N
Nilesh J. Samani
Researcher at University of Leicester
Publications - 836
Citations - 127518
Nilesh J. Samani is an academic researcher from University of Leicester. The author has contributed to research in topics: Genome-wide association study & Population. The author has an hindex of 149, co-authored 779 publications receiving 113545 citations. Previous affiliations of Nilesh J. Samani include University Hospitals of Leicester NHS Trust & Glenfield Hospital.
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Journal ArticleDOI
LGALS2 functional variant rs7291467 is not associated with susceptibility to myocardial infarction in Caucasians.
Massimo Mangino,Peter S. Braund,Ravi K. Singh,Richard P. Steeds,John R. Thompson,Kevin S Channer,Nilesh J. Samani +6 more
TL;DR: It is found that there is no significant association of allele frequency with risk of MI, and Stratification for age, gender and other cardiovascular risk factors also failed to reveal an association of this polymorphism with MI.
Journal ArticleDOI
Association of Chromosome 9p21 with Subsequent Coronary Heart Disease Events: A GENIUS-CHD Study of Individual Participant Data
Riyaz S. Patel,Amand F. Schmidt,Vinicius Tragante,Raymond O McCubrey,Michael V. Holmes,Michael V. Holmes,Michael V. Holmes,Laurence J. Howe,Kenan Direk,Axel Åkerblom,Karin Leander,Salim S. Virani,Karol Kamiński,Jochen D. Muehlschlegel,Marie-Pierre Dubé,Hooman Allayee,Peter Almgren,Maris Alver,Ekaterina V Baranova,Hassan Behlouli,Bram Boeckx,Peter S. Braund,Peter S. Braund,Lutz P. Breitling,Graciela E. Delgado,Nubia E. Duarte,Line Dufresne,Niclas Eriksson,Luisa Foco,Crystel M. Gijsberts,Yan Gong,Jaana Hartiala,Mahyar Heydarpour,Mahyar Heydarpour,Jaroslav A. Hubacek,Marcus E. Kleber,Daniel Kofink,Pekka Kuukasjärvi,Vei-Vei Lee,Andreas Leiherer,Petra A. Lenzini,Daniel Levin,Leo-Pekka Lyytikäinen,Nicola Martinelli,Ute Mons,Christopher P. Nelson,Christopher P. Nelson,Kjell Nikus,Anna P. Pilbrow,Rafał Płoski,Yan V. Sun,Michael W.T. Tanck,W.H. Wilson Tang,Stella Trompet,Sander W. van der Laan,Jessica van Setten,Ragnar O. Vilmundarson,Chiara Viviani Anselmi,Efthymia Vlachopoulou,Eric Boerwinkle,Carlo Briguori,John F. Carlquist,Kathryn F. Carruthers,Gavino Casu,John E. Deanfield,Panos Deloukas,Frank Dudbridge,Natalie K Fitzpatrick,Bruna Gigante,Stefan James,Marja-Liisa Lokki,Paulo A. Lotufo,Nicola Marziliano,Ify Mordi,Joseph B. Muhlestein,Chris Newton Cheh,Jan Pitha,Christoph H. Saely,Ayman Samman-Tahhan,Pratik B. Sandesara,Andrej Teren,Adam Timmis,Adam Timmis,Frans Van de Werf,Els Wauters,Arthur A.M. Wilde,Ian Ford,David J. Stott,Ale Algra,Maria G. Andreassi,Diego Ardissino,Benoit J. Arsenault,Christie M. Ballantyne,Thomas O. Bergmeijer,Connie R. Bezzina,Simon C. Body,Simon C. Body,Peter Bogaty,Gert J. de Borst,Hermann Brenner,Ralph Burkhardt,Clara Carpeggiani,Gianluigi Condorelli,Rhonda M. Cooper-DeHoff,Sharon Cresci,Ulf de Faire,Robert N. Doughty,Heinz Drexel,James C. Engert,Keith A.A. Fox,Domenico Girelli,Emil Hagström,Stanley L. Hazen,Stanley L. Hazen,Claes Held,Harry Hemingway,Imo E. Hoefer,G. Kees Hovingh,Julie A. Johnson,Pim A. de Jong,J. Wouter Jukema,J. Wouter Jukema,Marcin P. Kaczor,Mika Kähönen,Jiri Kettner,Marek Kiliszek,Olaf H. Klungel,Bo Lagerqvist,Diether Lambrechts,Jari Laurikka,Terho Lehtimäki,Dan Lindholm,Bakhtawar K. Mahmoodi,Anke H. Maitland-van der Zee,Anke H. Maitland-van der Zee,Ruth McPherson,Olle Melander,Andres Metspalu,Witold Pepinski,Oliviero Olivieri,Grzegorz Opolski,Colin N. A. Palmer,Gerard Pasterkamp,Carl J. Pepine,Alexandre C. Pereira,Louise Pilote,Arshed A. Quyyumi,A. Mark Richards,A. Mark Richards,Marek Sanak,Markus Scholz,Agneta Siegbahn,Juha Sinisalo,J. Gustav Smith,John A. Spertus,Alexandre F.R. Stewart,Wojciech Szczeklik,Anna Szpakowicz,Jurriën M. ten Berg,George Thanassoulis,George Thanassoulis,Joachim Thiery,Yolanda van der Graaf,Frank L.J. Visseren,Johannes Waltenberger,Pim van der Harst,Jean-Claude Tardif,Naveed Sattar,Chim C. Lang,Guillaume Paré,Guillaume Paré,James M. Brophy,Jeffrey L. Anderson,Winfried März,Winfried März,Winfried März,Lars Wallentin,Vicky A. Cameron,Benjamin D. Horne,Nilesh J. Samani,Aroon D. Hingorani,Folkert W. Asselbergs +181 more
TL;DR: The association with subsequent revascularization may support the postulated mechanism of chromosome 9p21 for promoting atheroma development in individuals with established CHD and disease-free controls.
