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Nigel Vivian
Researcher at National Institute for Medical Research
Publications - 9
Citations - 7257
Nigel Vivian is an academic researcher from National Institute for Medical Research. The author has contributed to research in topics: Y chromosome & Testis determining factor. The author has an hindex of 9, co-authored 9 publications receiving 6930 citations. Previous affiliations of Nigel Vivian include Medical Research Council.
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Journal ArticleDOI
Multipotent cell lineages in early mouse development depend on SOX2 function
Ariel A. Avilion,Silvia K. Nicolis,Larysa H. Pevny,Lidia Pérez,Nigel Vivian,Robin Lovell-Badge +5 more
TL;DR: The data suggest that maternal components could be involved in establishing early cell fate decisions and that a combinatorial code, requiring SOX2 and OCT4, specifies the first three lineages present at implantation.
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Male development of chromosomally female mice transgenic for Sry
TL;DR: It is shown that Sry on a 14-kilobase genomic DNA fragment is sufficient to induce testis differentiation and subsequent male development when introduced into chromosomally female mouse embryos.
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A gene mapping to the sex-determining region of the mouse Y chromosome is a member of a novel family of embryonically expressed genes
John Gubbay,Jérôme Collignon,Peter Koopman,Blanche Capel,Androulla Economou,Andrea Münsterberg,Nigel Vivian,Peter N. Goodfellow,Robin Lovell-Badge +8 more
TL;DR: A gene mapping to the sex-determining region of the mouse Y chromosome is deleted in a line of XY female mice mutant for Tdy, and is expressed at a stage during male gonadal development consistent with its having a role in testis determination.
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Expression of a candidate sex-determining gene during mouse testis differentiation
TL;DR: The observations strongly support a primary role for Sry in mouse sex determination, and further the involvement of this gene, Sry, in testis development, which is studied in detail.
Journal ArticleDOI
Inverted repeat structure of the Sry locus in mice.
John Gubbay,Nigel Vivian,Androulla Economou,David C. Jackson,Peter N. Goodfellow,Robin Lovell-Badge +5 more
TL;DR: Detailed analysis of the Sry genomic locus reveals a further difference in that the mouse Sry open reading frame lies within 2.8 kilobases of unique sequence at the center of a large inverted repeat.