N
Nilesh J. Samani
Researcher at University of Leicester
Publications - 836
Citations - 127518
Nilesh J. Samani is an academic researcher from University of Leicester. The author has contributed to research in topics: Genome-wide association study & Population. The author has an hindex of 149, co-authored 779 publications receiving 113545 citations. Previous affiliations of Nilesh J. Samani include University Hospitals of Leicester NHS Trust & Glenfield Hospital.
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Journal ArticleDOI
A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium
Nicole Soranzo,Nicole Soranzo,Tim D. Spector,Massimo Mangino,Brigitte Kühnel,Augusto Rendon,Alexander Teumer,Christina Willenborg,Benjamin J. Wright,Li Chen,Mingyao Li,Perttu Salo,Perttu Salo,Benjamin F. Voight,Benjamin F. Voight,Philippa Burns,Roman A. Laskowski,Yali Xue,Stephan Menzel,David Altshuler,John Bradley,Suzannah Bumpstead,Mary-Susan Burnett,Joseph M. Devaney,Angela Döring,Roberto Elosua,Stephen E. Epstein,Wendy N. Erber,Mario Falchi,Mario Falchi,Stephen F. Garner,Mohammed J. R. Ghori,Alison H. Goodall,Rhian Gwilliam,Hakon Hakonarson,Alistair S. Hall,Naomi Hammond,Christian Hengstenberg,Thomas Illig,Inke R. König,Christopher W. Knouff,Ruth McPherson,Olle Melander,Vincent Mooser,Matthias Nauck,Markku S. Nieminen,Christopher J. O'Donnell,Leena Peltonen,Leena Peltonen,Simon C. Potter,Holger Prokisch,Daniel J. Rader,Catherine M. Rice,Robert Roberts,Veikko Salomaa,Veikko Salomaa,Jennifer G. Sambrook,Stefan Schreiber,Heribert Schunkert,Stephen M. Schwartz,Jovana Serbanovic-Canic,Juha Sinisalo,David S. Siscovick,Klaus Stark,Ida Surakka,Jonathan Stephens,John R. Thompson,Uwe Völker,Henry Völzke,Nicholas A. Watkins,George A. Wells,H-Erich Wichmann,David A. van Heel,Chris Tyler-Smith,Swee Lay Thein,Sekar Kathiresan,Markus Perola,Markus Perola,Muredach P. Reilly,Alexandre F.R. Stewart,Jeanette Erdmann,Nilesh J. Samani,Christa Meisinger,Andreas Greinacher,Panos Deloukas,Willem H. Ouwehand,Willem H. Ouwehand,Christian Gieger +87 more
TL;DR: A long-range haplotype at 12q24 associated with coronary artery disease and myocardial infarction is identified and it is shown that this haplotype demonstrates extensive disease pleiotropy, as it contains known risk loci for type 1 diabetes, hypertension and celiac disease and has been spread by a selective sweep specific to European and geographically nearby populations.
Journal ArticleDOI
New susceptibility locus for coronary artery disease on chromosome 3q22.3
Jeanette Erdmann,Anika Großhennig,Peter S. Braund,Inke R. König,Christian Hengstenberg,Alistair S. Hall,Patrick Linsel-Nitschke,Sekar Kathiresan,Ben J Wright,David-Alexandre Trégouët,François Cambien,Petra Bruse,Zouhair Aherrahrou,Arnika Kathleen Wagner,Klaus Stark,Stephen M. Schwartz,Veikko Salomaa,Roberto Elosua,Olle Melander,Benjamin F. Voight,Christopher J. O'Donnell,Leena Peltonen,David S. Siscovick,David Altshuler,Piera Angelica Merlini,Flora Peyvandi,Luisa Bernardinelli,Luisa Bernardinelli,Diego Ardissino,Arne Schillert,Stefan Blankenberg,Tanja Zeller,Philipp S. Wild,Daniel F Schwarz,Laurence Tiret,Claire Perret,Stefan Schreiber,Nour Eddine El Mokhtari,Arne Schäfer,Winfried März,Winfried März,Winfried März,Wilfried Renner,Peter Bugert,Harald Klüter,Jürgen Schrezenmeir,Diana Rubin,Stephen G. Ball,Anthony J. Balmforth,H-Erich Wichmann,Thomas Meitinger,Marcus Fischer,Christa Meisinger,Jens Baumert,Annette Peters,Willem H. Ouwehand,Panos Deloukas,John R. Thompson,Andreas Ziegler,Nilesh J. Samani,Heribert Schunkert +60 more
TL;DR: A three-stage analysis of genome-wide SNP data in 1,222 German individuals with myocardial infarction and 1,298 controls is presented and suggestive association with a locus on 12q24.31 near HNF1A-C12orf43 is identified.
