N
Nilesh J. Samani
Researcher at University of Leicester
Publications - 836
Citations - 127518
Nilesh J. Samani is an academic researcher from University of Leicester. The author has contributed to research in topics: Genome-wide association study & Population. The author has an hindex of 149, co-authored 779 publications receiving 113545 citations. Previous affiliations of Nilesh J. Samani include University Hospitals of Leicester NHS Trust & Glenfield Hospital.
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Journal ArticleDOI
Using matrix assisted laser desorption ionisation mass spectrometry (MALDI-MS) profiling in order to predict clinical outcomes of patients with heart failure.
Thong Huy Cao,Donald J.L. Jones,Donald J.L. Jones,Paulene A. Quinn,Daniel Chu Siong Chan,Narayan Hafid,Helen M. Parry,Mohapradeep Mohan,Jatinderpal K. Sandhu,Stefan D. Anker,John G.F. Cleland,Kenneth Dickstein,Gerasimos Filippatos,Hans L. Hillege,Marco Metra,Piotr Ponikowski,Nilesh J. Samani,Dirk J. van Veldhuisen,Faiez Zannad,Aeilko H. Zwinderman,Adriaan A. Voors,Chim C. Lang,Leong L. Ng +22 more
TL;DR: The results obtained in this study suggest that a cluster of plasma peptides using MALDI-MS can reliably predict clinical outcomes in HF that may help enable precision medicine in HF.
Journal ArticleDOI
Pathophysiologic Processes and Novel Biomarkers Associated With Congestion in Heart Failure.
Paloma Pandhi,Jozine M. ter Maaten,Stefan D. Anker,Leong L. Ng,Marco Metra,Nilesh J. Samani,Chim C. Lang,Kenneth Dickstein,W. De Boer,Dirk J. van Veldhuisen,Adriaan A. Voors,Iziah E Sama +11 more
TL;DR: In this article , a congestion score (sum of jugular venous pressure, orthopnea, and peripheral edema) was calculated in 1,245 BIOSTAT-CHF patients with acute or worsening congestive heart failure.
Posted ContentDOI
Genetic analysis of over one million people identifies 535 novel loci for blood pressure
Evangelos Evangelou,Evangelos Evangelou,Helen R. Warren,Helen R. Warren,David Mosen-Ansorena,Borbala Mifsud,Raha Pazoki,He Gao,Georgios Ntritsos,Niki Dimou,Claudia P. Cabrera,Claudia P. Cabrera,Ibrahim Karaman,Fu Liang Ng,Marina Evangelou,K. Witkowska,Evan Tzanis,Jacklyn N. Hellwege,Ayush Giri,Digna R. Velez Edwards,Yan V. Sun,Kelly Cho,Kelly Cho,J. Michael Gaziano,J. Michael Gaziano,Peter W.F. Wilson,Philip S. Tsao,Csaba P. Kovesdy,Tõnu Esko,Tõnu Esko,Reedik Mägi,Lili Milani,Peter Almgren,Thibaud Boutin,Stéphanie Debette,Jun Ding,Franco Giulianini,Elizabeth G. Holliday,Anne U. Jackson,Ruifang Li-Gao,Wei-Yu Lin,Jian'an Luan,Massimo Mangino,Christopher Oldmeadow,Bram P. Prins,Yong Qian,Muralidharan Sargurupremraj,Nabi Shah,Nabi Shah,Praveen Surendran,Sébastien Thériault,Sébastien Thériault,Niek Verweij,Niek Verweij,Sara M. Willems,Jing Hua Zhao,Philippe Amouyel,John M. C. Connell,Renée de Mutsert,Alex S. F. Doney,Martin Farrall,Martin Farrall,Cristina Menni,Andrew D. Morris,Raymond Noordam,Guillaume Paré,Neil Poulter,Denis C. Shields,Alice Stanton,Simon Thom,Gonçalo R. Abecasis,Najaf Amin,Dan E. Arking,Kristin L. Ayers,Caterina Barbieri,Chiara Batini,Joshua C. Bis,Tineka Blake,Murielle Bochud,Michael Boehnke,Eric Boerwinkle,Dorret I. Boomsma,Erwin P. Bottinger,Peter S. Braund,Marco Brumat,Archie Campbell,Harry Campbell,Aravinda Chakravarti,John C. Chambers,Ganesh Chauhan,Marina Ciullo,Massimiliano Cocca,Francis S. Collins,Heather J. Cordell,Gail Davies,Martin H. de Borst,Eco J. C. de Geus,Ian J. Deary,Joris Deelen,Fabiola M Del Greco,Cumhur Y Demirkale,Marcus Dörr,Georg Ehret,Georg Ehret,Roberto Elosua,Stefan Enroth,A. Mesut Erzurumluoglu,Teresa Ferreira,Mattias Frånberg,Mattias Frånberg,Oscar H. Franco,Ilaria Gandin,Paolo Gasparini,Vilmantas Giedraitis,Christian Gieger,Giorgia Girotto,Anuj Goel,Anuj Goel,Alan J. Gow,Alan J. Gow,Vilmundur Gudnason,Xiuqing Guo,Ulf Gyllensten,Anders Hamsten,Tamara B. Harris,Sarah E. Harris,Catharina A. Hartman,Aki S. Havulinna,Andrew A. Hicks,Edith Hofer,Albert Hofman,Jouke-Jan Hottenga,Jennifer E. Huffman,Shih-Jen Hwang,Erik Ingelsson,Erik Ingelsson,Alan L. James,Rick Jansen,Marjo-Riitta