N
Nilesh J. Samani
Researcher at University of Leicester
Publications - 836
Citations - 127518
Nilesh J. Samani is an academic researcher from University of Leicester. The author has contributed to research in topics: Genome-wide association study & Population. The author has an hindex of 149, co-authored 779 publications receiving 113545 citations. Previous affiliations of Nilesh J. Samani include University Hospitals of Leicester NHS Trust & Glenfield Hospital.
Papers
More filters
Journal ArticleDOI
Methylenetetrahydrofolate reductase mutation and coronary artery disease.
TL;DR: In an angiographically assessed cohort of subjects with coronary artery disease participating in a statin regression trial (REGRESS), significantly increased homocysteine concentrations were found in subjects homozygous +/+ or heterozygous (+/−) for the thermolabile variant compared with those carrying only the normal variant (−/−).
Supplementary Material 5
Joshua C. Randall,Thomas W. Winkler,Zoltán Kutalik,Sonja I. Berndt,Anne U. Jackson,Keri L. Monda,Tuomas O. Kilpeläinen,Tõnu Esko,Reedik Mägi,Shengxu Li,Tsegaselassie Workalemahu,Mary F. Feitosa,Damien C. Croteau Chonka,Felix R. Day,Tove Fall,Teresa Ferreira,Stefan Gustafsson,Adam E. Locke,Iain Mathieson,André Scherag,Sailaja Vedantam,Andrew R. Wood,Liming Liang,Valgerdur Steinthorsdottir,Gudmar Thorleifsson,Emmanouil T. Dermitzakis,Antigone S. Dimas,Fredrik Karpe,Josine L. Min,George Nicholson,Deborah J. Clegg,Thomas N. Person,Jon P. Krohn,Sabrina Bauer,Christa Buechler,Kristina Eisinger,Amélie Bonnefond,Philippe Froguel,Jouke-Jan Hottenga,Inga Prokopenko,Lindsay L. Waite,Tamara B. Harris,Albert V. Smith,Alan R. Shuldiner,Wendy L. McArdle,Mark J. Caulfield,Patricia B. Munroe,Henrik Grönberg,Yii-Der Ida Chen,Guo Li,Jacques S. Beckmann,Toby Johnson,Unnur Thorsteinsdottir,Maris Teder-Laving,Kay-Tee Khaw,Nicholas J. Wareham,Jing Hua Zhao,Najaf Amin,Ben A. Oostra,Aldi T. Kraja,Michael A. Province,L. Adrienne Cupples,Nancy L. Heard Costa,Jaakko Kaprio,Samuli Ripatti,Ida Surakka,Francis S. Collins,Jouko Saramies,Jaakko Tuomilehto,Antti Jula,Veikko Salomaa,Jeanette Erdmann,Christian Hengstenberg,Christina Loley,Heribert Schunkert,Claudia Lamina,H.-Erich Wichmann,Eva Albrecht,Christian Gieger,Andrew A. Hicks,Åsa Johansson,Peter P. Pramstaller,Sekar Kathiresan,Elizabeth K. Speliotes,Brenda W.J.H. Penninx,Anna-Liisa Hartikainen,Marjo-Riitta Järvelin,Ulf Gyllensten,Dorret I. Boomsma,Harry Campbell,James F. Wilson,Stephen J. Chanock,Martin Farrall,Anuj Goel,Carolina Medina-Gomez,Fernando Rivadeneira,Karol Estrada,André G. Uitterlinden,Albert Hofman,M. Carola Zillikens,Martin den Heijer,Lambertus A. Kiemeney,Andrea Maschio,Per Hall,Jonathan Tyrer,Alexander Teumer,Henry Völzke,Peter Kovacs,Anke Tönjes,Massimo Mangino,Tim D. Spector,Caroline Hayward,Igor Rudan,Alistair S. Hall,Nilesh J. Samani,Antony P. Attwood,Jennifer G. Sambrook,Joseph Hung,Lyle J. Palmer,Marja-Liisa Lokki,Juha Sinisalo,Gabrielle Boucher,Heikki V. Huikuri,Mattias Lorentzon,Claes Ohlsson,Niina Eklund,Johan G. Eriksson,Cristina Barlassina,Carlo Rivolta,Ilja M. Nolte,Harold Snieder,Melanie M. van der Klauw,Jana V. Van Vliet Ostaptchouk,Pablo V. Gejman,Jianxin Shi,Kevin B. Jacobs,Zhaoming Wang,Stephan J. L. Bakker,Irene Mateo Leach,Gerjan Navis,Pim van der Harst,Nicholas G. Martin,Sarah E. Medland,Grant W. Montgomery,Jian Yang,Daniel I. Chasman,Paul M. Ridker,Lynda M. Rose,Terho Lehtimäki,Olli T. Raitakari,Devin Absher,Carlos Iribarren,Hanneke Basart,Kees Hovingh,Elina Hyppönen,Chris Power,Denise Anderson,John Beilby,Jennie Hui,Jennifer Jolley,Hendrik B. Sager,Stefan R. Bornstein,Peter Schwarz,Kati Kristiansson,Markus Perola,Jaana Lindström,Amy J. Swift,Matti Uusitupa,Mustafa Atalay,Timo A. Lakka,Rainer Rauramaa,Jennifer L. Bolton,Gerry Fowkes,Ross M. Fraser,Jackie F. Price,Krista Fischer,Kaarel KrjutÅ¡kov,Andres Metspalu,Evelin Mihailov,Claudia