Genome-wide association analyses identify 18 new loci associated with serum urate concentrations
Anna Koettgen,Eva Albrecht,Alexander Teumer,Veronique Vitart,Jan Krumsiek,Claudia Hundertmark,Giorgio Pistis,Daniela Ruggiero,Conall M. O'Seaghdha,Toomas Haller,Qiong Yang,Toshiko Tanaka,Andrew D. Johnson,Zoltán Kutalik,Albert V. Smith,Julia Shi,Maksim Struchalin,Rita P. S. Middelberg,Morris J. Brown,Angelo L. Gaffo,Nicola Pirastu,Guo Li,Caroline Hayward,Tatijana Zemunik,Jennifer E. Huffman,Loic Yengo,Jing Hua Zhao,Ayse Demirkan,Mary F. Feitosa,Xuan Liu,Giovanni Malerba,Lorna M. Lopez,Pim van der Harst,Xinzhong Li,Marcus E. Kleber,Andrew A. Hicks,Ilja M. Nolte,Åsa Johansson,Federico Murgia,Sarah H. Wild,Stephan J. L. Bakker,John F. Peden,Abbas Dehghan,Maristella Steri,Albert Tenesa,Vasiliki Lagou,Perttu Salo,Massimo Mangino,Lynda M. Rose,Terho Lehtimäki,Owen M. Woodward,Yukinori Okada,Adrienne Tin,Christian Mueller,Christopher Oldmeadow,Margus Putku,Darina Czamara,Peter Kraft,Laura Frogheri,Gian Andri Thun,Anne Grotevendt,Gauti Kjartan Gislason,Tamara B. Harris,Lenore J. Launer,Patrick F. McArdle,Alan R. Shuldiner,Eric Boerwinkle,Josef Coresh,Helena Schmidt,Michael Schallert,Nicholas G. Martin,Grant W. Montgomery,Michiaki Kubo,Yusuke Nakamura,Toshihiro Tanaka,Patricia B. Munroe,Nilesh J. Samani,David R. Jacobs,Kiang Liu,Pio D'Adamo,Sheila Ulivi,Jerome I. Rotter,Bruce M. Psaty,Peter Vollenweider,Gérard Waeber,Susan Campbell,Olivier Devuyst,Pau Navarro,Ivana Kolcic,Nicholas D. Hastie,Beverley Balkau,Philippe Froguel,Tõnu Esko,Andres Salumets,Kay-Tee Khaw,Claudia Langenberg,Nicholas J. Wareham,Aaron Isaacs,Aldi T. Kraja,Qunyuan Zhang,Philipp S. Wild,Rodney J. Scott,Elizabeth G. Holliday,Elin Org,Margus Viigimaa,Stefania Bandinelli,Jeffrey Metter,Antonio Lupo,Elisabetta Trabetti,Rossella Sorice,Angela Doering,Eva Lattka,Konstantin Strauch,Fabian J. Theis,Melanie Waldenberger,H-Erich Wichmann,Gail Davies,Alan J. Gow,Marcel Bruinenberg,Ronald P. Stolk,Jaspal S. Kooner,Weihua Zhang,Bernhard R. Winkelmann,Bernhard O. Boehm,Susanne Lucae,Brenda W.J.H. Penninx,Johannes H. Smit,Gary C. Curhan,Poorva Mudgal,Robert M. Plenge,Laura Portas,Ivana Persico,Mirna Kirin,James F. Wilson,Irene Mateo Leach,Wiek H. van Gilst,Anuj Goel,Halit Ongen,Albert Hofman,Fernando Rivadeneira,André G. Uitterlinden,Medea Imboden,Arnold von Eckardstein,Francesco Cucca,Ramaiah Nagaraja,Maria Grazia Piras,Matthias Nauck,Claudia Schurmann,Kathrin Budde,Florian Ernst,Susan M. Farrington,Evropi Theodoratou,Inga Prokopenko,Michael Stumvoll,Antti Jula,Markus Perola,Veikko Salomaa,So-Youn Shin,Tim D. Spector,Cinzia Sala,Paul M. Ridker,Mika Kaehoenen,Jorma Viikari,Christian