N
Nilesh J. Samani
Researcher at University of Leicester
Publications - 836
Citations - 127518
Nilesh J. Samani is an academic researcher from University of Leicester. The author has contributed to research in topics: Genome-wide association study & Population. The author has an hindex of 149, co-authored 779 publications receiving 113545 citations. Previous affiliations of Nilesh J. Samani include University Hospitals of Leicester NHS Trust & Glenfield Hospital.
Papers
More filters
Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity
Lam C. Tsoi,Sarah L. Spain,Jo Knight,Eva Ellinghaus,Philip E. Stuart,Francesca Capon,Jun Ding,Yun Li,Trilokraj Tejasvi,Johann E. Gudjonsson,Hyun Min Kang,Mariet Allen,Ross McManus,Giuseppe Novelli,Lena Samuelsson,J. Schalkwijk,Mona Ståhle,A D Burden,Catherine H. Smith,Michael J. Cork,Xavier Estivill,Anne M. Bowcock,Gerald G. Krueger,Wolfgang Weger,Jane Worthington,Rachid Tazi-Ahnini,Frank O. Nestle,Adrian Hayday,Per Hoffmann,Juliane Winkelmann,Cisca Wijmenga,Cordelia Langford,Sarah Edkins,Ross M. Andrews,H. D. Blackburn,A. Strange,Richard D. Pearson,Damjan Vukcevic,Chris C. A. Spencer,Panagiotis Deloukas,Ulrich Mrowietz,Stefan Schreiber,Stephan Weidinger,Sulev Kõks,Külli Kingo,Tõnu Esko,Andres Metspalu,Henry W. Lim,John J. Voorhees,Michael Weichenthal,H. E. Wichmann,Vinod Chandran,Cheryl F. Rosen,Proton Rahman,Dafna D. Gladman,Christopher E.M. Griffiths,André Reis,Juha Kere,R. P. Nnair,Andre Franke,J. Barker,Gonçalo R. Abecasis,J. T. Eelder,R. Ttrembath,Kristina Callis Duffin,Cynthia Helms,David E. Goldgar,Justin Paschall,Mary J. Malloy,Clive R. Pullinger,John P. Kane,Jennifer M. Gardner,A. Perlmutter,Andrew Miner,Bing Jian Feng,Ravi Hiremagalore,Robert W. Ike,Enno Christophers,Tilo Henseler,Andreas Ruether,Steven J. Schrodi,Sampath Prahalad,Stephen L. Guthery,Judith Fischer,Wilson Liao,Pui-Yan Kwok,Alan Menter,G.M. Lathrop,Carol Wise,Ann B. Begovich,Alexandros Onoufriadis,Michael E. Weale,Anne C. Hofer,Wolfgang Salmhofer,Philip A. Wolf,Kati Kainu,Ulpu Saarialho-Kere,Sari Suomela,P. Badorf,Ulrike Hüffmeier,Werner Kurrat,Wolfgang Küster,Jesús Lascorz,Rotraut Mössner,Funda Schürmeier-Horst,Markward Ständer,Horst Traupe,Judith G.M. Bergboer,Martin den Heijer,P.C.M. van de Kerkhof,Patrick L.J.M. Zeeuwen,L. Barnes,Linda E. Campbell,Caitriona Cusack,C. M. Coleman,Judith Conroy,Sean Ennis,Oliver FitzGerald,Phil Gallagher,Alan D. Irvine,Brian Kirby,Trevor Markham,Whi McLean,Joseph McPartlin,Sarah Rogers,Anthony W. Ryan,Agnieszka Zawirska,Emiliano Giardina,Tiziana Lepre,Carlo Perricone,Gemma Martin-Ezquerra,Ramon M. Pujol,Eva Riveira-Muñoz,Annica Inerot,Åsa Torinsson Naluai,Lotus Mallbris,Katarina Wolk,Joyce Leman,Anne Barton,Richard B. Warren,Helen S. Young,Isis