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Nigel Garrett
Researcher at Centre for the AIDS Programme of Research in South Africa
Publications - 105
Citations - 3689
Nigel Garrett is an academic researcher from Centre for the AIDS Programme of Research in South Africa. The author has contributed to research in topics: Medicine & Viral load. The author has an hindex of 23, co-authored 73 publications receiving 2642 citations. Previous affiliations of Nigel Garrett include Barts Health NHS Trust & Queen Mary University of London.
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Journal ArticleDOI
Developmental pathway for potent V1V2-directed HIV-neutralizing antibodies.
Nicole A. Doria-Rose,Chaim A. Schramm,Jason Gorman,Penny L. Moore,Jinal N. Bhiman,Brandon J. DeKosky,Michael J. Ernandes,Ivelin S. Georgiev,Helen J. Kim,Marie Pancera,Ryan P. Staupe,Han Altae-Tran,Robert T. Bailer,Ema T. Crooks,Albert Cupo,Aliaksandr Druz,Nigel Garrett,Kam Hon Hoi,Rui Kong,Mark K. Louder,Nancy S. Longo,Krisha McKee,Molati Nonyane,Sijy O'Dell,Ryan S. Roark,Rebecca S. Rudicell,Stephen D. Schmidt,Daniel J. Sheward,Cinque Soto,Constantinos Kurt Wibmer,Yongping Yang,Zhenhai Zhang,Nisc Comparative Sequencing,James C. Mullikin,James M. Binley,Rogier W. Sanders,Ian A. Wilson,John P. Moore,Andrew B. Ward,George Georgiou,Carolyn Williamson,Salim S. Abdool Karim,Lynn Morris,Peter D. Kwong,Lawrence Shapiro,John R. Mascola +45 more
TL;DR: HIV-1 V1V2-directed neutralizing antibodies can develop relatively rapidly through initial selection of B cells with a long CDR H3, and limited subsequent somatic hypermutation, and provide important insights relevant to HIV-1 vaccine development.
Journal ArticleDOI
Genital Inflammation and the Risk of HIV Acquisition in Women
Lindi Masson,Lindi Masson,Jo-Ann S. Passmore,Jo-Ann S. Passmore,Lenine J. P. Liebenberg,Lise. Werner,Cheryl Baxter,Kelly B. Arnold,Carolyn Williamson,Carolyn Williamson,Francesca Little,Leila E. Mansoor,Vivek Naranbhai,Douglas A. Lauffenburger,Katharina Ronacher,Gerhard Walzl,Nigel Garrett,Brent L. Williams,Mara Couto-Rodriguez,Mady Hornig,W. Ian Lipkin,Anneke Grobler,Quarraisha Abdool Karim,Quarraisha Abdool Karim,Salim S. Abdool Karim,Salim S. Abdool Karim +25 more
TL;DR: Elevated genital concentrations of HIV target cell-recruiting chemokines and a genital inflammatory profile contributes to the high risk of HIV acquisition in these African women.
Journal ArticleDOI
Evaluation of a mosaic HIV-1 vaccine in a multicentre, randomised, double-blind, placebo-controlled, phase 1/2a clinical trial (APPROACH) and in rhesus monkeys (NHP 13-19)
Dan H. Barouch,Dan H. Barouch,Frank Tomaka,Frank Wegmann,Daniel J. Stieh,Galit Alter,Merlin L. Robb,Merlin L. Robb,Nelson L. Michael,Lauren Peter,Joseph P. Nkolola,Erica N. Borducchi,Abishek Chandrashekar,David Jetton,Kathryn E. Stephenson,Kathryn E. Stephenson,Wenjun Li,Bette T. Korber,Georgia D. Tomaras,David C. Montefiori,Glenda Gray,Nicole Frahm,M. Juliana McElrath,Lindsey R. Baden,Jennifer Johnson,Julia Hutter,Edith Swann,Etienne Karita,Hannah Kibuuka,Juliet Mpendo,Nigel Garrett,Kathy Mngadi,Kundai Chinyenze,Frances Priddy,Erica Lazarus,Fatima Laher,Sorachai Nitayapan,Punnee Pitisuttithum,Stephan Bart,Thomas B. Campbell,Robert Feldman,Gregg Lucksinger,Caroline Borremans,Katleen Callewaert,Raphaele Roten,Jerald C. Sadoff,Lorenz Scheppler,Mo Weijtens,Karin Feddes-de Boer,Danielle van Manen,Jessica Vreugdenhil,Roland Zahn,Ludo Lavreys,Steven Nijs,Jeroen Tolboom,Jenny Hendriks,Zelda Euler,Maria G. Pau,Hanneke Schuitemaker +58 more
TL;DR: All vaccine regimens demonstrated favourable safety and tolerability and immunogenicity and protective efficacy against a series of six repetitive, heterologous, intrarectal challenges with a rhesus peripheral blood mononuclear cell-derived challenge stock of simian-human immunodeficiency virus (SHIV-SF162P3).
Journal ArticleDOI
New Member of the V1V2-Directed CAP256-VRC26 Lineage That Shows Increased Breadth and Exceptional Potency
Nicole A. Doria-Rose,Jinal N. Bhiman,Jinal N. Bhiman,Ryan S. Roark,Chaim A. Schramm,Jason Gorman,Gwo-Yu Chuang,Marie Pancera,Evan M. Cale,Michael J. Ernandes,Mark K. Louder,Mangaiarkarasi Asokan,Robert T. Bailer,Aliaksandr Druz,Isabella R. Fraschilla,Nigel Garrett,Marissa C. Jarosinski,Rebecca M. Lynch,Krisha McKee,Sijy O'Dell,Amarendra Pegu,Stephen D. Schmidt,Ryan P. Staupe,Matthew S. Sutton,Keyun Wang,Constantinos Kurt Wibmer,Constantinos Kurt Wibmer,Barton F. Haynes,Salim Abdool-Karim,Salim Abdool-Karim,Lawrence Shapiro,Peter D. Kwong,Penny L. Moore,Penny L. Moore,Penny L. Moore,Lynn Morris,Lynn Morris,Lynn Morris,John R. Mascola +38 more
TL;DR: The results highlight the ongoing evolution within a single antibody lineage and describe more potent and broadly neutralizing members with potential clinical utility, particularly in areas where clade C is prevalent.
Journal ArticleDOI
Viral variants that initiate and drive maturation of V1V2-directed HIV-1 broadly neutralizing antibodies
Jinal N. Bhiman,Jinal N. Bhiman,Colin Anthony,Nicole A. Doria-Rose,Owen. Karimanzira,Chaim A. Schramm,Thandeka. Khoza,Dale Kitchin,Gordon Botha,Jason Gorman,Nigel Garrett,Salim S. Abdool Karim,Lawrence Shapiro,Lawrence Shapiro,Carolyn Williamson,Carolyn Williamson,Peter D. Kwong,John R. Mascola,Lynn Morris,Lynn Morris,Lynn Morris,Penny L. Moore,Penny L. Moore,Penny L. Moore +23 more
TL;DR: Early viral escape at key antibody-virus contact sites selects for antibody sublineages that can tolerate these changes, thereby providing a mechanism for the generation of neutralization breadth within a developing antibody lineage.