Journal ArticleDOI
Neutrophil-to-lymphocyte ratio and outcomes in patients with new-onset or worsening heart failure with reduced and preserved ejection fraction.
Fraser M Curran,U Bhalraam,Mohapradeep Mohan,Jagdeep Singh,Stefan D. Anker,Kenneth Dickstein,Alex S. F. Doney,Gerasimos Filippatos,Jacob George,Marco Metra,Leong L. Ng,Colin N. A. Palmer,Nilesh J. Samani,Dirk J. van Veldhuisen,Adriaan A. Voors,Chim C. Lang,Ify R. Mordi +16 more
TL;DR: Neutrophil-to-lymphocyte ratio (NLR) is a simple, routinely available measure of inflammation and its relationship with clinical outcomes in addition to other risk markers have not been comprehensively evaluated in heart failure patients as mentioned in this paper.
Posted ContentDOI
Discovery and systematic characterization of risk variants and genes for coronary artery disease in over a million participants
Krishna G. Aragam,Tao Jiang,Anuj Goel,Stavroula Kanoni,Brooke N. Wolford,Elle M. Weeks,Minxian Wang,George Hindy,Zhou W,Christopher Grace,Carolina Roselli,Nicholas A Marston,Kamanu Fk,Ida Surakka,Muñoz Venegas L,Sherliker P,Satoshi Koyama,Kazuyoshi Ishigaki,Michael R. Brown,Ben Michael Brumpton,de Vries Ps,Giannakopoulou O,Giardoglou P,Daniel F. Gudbjartsson,Daniel F. Gudbjartsson,Güldener U,Haider Smi,Helgadottir A,Ibrahim M,Kastrati A,Thorsten Kessler,Li L,Lijiang Ma,Thomas Meitinger,Mucha S,Munz M,Murgia F,Jonas B. Nielsen,Jonas B. Nielsen,Markus M. Nöthen,Pang S,Reinberger T,Gudmar Thorleifsson,von Scheidt M,Ulirsch Jk,Ulirsch Jk,Arnar Do,Arnar Do,Deepak Atri,Deepak Atri,Costanzo Mc,Flannick J,Rajat M. Gupta,Rajat M. Gupta,Ito K,Dongkeun Jang,Yoichiro Kamatani,Amit Khera,Amit Khera,Issei Komuro,Iftikhar J. Kullo,Lotta La,Christopher P. Nelson,Roberts R,Thorgeirsson G,Thorgeirsson G,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Tom R. Webb,Aris Baras,Johan L.M. Björkegren,Johan L.M. Björkegren,Boerwinkle E,Boerwinkle E,George Dedoussis,Hilma Holm,Kristian Hveem,Olle Melander,Alanna C. Morrison,Marju Orho-Melander,Loukianos S. Rallidis,Arno Ruusalepp,Marc S. Sabatine,Kari Stefansson,Kari Stefansson,Pierre Zalloua,Pierre Zalloua,Patrick T. Ellinor,Patrick T. Ellinor,Martin Farrall,Danesh J,Christian T. Ruff,Hilary K. Finucane,Hilary K. Finucane,Jemma C. Hopewell,Robert Clarke,Jeanette Erdmann,Nilesh J. Samani,Heribert Schunkert,Hugh Watkins,Cristen J. Willer,Panagiotis Deloukas,Panagiotis Deloukas,Sekar Kathiresan,Adam S. Butterworth +104 more
TL;DR: In this paper, the authors conducted a genome-wide association study (GWAS) comprising 181,522 cases of coronary artery disease among 1.165,690 participants and detected 241 associations, including 54 associations and 30 loci not previously linked to CAD.
Journal ArticleDOI
Genetic Assessment of Potential Long-Term On-Target Side Effects of PCSK9 (Proprotein Convertase Subtilisin/Kexin Type 9) Inhibitors
Christopher P. Nelson,Florence Lai,Florence Lai,Mintu Nath,Mintu Nath,Shu Ye,Shu Ye,Tom R. Webb,Tom R. Webb,Heribert Schunkert,Nilesh J. Samani,Nilesh J. Samani +11 more
TL;DR: Genetic analyses suggest that long-term use of PCSK9 inhibitors, like statins, may be associated with increased risk of T2DM, and some other potential side effects need to be looked for in future studies of PC SK9 inhibitors.