Ricaño-Ponce,Gosia Trynka,Fawnda Pellett,A. Henschel,M. Aurand,Bruce F. Bebo,Christian Gieger,Thomas Illig,Susanne Moebus,K. H. Jöckel,Raimund Erbel,Peter Donnelly,Leena Peltonen,Jenefer M. Blackwell,Elvira Bramon,Matthew A. Brown,Juan P. Casas,Aiden Corvin,N. Craddock,Audrey Duncanson,Janusz Jankowski,Hugh S. Markus,Christopher G. Mathew,Mark I. McCarthy,Colin N. A. Palmer,Robert Plomin,Anna Rautanen,Stephen Sawcer,Nilesh J. Samani,Ananth C. Viswanathan,Nicholas W. Wood,Céline Bellenguez,Colin Freeman,Garrett Hellenthal,Eleni Giannoulatou,Matti Pirinen,Zhan Su,Sarah E. Hunt,R. Gwilliam,Suzannah Bumpstead,Serge Dronov,Matthew W. Gillman,Erin Gray,Naomi Hammond,Alagurevathi Jayakumar,O. T. McCann,Jennifer Liddle,Maritza Pérez,Simon C. Potter,Radhi Ravindrarajah,Michelle Ricketts,Matthew Waller,Paul A. Weston,Sara Widaa,Pamela Whittaker,R. P. Neir,J.N.W.N. Barker,James T. Elder,Richard C. Trembath +199 more
TL;DR: A meta-analysis of genome-wide association studies and independent data sets genotyped on the Immunochip identified 15 new susceptibility loci, increasing to 36 the number associated with psoriasis in European individuals, and identified five independent signals within previously known loci.
Journal ArticleDOI
Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk
Helen R. Warren,Evangelos Evangelou,Evangelos Evangelou,Claudia P. Cabrera,He Gao,Meixia Ren,Meixia Ren,Borbala Mifsud,Ioanna Ntalla,Praveen Surendran,Chunyu Liu,James P. Cook,Aldi T. Kraja,Fotios Drenos,Fotios Drenos,Marie Loh,Marie Loh,Niek Verweij,Niek Verweij,Jonathan Marten,Ibrahim Karaman,Marcelo P. Segura Lepe,Marcelo P. Segura Lepe,Paul F. O'Reilly,Joanne Knight,Harold Snieder,Norihiro Kato,Jiang He,E. Shyong Tai,M. Abdullah Said,David J. Porteous,Maris Alver,Neil Poulter,Martin Farrall,Ron T. Gansevoort,Sandosh Padmanabhan,Reedik Mägi,Alice Stanton,John M. C. Connell,Stephan J. L. Bakker,Andres Metspalu,Denis C. Shields,Simon Thom,Morris Brown,Peter S. Sever,Tõnu Esko,Tõnu Esko,Caroline Hayward,Pim van der Harst,Danish Saleheen,Danish Saleheen,Rajiv Chowdhury,John C. Chambers,Daniel I. Chasman,Aravinda Chakravarti,Christopher Newton-Cheh,Christopher Newton-Cheh,Cecilia M. Lindgren,Daniel Levy,Jaspal S. Kooner,Jaspal S. Kooner,Jaspal S. Kooner,Bernard Keavney,Bernard Keavney,Maciej Tomaszewski,Maciej Tomaszewski,Nilesh J. Samani,Nilesh J. Samani,Joanna M. M. Howson,Martin D. Tobin,Patricia B. Munroe,Patricia B. Munroe,Georg Ehret,Georg Ehret,Louise V. Wain +74 more
TL;DR: In this paper, the authors report genetic association of blood pressure (systolic, diastolic, pulse pressure) among UK Biobank participants of European ancestry with independent replication in other cohorts, and robust validation of 107 independent loci.