Langenberg,Jian'an Luan,Ken K. Ong,Peter S. Chines,Sirkka M. Keinanen Kiukaanniemi,Timo Saaristo,Sarah Edkins,Paul W. Franks,Göran Hallmans,Dmitry Shungin,Andrew D. Morris,Colin N. A. Palmer,Raimund Erbel,Susanne Moebus,Markus M. Nöthen,Sonali Pechlivanis,Kristian Hveem,Narisu Narisu,Anders Hamsten,Steve E. Humphries,Rona J. Strawbridge,Elena Tremoli,Harald Grallert,Barbara Thorand,Thomas Illig,Wolfgang Koenig,Martina Müller-Nurasyid,Annette Peters,Bernhard O. Boehm,Marcus E. Kleber,Winfried März,Bernhard R. Winkelmann,Johanna Kuusisto,Markku Laakso,Dominique Arveiler,Giancarlo Cesana,Kari Kuulasmaa,Jarmo Virtamo,John Yarnell,Diana Kuh,Andrew Wong,Lars Lind,Ulf de Faire,Bruna Gigante,Patrik K. E. Magnusson,Nancy L. Pedersen,George Dedoussis,Maria Dimitriou,Genovefa Kolovou,Stavroula Kanoni,Kathleen Stirrups,Lori L. Bonnycastle,Inger Njølstad,Tom Wilsgaard,Andrea Ganna,Emil Rehnberg,Aroon D. Hingorani,Mika Kivimäki,Meena Kumari,Themistocles L. Assimes,Inês Barroso,Michael Boehnke,Ingrid B. Borecki,Panos Deloukas,Caroline S. Fox,Timothy M. Frayling,Leif Groop,Talin Haritunians,David J. Hunter,Erik Ingelsson,Robert C. Kaplan,Karen L. Mohlke,Jeffrey R. O'Connell,David Schlessinger,David P. Strachan,Kari Stefansson,Cornelia M. van Duijn,Gonçalo R. Abecasis,Mark I. McCarthy,Joel N. Hirschhorn,Lu Qi,Ruth J. F. Loos,Cecilia M. Lindgren,Kari E. North,Iris M. Heid +263 more
Journal ArticleDOI
Correction: Corrigendum: Whole-genome sequencing identifies rare genotypes in COMP and CHADL associated with high risk of hip osteoarthritis
Unnur Styrkarsdottir,Hannes Helgason,Asgeir Sigurdsson,Gudmundur L. Norddahl,Arna B Agustsdottir,Louise N. Reynard,Amanda Villalvilla,Gisli H. Halldorsson,Aslaug Jonasdottir,Audur Magnusdottir,Asmundur Oddson,Gerald Sulem,Florian Zink,Gardar Sveinbjornsson,Agnar Helgason,Hrefna Johannsdottir,Anna Helgadottir,Hreinn Stefansson,Solveig Gretarsdottir,Thorunn Rafnar,Ina S. Almdahl,Anne Brækhus,Tormod Fladby,Geir Selbæk,Farhad Hosseinpanah,Fereidoun Azizi,Jung Min Koh,Nelson L.S. Tang,Maryams Danesphour,Jose I. Mayordomo,Corrine K. Welt,Peter S. Braund,Nilesh J. Samani,Lambertus A. Kiemeney,L. Stefan Lohmander,Claus Christiansen,Ole A. Andreassen,Olafur T. Magnusson,Gisli Masson,Augustine Kong,Ingileif Jonsdottir,Daniel F. Gudbjartsson,Patrick Sulem,Helgi Freyr Jónsson,John Loughlin,Thorvaldur Ingvarsson,Unnur Thorsteinsdottir,Kari Stefansson +47 more
TL;DR: This paper presents a meta-analyses of the determinants of infectious disease in eight operation theatres of the central nervous system and shows clear patterns of infection that are consistent with “persistent diarrhoea” and “chronic constipation”.
Journal ArticleDOI
Effects of Coronary Artery Disease–Associated Variants on Vascular Smooth Muscle Cells
Charles U. Solomon,David G. McVey,Catherine Andreadi,Peng Gong,Lenka Turner,Paulina J Stanczyk,Sonja Khemiri,Julie C. Chamberlain,Wei-Chih Yang,Tom R. Webb,Christopher P. Nelson,Nilesh J. Samani,Shu Ye +12 more
TL;DR: A comprehensive analysis shows that a large percentage of CAD loci can modulate gene expression in VSMCs and influence VSMC behavior.
Journal ArticleDOI
Elucidating mechanisms of genetic cross-disease associations at the PROCR vascular disease locus
David Stacey,Lingyan Chen,Paulina J Stanczyk,Joanna M. M. Howson,Amy M. Mason,Stephen Burgess,Stephen MacDonald,Jonathan Langdown,Harriet McKinney,Kate Downes,Neda Farahi,James E. Peters,Saonli Basu,James S. Pankow,Weihong Tang,Nathan Pankratz,Maria Sabater-Lleal,Paul S. de Vries,Nicholas L. Smith,Amy D. Gelinas,Daniel J. Schneider,Nebojsa Janjic,Nilesh J. Samani,Shu Ye,Charlotte Summers,Edwin R. Chilvers,John Danesh,Dirk S. Paul +27 more
TL;DR: In this paper , the authors identify the likely causal variant at the locus and protein C as a causal factor, which is associated with lower coronary artery disease (CAD) risk but higher venous thromboembolism (VTE) risk.