Hengstenberg,Christopher P. Nelson,James F. Meschia,Mike A. Nalls,Pankaj Sharma,Andrew B. Singleton,Naoyuki Kamatani,Tanja Zeller,Michel Burnier,John Attia,Maris Laan,Norman Klopp,Hans L. Hillege,Stefan Kloiber,Hyon K. Choi,Mario Pirastu,Silvia Tore,Nicole Probst-Hensch,Henry Voelzke,Vilmundur Gudnason,Afshin Parsa,Reinhold E. Schmidt,John Whitfield,Myriam Fornage,Paolo Gasparini,David S. Siscovick,Ozren Polasek,Harry Campbell,Igor Rudan,Nabila Bouatia-Naji,Andres Metspalu,Ruth J. F. Loos,Cornelia M. van Duijn,Ingrid B. Borecki,Luigi Ferrucci,Giovanni Gambaro,Ian J. Deary,Bruce H. R. Wolffenbuttel,John C. Chambers,Winfried Maerz,Peter P. Pramstaller,Harold Snieder,Ulf Gyllensten,Alan F. Wright,Gerjan Navis,Hugh Watkins,Jacqueline C.M. Witteman,Serena Sanna,Sabine Schipf,Malcolm G. Dunlop,Anke Toenjes,Samuli Ripatti,Nicole Soranzo,Daniela Toniolo,Daniel I. Chasman,Olli T. Raitakari,W. H. Linda Kao,Marina Ciullo,Caroline S. Fox,Mark J. Caulfield,Murielle Bochud,Christian Gieger +224 more
TL;DR: In this article, the authors identified and replicated 28 genome-wide significant loci in association with serum urate concentrations (18 new regions in or near TRIM46, INHBB, SFMBT1, TMEM171, VEGFA, BAZ1B, PRKAG2, STC1, HNF4G, A1CF, ATXN2, UBE2Q2, IGF1R, NFAT5, MAF, HLF, ACVR1B-ACVRL1 and B3GNT4).
Journal ArticleDOI
The transcriptional landscape of age in human peripheral blood
Marjolein J. Peters,Roby Joehanes,Luke C. Pilling,Claudia Schurmann,Claudia Schurmann,Karen N. Conneely,Joseph E. Powell,Eva Reinmaa,George L. Sutphin,Alexandra Zhernakova,Katharina Schramm,Yana A. Wilson,Sayuko Kobes,Taru Tukiainen,Taru Tukiainen,Yolande F. M. Ramos,Harald H H Göring,Myriam Fornage,Yongmei Liu,Sina A. Gharib,Barbara E. Stranger,Philip L. De Jager,Abraham Aviv,Daniel Levy,Joanne M. Murabito,Peter J. Munson,Tianxiao Huan,Albert Hofman,André G. Uitterlinden,Fernando Rivadeneira,Jeroen van Rooij,Lisette Stolk,Linda Broer,Michael M. P. J. Verbiest,Mila Jhamai,Pascal P. Arp,Andres Metspalu,Liina Tserel,Lili Milani,Nilesh J. Samani,Nilesh J. Samani,Pärt Peterson,Silva Kasela,Veryan Codd,Veryan Codd,Annette Peters,Cavin K. Ward-Caviness,Christian Herder,Melanie Waldenberger,Michael Roden,Paula Singmann,Sonja Zeilinger,Thomas Illig,Georg Homuth,Hans J. Grabe,Henry Völzke,Leif Steil,Thomas Kocher,Anna Murray,David Melzer,Hanieh Yaghootkar,Stefania Bandinelli,Eric K. Moses,Jack W. Kent,Joanne E. Curran,Matthew P. Johnson,Sarah Williams-Blangero,Harm-Jan Westra,Harm-Jan Westra,Harm-Jan Westra,Allan F. McRae,Jennifer A. Smith,Sharon L.R. Kardia,Iiris Hovatta,Iiris Hovatta,Markus Perola,Markus Perola,Markus Perola,Samuli Ripatti,Samuli Ripatti,Samuli Ripatti,Veikko