Journal ArticleDOI
Novel Loci for Adiponectin Levels and Their Influence on Type 2 Diabetes and Metabolic Traits: A Multi-Ethnic Meta-Analysis of 45,891 Individuals
Zari Dastani,Hivert M-F.,Hivert M-F.,N J Timpson,Perry Jrb.,Perry Jrb.,Xin Yuan,Robert A. Scott,Peter Henneman,Iris M. Heid,Jorge R. Kizer,Lyytikäinen L-P.,Christian Fuchsberger,Toshiko Tanaka,Toshiko Tanaka,Andrew P. Morris,Kerrin S. Small,Kerrin S. Small,Aaron Isaacs,Marian Beekman,Stefan Coassin,Kurt Lohman,Lu Qi,Stavroula Kanoni,Stavroula Kanoni,James S. Pankow,Uh H-W.,Ying Wu,Aurelian Bidulescu,Laura J. Rasmussen-Torvik,Greenwood Cmt.,Martin Ladouceur,Jonna L. Grimsby,Alisa K. Manning,Liu C-T.,Jaspal S. Kooner,Vincent Mooser,Peter Vollenweider,Karen Kapur,John C. Chambers,Nicholas J. Wareham,Claudia Langenberg,Rune R. Frants,K Willems-Vandijk,Ben A. Oostra,Sara M. Willems,Claudia Lamina,Thomas W. Winkler,Bruce M. Psaty,Bruce M. Psaty,Russel Tracy,Jennifer A. Brody,I Chen,J. Viikari,Mika Kähönen,Peter P. Pramstaller,David M. Evans,B. St Pourcain,Naveed Sattar,Andrew R. Wood,Stefania Bandinelli,Olga D. Carlson,Josephine M. Egan,Stefan Böhringer,D. van Heemst,Lyudmyla Kedenko,Kati Kristiansson,Nuotio M-L.,Loo B-M.,T.B. Harris,Melissa Garcia,Alka M. Kanaya,Margot Haun,Norman Klopp,Wichmann H-E.,Panos Deloukas,Panos Deloukas,E Katsareli,David Couper,Bruce Bartholow Duncan,Bruce Bartholow Duncan,M. Kloppenburg,Linda S. Adair,Judith B. Borja,James G. Wilson,Solomon K. Musani,Xiuqing Guo,Toby Johnson,Toby Johnson,Toby Johnson,Robert K. Semple,Tanya M. Teslovich,Tanya M. Teslovich,Matthew A. Allison,Susan Redline,Sarah G. Buxbaum,Karen L. Mohlke,Ingrid Meulenbelt,Christie M. Ballantyne,George Dedoussis,Frank B. Hu,Yongmei Liu,Bernhard Paulweber,Tim D. Spector,P E Slagboom,Luigi Ferrucci,Antti Jula,Markus Perola,Olli T. Raitakari,Jose C. Florez,Jose C. Florez,Jose C. Florez,Veikko Salomaa,Johan G. Eriksson,Timothy M. Frayling,Andrew A. Hicks,Terho Lehtimäki,George Davey Smith,David S. Siscovick,Florian Kronenberg,C.M. van Duijn,C.M. van Duijn,Loos Rjf.,Loos Rjf.,Dawn M. Waterworth,James B. Meigs,Josée Dupuis,Josée Dupuis,J B Richards,Benjamin F. Voight,Benjamin F. Voight,Benjamin F. Voight,Laura J. Scott,Valgerdur Steinthorsdottir,Christian Dina,Ryan P. Welch,Eleftheria Zeggini,Eleftheria Zeggini,Cornelia Huth,Yurii S. Aulchenko,Gudmar Thorleifsson,Laura J. McCulloch,Teresa Ferreira,Harald Grallert,Najaf Amin,G Wu,Cristen J. Willer,Soumya Raychaudhuri,Soumya Raychaudhuri,Steven A. McCarroll,Oliver Hofmann,Ayellet V. Segrè,Ayellet V. Segrè,M. van Hoek,M. van Hoek,Pau Navarro,Kristin G. Ardlie,Beverley Balkau,Beverley Balkau,Rafn Benediktsson,Amanda J. Bennett,Roza Blagieva,Eric Boerwinkle,Lori L. Bonnycastle,K B Boström,Bert Bravenboer,S Bumpstead,N P Burtt,Guillaume