Nilesh J. Samani

TL;DR: Rates of PPM implantation are lower in South Asians residing in the UK, compared with Caucasians, which raises the possibility of lower inherent susceptibility to bradycardias in South Asia compared with Caucasianians.

TL;DR: Following beta-blocker uptitration, both achieved and change in heart rate were prognostically significant regardless of starting heart rate in SR, however, they were only significant in AF patients with high baseline heart rate.

TL;DR: Factor V Leiden was not associated with increased risk of subsequent atherothrombotic events and mortality in high-risk participants with established and treated CHD, and risk estimates for the secondary outcomes including stroke, coronary revascularization, cardiovascular mortality, and all-cause mortality were close to identity.

TL;DR: In this paper, the authors report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry, identifying 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also highlight shared genetic architecture between blood pressure and lifestyle exposures.

TL;DR: This study provides a deeper understanding of the genetic risk architecture of BAV formation on the single-marker and polygenic level and used the largest human single cell atlas for foetal gene expression to show that the transcriptome profile in endothelial cells is a major source contributing to BAV pathology.