N
Nilesh J. Samani
Researcher at University of Leicester
Publications - 836
Citations - 127518
Nilesh J. Samani is an academic researcher from University of Leicester. The author has contributed to research in topics: Genome-wide association study & Population. The author has an hindex of 149, co-authored 779 publications receiving 113545 citations. Previous affiliations of Nilesh J. Samani include University Hospitals of Leicester NHS Trust & Glenfield Hospital.
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Posted ContentDOI
Genome-wide association study provides new insights into the genetic architecture and pathogenesis of heart failure
Sonia Shah,Sonia Shah,Albert Henry,Carolina Roselli,Carolina Roselli,Honghuang Lin,G Sveinbjörnsson,Ghazaleh Fatemifar,Åsa K. Hedman,Jemma B. Wilk,Morley Mp,Chaffin,Anna Helgadottir,Niek Verweij,Niek Verweij,Abbas Dehghan,Peter Almgren,C. Andersson,C. Andersson,Krishna G. Aragam,Krishna G. Aragam,Johan Ärnlöv,Johan Ärnlöv,Joshua D. Backman,Mary L. Biggs,Heather L. Bloom,Jeff Brandimarto,Michael R. Brown,Leonard Buckbinder,David J. Carey,Daniel I. Chasman,Daniel I. Chasman,Xu Chen,Jonathan H. Chung,William A. Chutkow,James P. Cook,Graciela E. Delgado,Spiros Denaxas,Alex S. F. Doney,Marcus Dörr,Samuel C. Dudley,Michael E. Dunn,Gunnar Engström,Tõnu Esko,Tõnu Esko,Stephan B. Felix,Chris Finan,Ian Ford,Mohsen Ghanbari,Sahar Ghasemi,Giedraitis,Franco Giulianini,John S. Gottdiener,Stefan Gross,Daníel F. Guðbjartsson,Daníel F. Guðbjartsson,Rebecca Gutmann,Christopher M. Haggerty,van der Harst P,Craig L. Hyde,Erik Ingelsson,Joop Jukema,Maryam Kavousi,Kay-Tee Khaw,Marcus E. Kleber,Lars Køber,Andrea Koekemoer,Claudia Langenberg,Lars Lind,C M Lindgren,C M Lindgren,C M Lindgren,Barry London,Luca A. Lotta,Ruth C. Lovering,Jian'an Luan,Patrik K. E. Magnusson,Anubha Mahajan,Kenneth B. Margulies,März W,März W,März W,Olle Melander,Ify R. Mordi,Thomas M. Morgan,Thomas M. Morgan,Morris Ad,Morris Ad,Morris Ad,Morris Ap,Alanna C. Morrison,Michael W. Nagle,Christopher P. Nelson,Alexander Niessner,Teemu J. Niiranen,Teemu J. Niiranen,Michelle L. O'Donoghue,Anjali T. Owens,Palmer Cna.,Helen M. Parry,Markus Perola,Eliana Portilla-Fernandez,Bruce M. Psaty,Bruce M. Psaty,Kenneth Rice,Paul M. Ridker,Paul M. Ridker,Romaine Spr.,Jerome I. Rotter,Perttu Salo,Salomaa,Salomaa,van Setten J,Alaa Shalaby,Diane T. Smelser,Nicholas L. Smith,Nicholas L. Smith,Nicholas L. Smith,Stefan Stender,David J. Stott,Peter Svensson,Mari-Liis Tammesoo,Kent D. Taylor,Maris Teder-Laving,Alexander Teumer,Guðmundur Thorgeirsson,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Christian Torp-Pedersen,Stella Trompet,Benoit Tyl,A.G. Uitterlinden,A.G. Uitterlinden,Abirami Veluchamy,Uwe Völker,Adriaan A. Voors,Xiaosong Wang,Nicholas J. Wareham,Dawn M. Waterworth,P.E Weeke,Raul Weiss,Kerri L. Wiggins,Huilin Xing,Laura M. Yerges-Armstrong,Bing Yu,Faiez Zannad,Jing Hua Zhao,Harry Hemingway,Harry Hemingway,Nilesh J. Samani,John J.V. McMurray,Jian Yang,Peter M. Visscher,Christopher Newton-Cheh,Christopher Newton-Cheh,Anders Mälarstig,Anders Mälarstig,Hilma Holm,Steven A. Lubitz,Steven A. Lubitz,Naveed Sattar,Michael V. Holmes,Michael V. Holmes,Michael V. Holmes,Thomas P. Cappola,Folkert W. Asselbergs,Folkert W. Asselbergs,Aroon D. Hingorani,Karoline Kuchenbaecker,Patrick T. Ellinor,Patrick T. Ellinor,Chim C. Lang,Kari Stefansson,Kari Stefansson,Smith Jg,Ramachandran S. Vasan,Daniel I. Swerdlow,Lumbers Rt,Lumbers Rt +178 more
TL;DR: The largest GWAS meta-analysis of HF to-date is reported, comprising 47,309 cases and 930,014 controls, and identifies 12 independent variant associations with HF at 11 genomic loci, all of which demonstrate one or more associations with coronary artery disease, atrial fibrillation, or reduced left ventricular function suggesting shared genetic aetiology.