Salomaa,Anjali K. Henders,Nicholas G. Martin,Alicia K. Smith,Divya Mehta,Elisabeth B. Binder,K. Maria Nylocks,Elizabeth M. Kennedy,Torsten Klengel,Jingzhong Ding,Astrid Suchy-Dicey,Daniel A. Enquobahrie,Jennifer A. Brody,Jerome I. Rotter,Yii-Der Ida Chen,Jeanine J. Houwing-Duistermaat,Margreet Kloppenburg,P. Eline Slagboom,Quinta Helmer,Wouter den Hollander,Shannon Bean,Towfique Raj,Noman Bakhshi,Qiao-Ping Wang,Lisa J. Oyston,Bruce M. Psaty,Bruce M. Psaty,Russell P. Tracy,Grant W. Montgomery,Stephen T. Turner,John Blangero,Ingrid Meulenbelt,Kerry J. Ressler,Jian Yang,Lude Franke,Johannes Kettunen,Johannes Kettunen,Johannes Kettunen,Peter M. Visscher,G. Gregory Neely,Ron Korstanje,Robert L. Hanson,Holger Prokisch,Luigi Ferrucci,Tõnu Esko,Tõnu Esko,Tõnu Esko,Alexander Teumer,Joyce B. J. van Meurs,Andrew D. Johnson,Mike A. Nalls,Dena G. Hernandez,Dena G. Hernandez,Mark R. Cookson,Raphael Gibbs,Raphael Gibbs,John Hardy,Adaikalavan Ramasamy,Adaikalavan Ramasamy,Alan B. Zonderman,Allissa Dillman,Allissa Dillman,Bryan J. Traynor,Colin Smith,Dan L. Longo,Daniah Trabzuni,Daniah Trabzuni,Juan C. Troncoso,Marcel P. van der Brug,Marcel P. van der Brug,Michael E. Weale,Richard O'Brien,Robert L. Johnson,Robert Walker,Ronald H. Zielke,Sampath Arepalli,Mina Ryten,Andrew B. Singleton +158 more
TL;DR: Differences between transcriptomic age and chronological age are associated with biological features linked to ageing, such as blood pressure, cholesterol levels, fasting glucose, and body mass index and the transcriptomic prediction model adds biological relevance and complements existing epigenetic prediction models.
Journal ArticleDOI
Identification of ADAMTS7 as a novel locus for coronary atherosclerosis and association of ABO with myocardial infarction in the presence of coronary atherosclerosis: two genome-wide association studies
Muredach P. Reilly,Mingyao Li,Jing He,Jane F. Ferguson,Ioannis M. Stylianou,Nehal N. Mehta,Mary Susan Burnett,Joseph M. Devaney,Christopher W. Knouff,John R Thompson,Benjamin D. Horne,Benjamin D. Horne,Alexandre F.R. Stewart,Themistocles L. Assimes,Philipp S. Wild,Hooman Allayee,Patrick Linsel Nitschke,Riyaz S. Patel,Nicola Martinelli,Domenico Girelli,Arshed A. Quyyumi,Jeffrey L. Anderson,Jeffrey L. Anderson,Jeanette Erdmann,Alistair S. Hall,Heribert Schunkert,Thomas Quertermous,Stefan Blankenberg,Stanley L. Hazen,Robert Roberts,Sekar Kathiresan,Nilesh J. Samani,Nilesh J. Samani,Stephen E. Epstein,Daniel J. Rader +34 more
TL;DR: Findings indicate that specific genetic predispositions promote the development of coronary atherosclerosis whereas others lead to myocardial infarction in the presence of coronary Atherosclerosis.