N
Nicole Thomasset
Researcher at Lawrence Berkeley National Laboratory
Publications - 3
Citations - 792
Nicole Thomasset is an academic researcher from Lawrence Berkeley National Laboratory. The author has contributed to research in topics: Stromal cell & Mammary gland. The author has an hindex of 3, co-authored 3 publications receiving 763 citations. Previous affiliations of Nicole Thomasset include University of California, San Francisco.
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Journal ArticleDOI
Two distinct phases of apoptosis in mammary gland involution: proteinase-independent and -dependent pathways.
Leif R. Lund,John Romer,Nicole Thomasset,Helene Solberg,Charles Pyke,Mina J. Bissell,Keld Danø,Zena Werb +7 more
TL;DR: The data support the hypothesis that there are at least two distinct phases of involution: an initial phase, characterized by induction of the apoptosis-associated genes SGP-2 and ICE and apoptosis of fully differentiated mammary epithelial cells without visible degradation of the extracellular matrix, and a second phase, characterize by extrace cellular matrix remodeling and altered mesenchymal-epithelial interactions, followed by apoptotic cells that are losing differentiated functions.
Journal ArticleDOI
Expression of Autoactivated Stromelysin-1 in Mammary Glands of Transgenic Mice Leads to a Reactive Stroma During Early Development
Nicole Thomasset,André Lochter,Carolyn J. Sympson,Leif R. Lund,DeWight R. Williams,Ole Behrendtsen,Zena Werb,Mina J. Bissell +7 more
TL;DR: It is proposed that the highly reactive stroma provides a prelude to breast epithelial tumors observed in these animals.
Journal Article
Extracellular matrix remodeling and the regulation of epithelial-stromal interactions during differentiation and involution
Zena Werb,Carolyn J. Sympson,Caroline M. Alexander,Nicole Thomasset,Leif R. Lund,Alasdair MacAuley,John Ashkenas,Mina J. Bissell +7 more
TL;DR: It is suggested that metalloproteinases and disruption of the basement membrane may play key roles in branching morphogenesis of mammary gland, cell cycle, apoptosis, and stromal fibrosis as well as in induction and progression of breast cancer.