategy for the treatment of these tumors.

TL;DR: The database now includes 23 high-quality curated data sets relevant to normal and malignant blood formation and, in addition, it has assembled and built a unique integrated data set, BloodPool, which contains more than 2000 samples assembled from six independent studies on acute myeloid leukemia.

TL;DR: It is proposed that TET2 prevents leukemic transformation by protecting enhancers from aberrant DNA methylation and that it is the combined silencing of several tumor suppressor genes in Tet2 mutated hematopoietic cells that contributes to increased stem cell proliferation and leukemogenesis.