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Nikunj V. Somia
Researcher at University of Minnesota
Publications - 41
Citations - 7573
Nikunj V. Somia is an academic researcher from University of Minnesota. The author has contributed to research in topics: Gene & Genetic enhancement. The author has an hindex of 19, co-authored 40 publications receiving 7183 citations. Previous affiliations of Nikunj V. Somia include Salk Institute for Biological Studies & University of Edinburgh.
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Journal ArticleDOI
Gene therapy -- promises, problems and prospects
Inder M. Verma,Nikunj V. Somia +1 more
TL;DR: The prospects are good — by the year 2010, gene therapy may be as routine a practice as heart transplants are today.
Journal ArticleDOI
Efficient design and assembly of custom TALEN and other TAL effector-based constructs for DNA targeting
Tomas Cermak,Erin L. Doyle,Michelle Christian,Li-Li Wang,Yong Zhang,Clarice Schmidt,Joshua A. Baller,Nikunj V. Somia,Adam J. Bogdanove,Daniel F. Voytas +9 more
TL;DR: A method and reagents for efficiently assembling TALEN constructs with custom repeat arrays are presented and design guidelines based on naturally occurring TAL effectors and their binding sites are described.
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Non-ATG–initiated translation directed by microsatellite expansions
Tao Zu,Brian Gibbens,Noelle S. Doty,Mário Gomes-Pereira,Aline Huguet,Matthew D. Stone,Jamie M. Margolis,Mark Peterson,Todd W. Markowski,Melissa Ingram,Zhenhong Nan,Colleen L. Forster,Walter C. Low,Benedikt Schoser,Nikunj V. Somia,H. Brent Clark,Stephen C. Schmechel,Peter B. Bitterman,Geneviève Gourdon,Maurice S. Swanson,Melinda L. Moseley,Laura P.W. Ranum +21 more
TL;DR: It is shown that RAN translation across human spinocerebellar ataxia type 8 (SCA8) and myotonic dystrophy type 1 (DM1) CAG expansion transcripts results in the accumulation of SCA8 polyalanine and DM1 polyglutamine expansion proteins in previously established mouse models and human tissue.
Journal ArticleDOI
Gene therapy: trials and tribulations
Nikunj V. Somia,Inder M. Verma +1 more
TL;DR: A key problem in gene therapy is the lack of a vector system that fulfils all the requirements for safety and efficacy, and viral vectors are the most promising vectors at this time.
Journal ArticleDOI
Erratum: Efficient design and assembly of custom TALEN and other TAL effector-based constructs for DNA targeting (Nucleic Acids Research (2011) 39 (e82) DOI: 10.1093/nar/gkr218)
Tomas Cermak,Erin L. Doyle,Michelle Christian,Li Wang,Yong Zhang,Clarice Schmidt,Joshua A. Baller,Nikunj V. Somia,Adam J. Bogdanove,Daniel F. Voytas +9 more