Charpentier,P S Chines,Marilyn C. Cornelis,G Crawford,G Crawford,Doney Asf.,Katherine S. Elliott,A L Elliott,Michael R. Erdos,Caroline S. Fox,Caroline S. Fox,Christopher S. Franklin,Martha Ganser,Christian Gieger,Niels Grarup,Todd Green,Todd Green,Simon J. Griffin,Christopher J. Groves,Candace Guiducci,Samy Hadjadj,Neelam Hassanali,Christian Herder,Bo Isomaa,Anne U. Jackson,Johnson Prv.,Torben Jørgensen,Kao Whl.,Augustine Kong,Peter Kraft,Johanna Kuusisto,T. Lauritzen,M Li,Aloysius G Lieverse,Cecilia M. Lindgren,Valeriya Lyssenko,Michel Marre,Thomas Meitinger,Kristian Midthjell,Mario A. Morken,Narisu Narisu,Peter M. Nilsson,Katharine R. Owen,Felicity Payne,Petersen A-K.,Carl G. P. Platou,Christine Proença,Inga Prokopenko,Wolfgang Rathmann,Nigel W. Rayner,Neil R. Robertson,Ghislain Rocheleau,Michael Roden,Mike Sampson,Richa Saxena,Richa Saxena,Richa Saxena,B M Shields,Peter Shrader,Gunnar Sigurdsson,Thomas Sparsø,Klaus Strassburger,Heather M. Stringham,Qi Sun,A J Swift,Barbara Thorand,Jean Tichet,Tiinamaija Tuomi,R. M. van Dam,T.W. van Haeften,T van Herpt,J. V. van Vliet-Ostaptchouk,G B Walters,Michael N. Weedon,Cisca Wijmenga,Jacqueline C. M. Witteman,Richard N. Bergman,Stéphane Cauchi,Francis S. Collins,Anna L. Gloyn,Ulf Gyllensten,Torben Hansen,Torben Hansen,Torben Hansen,Winston Hide,Graham A. Hitman,Albert Hofman,David J. Hunter,Kristian Hveem,Markku Laakso,A D Morris,Palmer Cna.,Palmer Cna.,Igor Rudan,Igor Rudan,Igor Rudan,Eric J.G. Sijbrands,Lincoln D. Stein,Jaakko Tuomilehto,A Uitterlinden,Mark Walker,Richard M. Watanabe,Gonçalo R. Abecasis,Bernhard O. Boehm,Harry Campbell,Mark J. Daly,Mark J. Daly,Mark J. Daly,Andrew T. Hattersley,Oluf Pedersen,Oluf Pedersen,Oluf Pedersen,Inês Barroso,L Groop,Robert Sladek,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,J.F. Wilson,Thomas Illig,Philippe Froguel,Philippe Froguel,C M van Duijn,Kari Stefansson,David Altshuler,Michael Boehnke,Mark I. McCarthy,Nicole Soranzo,Nicole Soranzo,Eleanor Wheeler,Nicole L. Glazer,Nabila Bouatia-Naji,Reedik Mägi,Joshua C. Randall,Paul Elliott,Paul Elliott,Denis Rybin,Abbas Dehghan,Jouke-Jan Hottenga,Kijoung Song,Anuj Goel,Taina K. Lajunen,Alex S. F. Doney,Christine Cavalcanti-Proença,Meena Kumari,N J Timpson,Carina Zabena,Erik Ingelsson,Erik Ingelsson,Ping An,Jeffrey R. O'Connell,Jian'an Luan,A Elliott,Rosa Maria Roccasecca,François Pattou,Praveen Sethupathy,Yavuz Ariyurek,Philip J. Barter,John Beilby,Yoav Ben-Shlomo,Sven Bergmann,Sven Bergmann,Murielle Bochud,Amélie Bonnefond,Knut Borch-Johnsen,Knut Borch-Johnsen,Yvonne Böttcher,Eric J. Brunner,S J Bumpstead,Chen Y-Di.,P Chines,Robert Clarke,Coin Ljm.,Mark E. Cooper,Laura Crisponi,Day Inm.,de Geus Ejc.,Jérôme Delplanque,A C Fedson,Antje Fischer-Rosinsky,Nita G. Forouhi,MariaGrazia