N
Nicole Schwarz
Researcher at University of Hamburg
Publications - 12
Citations - 1163
Nicole Schwarz is an academic researcher from University of Hamburg. The author has contributed to research in topics: NAD+ kinase & Ion channel. The author has an hindex of 10, co-authored 12 publications receiving 1038 citations.
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Journal ArticleDOI
Single domain antibodies: promising experimental and therapeutic tools in infection and immunity.
Janusz Wesolowski,Vanina Alzogaray,Jan Reyelt,Mandy Unger,Karla Juarez,Karla Juarez,Mariela Urrutia,Ana Cauerhff,Welbeck Danquah,Björn Rissiek,Felix Scheuplein,Nicole Schwarz,Sahil Adriouch,Olivier Boyer,Michel Seman,Alexei Licea,David V. Serreze,Fernando Alberto Goldbaum,Friedrich Haag,Friedrich Koch-Nolte +19 more
TL;DR: The results of several recent proof-of-principle studies are reviewed that open the exciting perspective of using sdAbs for modulating immune functions and for targeting toxins and microbes.
Journal ArticleDOI
Nanobodies that block gating of the P2X7 ion channel ameliorate inflammation.
Welbeck Danquah,Catherine Meyer-Schwesinger,Björn Rissiek,Carolina Pinto,Arnau Serracant-Prat,Miriam Amadi,Domenica Iacenda,Jan-Hendrik Knop,Anna Hammel,Philine Bergmann,Philine Bergmann,Nicole Schwarz,Joana Assuncao,Wendy Rotthier,Friedrich Haag,Eva Tolosa,Peter Bannas,Eric Boué-Grabot,Tim Magnus,Toon Laeremans,Catelijne Stortelers,Friedrich Koch-Nolte +21 more
TL;DR: The results show that nanobody technology can generate potent, specific therapeutics against ion channels, confirm P2x7 as a therapeutic target for inflammatory disorders, and characterize a potent new drug candidate that targets P2X7.
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Single domain antibodies from llama effectively and specifically block T cell ecto-ADP-ribosyltransferase ART2.2 in vivo
Friedrich Koch-Nolte,Jan Reyelt,Britta Schößow,Nicole Schwarz,Felix Scheuplein,Stefan Rothenburg,Friedrich Haag,Vanina Alzogaray,Ana Cauerhff,Fernando Alberto Goldbaum +9 more
TL;DR: A proof of principle that opens up a new avenue for targeting leukocyte ecto‐enzymes in vivo and that can serve as a model also for developing new antidotes against ADP‐ribosylating toxins is formed.
Journal ArticleDOI
ADP-ribosylation at R125 gates the P2X7 ion channel by presenting a covalent ligand to its nucleotide binding site
Sahil Adriouch,Peter Bannas,Nicole Schwarz,Ralf Fliegert,Andreas H. Guse,Michel Seman,Friedrich Haag,Friedrich Koch-Nolte +7 more
TL;DR: The results indicate that ADP‐ribosylation of R125 positions this common chemical framework to fit into the nucleotide‐binding site of P2X7 and thereby gates the channel.
Journal ArticleDOI
Differential Regulation of P2X7 Receptor Activation by Extracellular Nicotinamide Adenine Dinucleotide and Ecto-ADP-Ribosyltransferases in Murine Macrophages and T Cells
Shiyuan Hong,Nicole Schwarz,Anette Brass,Michel Seman,Friedrich Haag,Friedrich Koch-Nolte,William P. Schilling,George R. Dubyak +7 more
TL;DR: The findings indicate that extracellular NAD and ATP can act synergistically to regulate P2X7R signaling in murine macrophages and also suggest that the cellular context in which P2x7r signaling occurs differs between myeloid and lymphoid leukocytes.