Author
Nigel Smith
Bio: Nigel Smith is an academic researcher from The Hertz Corporation. The author has contributed to research in topics: Gadolinium & Bone healing. The author has an hindex of 1, co-authored 2 publications receiving 325 citations.
Topics: Gadolinium, Bone healing
Papers
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TL;DR: Results highlight the sensitivity of healing response to Si level and suggest that an optimal response is obtained when SA is substituted with 0.8 wt% Si through its effect on the activity of both bone forming and bone resorbing cells.
343 citations
Patent•
07 Jun 2006
TL;DR: A synthetic calcium phosphate-based biomedical material comprising gadolinium is in the form of Gd ions as mentioned in this paper, and the phase purity of the biomedical material may be at least 95%.
Abstract: A synthetic calcium phosphate based biomedical material comprises gadolinium. At least some of the gadolinium is in the form of Gd ions. The biomedical material may further comprise silicon and/or silicate. The material may comprise a compound having the general chemical formula Ca10-yGdy(PO4)6-x(SiO4)x(OH)2-x+y where 0 < x < 1.3 and 0 < y < 1.3. The phase purity of the biomedical material may be at least 95%. Also claimed is a biomedical material comprising a synthetic gadolinium-silicate co-substituted calcium phosphate based material. Also there is a process disclosed for making the biomedical materials comprising providing calcium or calcium containing compound, a gadolinium containing compound, a phosphorus containing compound and optionally a silicon containing compound and forming a precipitate by reacting the compounds in an aqueous phase at an alkali pH.
1 citations
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TL;DR: Silicon (Si) substitution in the crystal structures of calcium phosphate (CaP) ceramics such as hydroxyapatite (HA) and tricalcium phosphate (TCP) generates materials with superior biological performance to stoichiometric counterparts.
601 citations
TL;DR: The purpose of the review is to assess state of the art and future perspectives of the so called "smart biomaterials" from a translational science and specifically clinical point of view and to filter out and discuss which biomedical advances and innovations help to achieve the objective to translate smart biomMaterials from bench to bedside.
428 citations
TL;DR: This review highlights the use of trace elements in CaP biomaterials, and offers an insight into the mechanisms of how metal ions can enhance both osteogenesis and angiogenesis.
387 citations
TL;DR: It is illustrated that inorganics can positively affect bone healing but various factors make literature comparisons difficult and Bioinorganics have the potential to have just as big an impact on bone regeneration as recombinant proteins without some of the safety concerns and high costs.
363 citations
01 Dec 2010
TL;DR: A review considers the application of available bone grafts in different clinical settings and discusses recently introduced bioactive biomaterials and highlights the clinical difficulties and technological deficiencies that exist in current surgical practice.
Abstract: As the population ages, the number of operations performed on bone is expected to increase. Diseases such as arthritis, tumours, and trauma can lead to defects in the skeleton requiring an operation to replace or restore the lost bone. Surgeons can use autografts, allografts, and/or bone graft substitutes to restore areas of bone loss. Surgical implants are also used in addition or in isolation to replace the diseased bone. This review considers the application of available bone grafts in different clinical settings. It also discusses recently introduced bioactive biomaterials and highlights the clinical difficulties and technological deficiencies that exist in our current surgical practice.
348 citations