Franzosi,Pilar Galan,Mark O. Goodarzi,J. Graessler,Scott M. Grundy,R. Gwilliam,Göran Hallmans,Naomi Hammond,Xijing Han,Hartikainen A-L.,Caroline Hayward,S C Heath,Serge Hercberg,David R. Hillman,Aroon D. Hingorani,Jennie Hui,Joseph Hung,Joseph Hung,Marika Kaakinen,Jaakko Kaprio,Jaakko Kaprio,Y A Kesaniemi,Mika Kivimäki,Beatrice Knight,Seppo Koskinen,Peter Kovacs,K O Kyvik,G M Lathrop,Debbie A Lawlor,O Le Bacquer,Cécile Lecoeur,Yun Li,Robert W. Mahley,Massimo Mangino,María Teresa Martínez-Larrad,Jarred B. McAteer,Jarred B. McAteer,Ruth McPherson,Christa Meisinger,David Melzer,David Meyre,Braxton D. Mitchell,Sutapa Mukherjee,Silvia Naitza,Matt Neville,Marco Orrù,Ruth E. Pakyz,Giuseppe Paolisso,Cristian Pattaro,Daniel S. Pearson,J F Peden,Nancy L. Pedersen,Pfeiffer Afh.,Irene Pichler,Ozren Polasek,Danielle Posthuma,Simon C. Potter,A Pouta,M. A. Province,Kenneth Rice,Samuli Ripatti,Samuli Ripatti,Fernando Rivadeneira,Olov Rolandsson,A. Sandbaek,M Sandhu,Serena Sanna,Avan Aihie Sayer,Paul Scheet,Udo Seedorf,Stephen J. Sharp,B Shields,Gunnar Sigurðsson,Sijbrands Ejg.,Sijbrands Ejg.,Angela Silveira,Laila Simpson,Andrew B. Singleton,Nicholas L. Smith,Nicholas L. Smith,Ulla Sovio,A Swift,Holly E. Syddall,Syvänen A-C.,Anke Tönjes,A G Uitterlinden,K W van Dijk,K W van Dijk,Dhiraj Varma,Sophie Visvikis-Siest,Veronique Vitart,N Vogelzangs,N Vogelzangs,Gerard Waeber,P J Wagner,P J Wagner,P J Wagner,Andrew Walley,Kim L. Ward,Hugh Watkins,Sarah H. Wild,Gonneke Willemsen,Witteman Jcm.,Yarnell Jwg.,Diana Zelenika,Björn Zethelius,Björn Zethelius,Guangju Zhai,Jing Hua Zhao,M C Zillikens,M C Zillikens,Ingrid B. Borecki,Pierre Meneton,Magnusson Pke.,David M. Nathan,Gordon H. Williams,Kaisa Silander,Kaisa Silander,Stefan R. Bornstein,Peter Schwarz,Jochen Spranger,Fredrik Karpe,Alan R. Shuldiner,Cyrus Cooper,Manuel Serrano-Ríos,Lars Lind,Lyle J. Palmer,Lyle J. Palmer,Paul W. Franks,Shah Ebrahim,Michael Marmot,Alan F. Wright,Michael Stumvoll,Anders Hamsten,Anders Hamsten,Thomas A. Buchanan,Timo T. Valle,Jerome I. Rotter,Penninx Bwjh.,Penninx Bwjh.,Dorret I. Boomsma,Dorret I. Boomsma,Anyuan Cao,Angelo Scuteri,Angelo Scuteri,David Schlessinger,Manuela Uda,Aimo Ruokonen,Jarvelin M-R.,Leena Peltonen,V Mooser,Kiran Musunuru,Kiran Musunuru,Albert V. Smith,Andrew C. Edmondson,Ioannis M. Stylianou,Masahiro Koseki,James P. Pirruccello,James P. Pirruccello,James P. Pirruccello,Daniel I. Chasman,Christopher T. Johansen,Sigrid W. Fouchier,Gina M. Peloso,Gina M. Peloso,Maja Barbalić,Sally L. Ricketts,J. C. Bis,Mary F. Feitosa,Marju Orho-Melander,Olle Melander,Xiaohui Li,Yoon Shin Cho,Min Jin Go,Young-Jin Kim,Lee J-Y.,Taesung Park,K Kim,Xueling Sim,Ong Rt-H.,Damien C. Croteau-Chonka,Leslie A. Lange,Josh Smith,Andreas Ziegler,Weihua Zhang,Zee Ryl.,John Whitfield,John