Author
Nigel C. Veitch
Other affiliations: University of Oxford, École Polytechnique Fédérale de Lausanne, University of Birmingham
Bio: Nigel C. Veitch is an academic researcher from Royal Botanic Gardens. The author has contributed to research in topics: Kaempferol & Peroxidase. The author has an hindex of 37, co-authored 111 publications receiving 5201 citations. Previous affiliations of Nigel C. Veitch include University of Oxford & École Polytechnique Fédérale de Lausanne.
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TL;DR: Horseradish peroxidase is an important heme-containing enzyme that has been studied for more than a century as mentioned in this paper, and new information has become available on the three-dimensional structure of the enzyme and its catalytic intermediates, mechanisms of catalysis and function of specific amino acid residues.
1,133 citations
TL;DR: This review describes more than 600 new examples of naturally occurring flavonoids found either as aglycones or glycosides, comprising flavones, flavonols, chalcones, dihydrochalcones and anthocyanidins.
354 citations
TL;DR: This account describes 275 new isoflavonoids published between 2008 and 2011 as constituents of the Leguminosae, commenting on their source, identification, biological activity, synthesis, and ecological or chemosystematic significance.
260 citations
TL;DR: These data provide the first direct evidence for the existence of two distinct substrate interaction sites in LiP, a heme-edge site typical of those encountered in other peroxidases and a second, novel site centered around Trp171 which is required for the oxidation of VA.
Abstract: It has been shown recently that Trp171 of lignin peroxidase (LiP) is hydroxylated at the Cβ position [Blodig, W., Doyle, W. A., Smith, A. T., Winterhalter, K., Choinowski, T., and Piontek, K. (1998) Biochemistry 37, 8832−8838]. Comparative experiments, carried out on both wild-type fungal and recombinant LiP isoenzyme H8 (LiPH8*), indicate that the process of hydroxylation is autocatalytic and that Trp171 may be implicated in catalysis. The role of this residue has therefore been examined using site-directed mutagenesis to obtain recombinant enzymes with Trp171 substituted by Phe or Ser (W171F and W171S LiPH8*, respectively). The wild-type recombinant enzyme (LiPH8*) was analyzed in solution using 1H NMR spectroscopy and its integrity confirmed prior to the kinetic and spectroscopic characterization of LiPH8* mutants. A charge neutralization mutation in the “classical heme edge” substrate access channel of LiP, in which Glu146 was substituted by Gly (E146G LiPH8*), showed substantial activity with respect...
236 citations
TL;DR: In this paper, a novel method was described for the synthesis of oxygenated benzofurans by epoxidation and cyclisation of 2′-hydroxystilbenes, corresponding to the latter were synthesised by Wittig reactions.
178 citations
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TL;DR: Preface to the Princeton Landmarks in Biology Edition vii Preface xi Symbols used xiii 1.
Abstract: Preface to the Princeton Landmarks in Biology Edition vii Preface xi Symbols Used xiii 1. The Importance of Islands 3 2. Area and Number of Speicies 8 3. Further Explanations of the Area-Diversity Pattern 19 4. The Strategy of Colonization 68 5. Invasibility and the Variable Niche 94 6. Stepping Stones and Biotic Exchange 123 7. Evolutionary Changes Following Colonization 145 8. Prospect 181 Glossary 185 References 193 Index 201
14,171 citations
TL;DR: Some of the recent advances in flavonoid research are reviewed and the role of anthocyanins and flavones in providing stable blue flower colours in the angiosperms is outlined.
3,465 citations
TL;DR: Flavonoids are plant pigments that are synthesised from phenylalanine, generally display marvelous colors known from flower petals, mostly emit brilliant fluorescence when they are excited by UV light, and are ubiquitous to green plant cells.
2,424 citations
TL;DR: This study provides direct comparative data on antioxidant capacity and total and individual phenolics contents of the 26 spice extracts and showed that phenolic compounds in the tested spices contributed significantly to their antioxidant capacity.
Abstract: Total equivalent antioxidant capacity (TEAC) and phenolic content of 26 common spice extracts from 12 botanical families were investigated. Qualitative and quantitative analyses of major phenolics in the spice extracts were systematically conducted by reversed-phase high-performance liquid chromatography (RP-HPLC). Many spices contained high levels of phenolics and demonstrated high antioxidant capacity. Wide variation in TEAC values (0.55−168.7 mmol/100 g) and total phenolic content (0.04−14.38 g of gallic acid equivalent/100 g) was observed. A highly positive linear relationship (R2 = 0.95) obtained between TEAC values and total phenolic content showed that phenolic compounds in the tested spices contributed significantly to their antioxidant capacity. Major types of phenolic constituents identified in the spice extracts were phenolic acids, phenolic diterpenes, flavonoids, and volatile oils (e.g., aromatic compounds). Rosmarinic acid was the dominant phenolic compound in the six spices of the family La...
1,315 citations
TL;DR: Results indicate that L. aromatica can be used in dietary applications with a potential to reduce oxidative stress.
1,176 citations