N
Nilesh J. Samani
Researcher at University of Leicester
Publications - 836
Citations - 127518
Nilesh J. Samani is an academic researcher from University of Leicester. The author has contributed to research in topics: Genome-wide association study & Population. The author has an hindex of 149, co-authored 779 publications receiving 113545 citations. Previous affiliations of Nilesh J. Samani include University Hospitals of Leicester NHS Trust & Glenfield Hospital.
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Journal ArticleDOI
Circulating plasma concentrations of angiotensin-converting enzyme 2 in men and women with heart failure and effects of renin-angiotensin-aldosterone inhibitors.
Iziah E Sama,Alice Ravera,Alice Ravera,Bernadet T. Santema,Harry van Goor,Jozine M. ter Maaten,John G.F. Cleland,Michiel Rienstra,Alexander W. Friedrich,Nilesh J. Samani,Leong L. Ng,Kenneth Dickstein,Kenneth Dickstein,Chim C. Lang,Gerasimos Filippatos,Gerasimos Filippatos,Stefan D. Anker,Piotr Ponikowski,Marco Metra,Dirk J. van Veldhuisen,Adriaan A. Voors +20 more
TL;DR: In this article, the authors measured ACE2 concentrations in 1485 men and 537 women with heart failure (index cohort) and found that the strongest predictor of elevated concentrations of ACE2 in both cohorts was male sex.
Journal ArticleDOI
MicroRNAs in cardiovascular disease: an introduction for clinicians
Simon P. R. Romaine,Maciej Tomaszewski,Gianluigi Condorelli,Gianluigi Condorelli,Nilesh J. Samani +4 more
TL;DR: There is potential for miRNAs to complement existing risk prediction models and act as valuable markers of post-AMI prognosis, and promising preclinical studies suggest that they could be useful in treating disorders ranging from heart failure to dyslipidaemia, although several challenges related to specificity and targeted delivery remain to be overcome.
Journal ArticleDOI
Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure
Louise V. Wain,Germaine C. Verwoert,Paul F. O'Reilly,Gang Shi,Toby Johnson,Andrew D. Johnson,Murielle Bochud,Kenneth Rice,Peter Henneman,Albert V. Smith,Georg Ehret,Georg Ehret,Georg Ehret,Najaf Amin,Martin G. Larson,Martin G. Larson,Vincent Mooser,David Hadley,David Hadley,Marcus Doerr,Joshua C. Bis,Thor Aspelund,Tõnu Esko,A. Cecile J.W. Janssens,Jing Hua Zhao,Simon Heath,Maris Laan,Jingyuan Fu,Giorgio Pistis,Jian'an Luan,Pankaj Arora,Gavin Lucas,Nicola Pirastu,Irene Pichler,Anne U. Jackson,Rebecca J. Webster,Feng Zhang,John F. Peden,Helena Schmidt,Toshiko Tanaka,Harry Campbell,Wilmar Igl,Yuri Milaneschi,Jouke-Jan Hottenga,Veronique Vitart,Daniel I. Chasman,Stella Trompet,Jennifer L. Bragg-Gresham,Behrooz Z. Alizadeh,John C. Chambers,John C. Chambers,Xiuqing Guo,Terho Lehtimäki,Brigitte Kuehnel,Lorna M. Lopez,Ozren Polasek,Mladen Boban,Christopher P. Nelson,Alanna C. Morrison,Vasyl Pihur,Santhi K. Ganesh,Albert Hofman,Suman Kundu,Francesco U.S. Mattace-Raso,Fernando Rivadeneira,Eric J.G. Sijbrands,André G. Uitterlinden,Shih-Jen Hwang,Ramachandran S. Vasan,Thomas J. Wang,Sven Bergmann,Peter Vollenweider,Gérard Waeber,Jaana Laitinen,Anneli Pouta,Paavo Zitting,Wendy L. McArdle,Heyo K. Kroemer,Uwe Voelker,Henry Voelzke,Nicole L. Glazer,Kent D. Taylor,Tamara B. Harris,Helene Alavere,Toomas Haller,Aime Keis,Mari-Liis Tammesoo,Yurii S. Aulchenko,Inês Barroso,Kay-Tee Khaw,Pilar Galan,Serge Hercberg,Mark Lathrop,Susana Eyheramendy,Elin Org,Siim Sõber,Xiaowen Lu,Ilja M. Nolte,Brenda W.J.H. Penninx,Tanguy Corre,Corrado Masciullo,Cinzia Sala,Leif Groop,Benjamin F. Voight,Olle Melander,Christopher J. O'Donnell,Veikko Salomaa,Adamo Pio D'Adamo,Antonella Fabretto,Flavio Faletra,Sheila Ulivi,Fabiola M. Del Greco,Maurizio F. Facheris,Francis S. Collins,Richard N. Bergman,John Beilby,Joseph Hung,A. William Musk,Massimo Mangino,So-Youn Shin,Nicole Soranzo,Hugh Watkins,Anuj Goel,Anders Hamsten,Pierre Gider,Marisa Loitfelder,Marion Zeginigg,Dena G. Hernandez,Samer S. Najjar,Pau Navarro,Sarah H. Wild,Anna Maria Corsi,Andrew B. Singleton,Eco J. C. de Geus,Gonneke Willemsen,Alex Parker,Lynda M. Rose,Brendan M. Buckley,David J. Stott,Marco Orru,Manuela Uda,Melanie M. van der Klauw,Weihua Zhang,Xinzhong Li,James Scott,Yii-Der Ida Chen,Gregory L. Burke,Mika Kähönen,Jorma Viikari,Angela Doering,Thomas Meitinger,Gail Davies,John M. Starr,Valur Emilsson,Andrew S. Plump,Jan H.N. