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Nilesh J. Samani
Researcher at University of Leicester
Publications - 836
Citations - 127518
Nilesh J. Samani is an academic researcher from University of Leicester. The author has contributed to research in topics: Genome-wide association study & Population. The author has an hindex of 149, co-authored 779 publications receiving 113545 citations. Previous affiliations of Nilesh J. Samani include University Hospitals of Leicester NHS Trust & Glenfield Hospital.
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Genetic and modifiable risk factors combine multiplicatively in common disease
Shichao Pang,Loic Yengo,Christopher P. Nelson,Felix Bourier,Lingyao Zeng,Lin Li,Thorsten Kessler,Jeanette Erdmann,Reedik Mägi,Kristi Läll,Andres Metspalu,Bertram Mueller-Myhsok,Nilesh J. Samani,Peter M. Visscher,Heribert Schunkert +14 more
TL;DR: In this paper , the cumulative effects of common risk alleles and their prevalence variations with classical risk factors were analyzed mathematically and statistically for coronary artery disease (CAD) and other conditions, and the authors suggest that the biological systems underlying these diseases are modulated by hundreds of genes but become only fragile when a narrow window of total risk, irrespective of its genetic or environmental origins, has been passed.
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Pleiotropic molecular targets of coxibs reveals novel genomic loci conferring coronary artery disease risk
Ingrid Braenne,Christina Willenborg,Benedikt Reiz,Lingyao Zeng,Thomas Meitinger,Nilesh J. Samani,Thorsten Kessler,Folkert W. Asselbergs,J. Erdmann,Heribert Schunkert +9 more
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Mechanism and clinical significance of precordial ST depression in inferior myocardial infarction: evaluation by contrast-enhanced dynamic myocardial perfusion magnetic resonance imaging.
James H. S. Cullen,Graham R. Cherryman,Nilesh J. Samani,J. Tranter,Asvina Jivan,Mark A. Horsfield,K. L. Woods,David B. Barnett +7 more
TL;DR: MRI shows that precordial ST depression in inferior myocardial infarction is a marker for a larger global perfusion abnormality with posterolateral basal extension and an increase in adverse clinical end points, highlighting the potential of MRI perfusion studies as a research and clinical tool in myocardia infarct.
Journal Article
Abstract 19822: Ldlr Splice-Site Mutation (ivs9-1g>A) Identified by Whole-Exome Sequencing in an Extended Family with Myocardial Infarction
Ingrid Braenne,Anja Medack,Klaus Stark,Sarah Field,Salih Tuna,Panos Deloukas,Nilesh J. Samani,Heribert Schunkert,Christian Hengstenberg,Jeanette Erdmann +9 more