N
Nigel Klein
Researcher at UCL Institute of Child Health
Publications - 581
Citations - 25603
Nigel Klein is an academic researcher from UCL Institute of Child Health. The author has contributed to research in topics: Population & Medicine. The author has an hindex of 81, co-authored 551 publications receiving 23353 citations. Previous affiliations of Nigel Klein include French Institute of Health and Medical Research & UCL Institute of Ophthalmology.
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Journal ArticleDOI
Oligosaccharides in Human Milk: Structural, Functional, and Metabolic Aspects
TL;DR: Research on HMOs is certainly needed to increase the knowledge of infant nutrition as it is affected by complex oligosaccharides, but more is needed to know about the metabolism of oligosACcharides in the gastrointestinal tract.
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School-age outcomes in children with birth weights under 750 g
Maureen Hack,H. G. Taylor,Nigel Klein,R Eiben,Christopher Schatschneider,Nori Mercuri-Minich +5 more
TL;DR: Children with birth weights under 750 g were inferior to both comparison groups in cognitive ability, psychomotor skills, and academic achievement and had poorer social skills and adaptive behavior and more behavioral and attention problems.
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Mental Stress Induces Transient Endothelial Dysfunction in Humans
Lorenzo Ghiadoni,Ann E. Donald,Mark Cropley,Michael J. Mullen,G. Oakley,Mia Taylor,Georgina O’Connor,John Betteridge,Nigel Klein,Andrew Steptoe,John E. Deanfield +10 more
TL;DR: These findings suggest that brief episodes of mental stress, similar to those encountered in everyday life, may cause transient endothelial dysfunction in healthy young individuals and might represent a mechanistic link between mental stress and atherogenesis.
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Mannose-Binding Lectin Binds to a Range of Clinically Relevant Microorganisms and Promotes Complement Deposition
TL;DR: It is concluded that MBL may be of importance in first-line immune defense against several important pathogens in immunocompromised children.
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Regulatory B cells are induced by gut microbiota-driven interleukin-1β and interleukin-6 production.
Elizabeth C. Rosser,Kristine Oleinika,Silvia Tonon,Ronan Doyle,Anneleen Bosma,Natalie A. Carter,Kathryn A. Harris,Simon Arnett Jones,Nigel Klein,Claudia Mauri +9 more
TL;DR: It is shown that the gut microbiota promotes the differentiation of Breg cells in the spleen as well as in the mesenteric lymph nodes, in response to inflammatory signals induced by both the gut flora and arthritis.