Nicolas Regamey

TL;DR: The airway epithelium acts as a frontline defense against respiratory viruses, not only as a physical barrier and through the mucociliary apparatus but also through its immunological functions, which initiates multiple innate and adaptive immune mechanisms which are crucial for efficient antiviral responses.

TL;DR: STRA in children was characterized by remodeling and variable airway eosinophil counts, and despite the wide range in eosine counts, the T(H)2 mediators that are thought to drive allergic asthma were mostly absent.

TL;DR: Th17 lymphocytes are present in the airway submucosa in CF, even in a young, newly diagnosed group, and there was a significant correlation between IL-17 and neutrophil counts.

TL;DR: It is shown that compared with non-allergic healthy control children, bronchial epithelial cells cultured ex vivo from severe therapy resistant atopic asthmatic children have profoundly impaired interferon-β and interferons-λ mRNA and protein in response to rhinovirus (RV) and polyIC stimulation, and this is a feature of STRA.

TL;DR: Raised levels of inflammatory cells were frequently found in children with asthma of all severities and sputum inflammatory phenotype was not stable in childrenWith asthma, there were no differences in severity, asthma control, atopy, ICS dose or forced expiratory volume in 1 s between those who were always non-eosinophilic and those always eosinophile.