R. Thompson,Ida Surakka,Ida Surakka,J.H. Smit,Juha Sinisalo,Jan Scott,Juha Saharinen,Chiara Sabatti,Lynda M. Rose,Robert Roberts,Mark J. Rieder,Alex N. Parker,Guillaume Paré,Christopher J. O'Donnell,Christopher J. O'Donnell,Markku S. Nieminen,Deborah A. Nickerson,Grant W. Montgomery,Wendy L. McArdle,David Masson,Nicholas G. Martin,Fabio Marroni,Gavin Lucas,Robert Luben,Lokki M-L.,Guillaume Lettre,Lenore J. Launer,Edward G. Lakatta,Reijo Laaksonen,Inke R. König,Khaw K-T.,Lee M. Kaplan,Åsa Johansson,Janssens Acjw.,Wilmar Igl,G K Hovingh,Christian Hengstenberg,Aki S. Havulinna,Aki S. Havulinna,Nicholas D. Hastie,T B Harris,Talin Haritunians,Alyson Hall,L C Groop,Elena Gonzalez,Nelson B. Freimer,Jeanette Erdmann,Kenechi Ejebe,Angela Döring,Anna F. Dominiczak,Serkalem Demissie,Serkalem Demissie,U de Faire,Mark J. Caulfield,S.M. Boekholdt,Themistocles L. Assimes,Thomas Quertermous,Mark Seielstad,Tien Yin Wong,Tai E-S.,Alan B. Feranil,Christopher W. Kuzawa,Herman A. Taylor,S. Gabriel,Hilma Holm,Vilmundur Gudnason,Ronald M. Krauss,Jose M. Ordovas,Jose M. Ordovas,Patricia B. Munroe,J S Kooner,Alan R. Tall,Robert A. Hegele,Kastelein Jjp.,Eric E. Schadt,David P. Strachan,Muredach P. Reilly,Nilesh J. Samani,Heribert Schunkert,L A Cupples,M S Sandhu,Paul M. Ridker,Daniel J. Rader,Sekar Kathiresan +618 more
TL;DR: A meta-analysis of genome-wide association studies in 39,883 individuals of European ancestry to identify genes associated with metabolic disease identifies novel genetic determinants of adiponectin levels, which, taken together, influence risk of T2D and markers of insulin resistance.
Journal ArticleDOI
Genome-wide Association Study Identifies Genes for Biomarkers of Cardiovascular Disease: Serum Urate and Dyslipidemia
Chris Wallace,Stephen Newhouse,Peter S. Braund,Feng Zhang,Martin D. Tobin,Mario Falchi,Kourosh R. Ahmadi,Richard Dobson,Ana Carolina B. Marçano,Cother Hajat,Paul Burton,Panagiotis Deloukas,Morris J. Brown,John M. C. Connell,Anna F. Dominiczak,G. Mark Lathrop,John Webster,Martin Farrall,Tim D. Spector,Nilesh J. Samani,Mark J. Caulfield,Patricia B. Munroe +21 more
TL;DR: A genome-wide association analysis for commonly measured serum and urine biochemical traits found association between serum urate and SLC2A9, a glucose transporter, and provides a potential biological mechanism for the recent association of this same allele of the same SNP with increased risk of coronary disease.
Journal ArticleDOI
A meta-analysis of the association of the deletion allele of the angiotensin-converting enzyme gene with myocardial infarction.
TL;DR: A meta-analysis of published studies supports an association of the ACE D allele with MI risk and strengthens the justification for further evaluation in appropriately powered studies.