Järvelin,Roby Joehanes,Åsa Johansson,Andrew D. Johnson,Peter K. Joshi,Pekka Jousilahti,J. Wouter Jukema,Antti Jula,Mika Kähönen,Sekar Kathiresan,Sekar Kathiresan,Bernard Keavney,Bernard Keavney,Kay-Tee Khaw,Paul Knekt,Joanne Knight,Ivana Kolcic,Jaspal S. Kooner,Seppo Koskinen,Kati Kristiansson,Zoltán Kutalik,Zoltán Kutalik,Maris Laan,Marty Larson,Lenore J. Launer,Benjamin Lehne,Terho Lehtimäki,Daniel Levy,David C. Liewald,Li Lin,Lars Lind,Cecilia M. Lindgren,Cecilia M. Lindgren,Yongmei Liu,Ruth J. F. Loos,Ruth J. F. Loos,Lorna M. Lopez,Lorna M. Lopez,Lorna M. Lopez,Lingchan Lu,Leo-Pekka Lyytikäinen,Anubha Mahajan,Chrysovalanto Mamasoula,Jaume Marrugat,Jonathan Marten,Yuri Milaneschi,Anna Morgan,Andrew P. Morris,Andrew P. Morris,Alanna C. Morrison,Peter J. Munson,Mike A. Nalls,Priyanka Nandakumar,Christopher P. Nelson,Christopher Newton-Cheh,Teemu J. Niiranen,Ilja M. Nolte,Teresa Nutile,Albertine J. Oldehinkel,Ben A. Oostra,Paul F. O'Reilly,Elin Org,Sandosh Padmanabhan,Sandosh Padmanabhan,Walter Palmas,Arno Palotie,Alison Pattie,Brenda W.J.H. Penninx,Markus Perola,Markus Perola,Markus Perola,Annette Peters,Ozren Polasek,Peter P. Pramstaller,Nguyen Quang Tri,Olli T. Raitakari,Olli T. Raitakari,Meixia Ren,Meixia Ren,Rainer Rettig,Kenneth Rice,Paul M. Ridker,Janina S Reid,Harriëtte Riese,Samuli Ripatti,Antonietta Robino,Lynda M. Rose,Jerome I. Rotter,Igor Rudan,Daniella Ruggiero,Yasaman Saba,Cinzia Sala,Veikko Salomaa,Nilesh J. Samani,Antti-Pekka Sarin,Rheinhold Schmidt,Helena Schmidt,Nick Shrine,David S. Siscovick,Albert V. Smith,Harold Schneider,Siim Sõber,Rossella Sorice,John M. Starr,David J. Stott,David P. Strachan,Rona J. Strawbridge,Johan Sundström,Morris A. Swertz,Kent D. Taylor,Alexander Teumer,Martin D. Tobin,Daniela Toniolo,Michela Traglia,Stella Trompet,Jaakko Tuomilehto,Christophe Tzourio,André G. Uitterlinden,Ahmad Vaez,Ahmad Vaez,Peter J. van der Most,Cornelia M. van Duijn,Anne-Claire Vergnaud,Germaine C. Verwoert,Veronique Vitart,Uwe Völker,Peter Vollenweider,Dragana Vuckovic,Hugh Watkins,Hugh Watkins,Sarah H. Wild,Gonneke Willemsen,James F. Wilson,Alan F. Wright,Jie Yao,Tatijana Zemunik,Weihua Zhang,John Attia,Adam S. Butterworth,Adam S. Butterworth,Daniel I. Chasman,David Conen,Francesco Cucca,John Danesh,John Danesh,Caroline Hayward,Joanna M. M. Howson,Markku Laakso,Edward G. Lakatta,Claudia Langenberg,Ollie Melander,Dennis O. Mook-Kanamori,Patricia B. Munroe,Colin N. A. Palmer,Lorenz Risch,Robert A. Scott,Rodney J. Scott,Peter S. Sever,Tim D. Spector,Pim van der Harst,Nicholas J. Wareham,Eleftheria Zeggini,Morris Brown,Morris Brown,Andres Metspalu,Adriana M. Hung,Christopher J. O'Donnell,Todd L. Edwards,Bruce M. Psaty,Bruce M. Psaty,Ioanna Tzoulaki,Ioanna Tzoulaki,Michael R. Barnes,Michael R. Barnes,Louise V. Wain,Paul Elliott,Mark J. Caulfield,Mark J. Caulfield +315 more
TL;DR: This work identifies 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also reveal shared loci influencing lifestyle exposures that offer the potential for a precision medicine strategy for future cardiovascular disease prevention.
Journal ArticleDOI
Longitudinal telomere length and body composition in healthy term-born infants during the first two years of life.
Kirsten S. de Fluiter,Veryan Codd,Veryan Codd,Matthew Denniff,Gerthe F. Kerkhof,Inge A L P van Beijsterveldt,Laura M Breij,Nilesh J. Samani,Nilesh J. Samani,Marieke Abrahamse-Berkeveld,Anita C. S. Hokken-Koelega +10 more
TL;DR: In this article, the authors measured LTL in blood, expressed as telomere to single-gene copy ratio (T/S ratio), at 3 months and 2 years by quantitative PCR technique.
Journal ArticleDOI
208 The PKC Epsilon/AMPK ALPHA/ENOS Pathway is Implicated as a Mechanism by which Remote Ischaemic Conditioning Attenuates Endothelin-1 Mediated Cardiomyocyte Hypertrophy
A P Vanezis,Chokanan Thaitirarot,Madiha Butt,Iain B. Squire,Nilesh J. Samani,Glenn C. Rodrigo +5 more
TL;DR: Downstream cGMP/PKG is likely to play a prominent role in this anti-hypertrophic effect in rIC, suggesting a broader cardioprotective role for rIC.