N
Nicole A. Kukutsch
Researcher at University of Erlangen-Nuremberg
Publications - 11
Citations - 4227
Nicole A. Kukutsch is an academic researcher from University of Erlangen-Nuremberg. The author has contributed to research in topics: T cell & Dendritic cell. The author has an hindex of 5, co-authored 7 publications receiving 4107 citations.
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Journal ArticleDOI
An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrow.
Manfred B. Lutz,Nicole A. Kukutsch,A. L. J. Ogilvie,Susanne Rössner,Franz Koch,Nikolaus Romani,Gerold Schuler +6 more
TL;DR: This method allows by simple means the generation of high numbers of murine DC with very low B cell or granulocyte contaminations, which will be valuable to study DC biology notably at the molecular level.
Journal ArticleDOI
Repetitive Injections of Dendritic Cells Matured with Tumor Necrosis Factor α Induce Antigen-specific Protection of Mice from Autoimmunity
Mauritius Menges,Susanne Rößner,Constanze Voigtländer,Heike Schindler,Nicole A. Kukutsch,Christian Bogdan,Klaus J. Erb,Gerold Schuler,Manfred B. Lutz +8 more
TL;DR: It is described that stimulation by TNF-α results in incompletely matured DCs (semi-mature DCs) which induce peptide-specific IL-10–producing T cells in vivo and prevent EAE.
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Immature dendritic cells generated with low doses of GM‐CSF in the absence of IL‐4 are maturation resistant and prolong allograft survival in vivo
Manfred B. Lutz,R M Suri,M Niimi,A. L. J. Ogilvie,Nicole A. Kukutsch,Susanne Rössner,Gerold Schuler,Jonathan M. Austyn +7 more
TL;DR: These maturation‐resistant immature GMlo DC induced T cell unresponsiveness in vitro and in vivo and may have important implications for future studies in T cell tolerance induction in vivo.
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Culture of bone marrow cells in GM-CSF plus high doses of lipopolysaccharide generates exclusively immature dendritic cells which induce alloantigen-specific CD4 T cell anergy in vitro.
TL;DR: These findings might contribute to the understanding of reduced T cell immunity in the course of septic shock and find application in DC‐mediated tolerogenic immunotherapy strategies.
Journal ArticleDOI
Formation and kinetics of MHC class I-ovalbumin peptide complexes on immature and mature murine dendritic cells.
TL;DR: Pulse-chase experiments revealed a constant half-life of peptide/Kb complexes independent of preceding DC stimulation or their maturation stage, which might have important implications for the clinical application of peptides-pulsed DC in tumor immunotherapy.