Journal ArticleDOI
Genomic correlates of glatiramer acetate adverse cardiovascular effects lead to a novel locus mediating coronary risk.
Ingrid Braenne,Lingyao Zeng,Christina Willenborg,Vinicius Tragante,Thorsten Kessler,Cristen J. Willer,Markku Laakso,Lars Wallentin,Paul W. Franks,Veikko Salomaa,Abbas Dehghan,Thomas Meitinger,Nilesh J. Samani,Folkert W. Asselbergs,Jeanette Erdmann,Heribert Schunkert +15 more
TL;DR: Genetic variants that concordantly with the drug increase the risk of CAD are identified by studying genes reported to interact with glatiramer acetate to establish genome-wide significant association with CAD in large human samples.
Journal ArticleDOI
Distinct pathophysiological pathways in women and men with heart failure
Alice Ravera,Bernadet T. Santema,W. De Boer,Stefan D. Anker,Nilesh J. Samani,Chim C. Lang,Leong L. Ng,John G.F. Cleland,Kenneth Dickstein,Carolyn S.P. Lam,Harriette G.C. Van Spall,Gerasimos Filippatos,Dirk J. van Veldhuisen,Marco Metra,Adriaan A. Voors,Iziah E Sama +15 more
TL;DR: This study compared multiple circulating biomarkers to gain better insights into differential HF pathophysiology between women and men.
Posted ContentDOI
Genetic predisposition to myeloproliferative neoplasms implicates hematopoietic stem cell biology
Erik L. Bao,Erik L. Bao,Satish K. Nandakumar,Satish K. Nandakumar,Xiaotian Liao,Xiaotian Liao,Alexander G. Bick,Alexander G. Bick,Juha Karjalainen,Marcin Tabaka,Olga I. Gan,Olga I. Gan,Aki S. Havulinna,Tuomo Kiiskinen,Caleb A. Lareau,Caleb A. Lareau,Aitzkoa Lopez de Lapuente Portilla,Bo Li,Bo Li,Connor A. Emdin,Connor A. Emdin,Veryan Codd,Christopher P. Nelson,Pradeep Natarajan,Pradeep Natarajan,Claire Churchhouse,Björn Nilsson,Björn Nilsson,Peter W.F. Wilson,Peter W.F. Wilson,Kelly Cho,Kelly Cho,Saiju Pyarajan,J. Michael Gaziano,J. Michael Gaziano,Nilesh J. Samani,Million Veteran Program,Aviv Regev,Aarno Palotie,Aarno Palotie,Benjamin M. Neale,John E. Dick,John E. Dick,Christopher J. O'Donnell,Mark J. Daly,Mark J. Daly,Michael Milyavsky,Sekar Kathiresan,Sekar Kathiresan,Vijay G. Sankaran,Vijay G. Sankaran +50 more
TL;DR: The largest genome-wide association study of MPNs to date is conducted and the power of human genetic studies is demonstrated to illuminate a previously unappreciated mechanism for MPN risk through modulation of HSC function.
Journal ArticleDOI
A major polymorphism in the rat SA gene caused by the insertion of a LINE element
TL;DR: 5. Whitehead, A.S., Gallagher, P., Mills, J.L., Kirke, P.M., Weir,D.G., Shields, D.C., Scott,J.H., Selhub, J., Rozen, R.H.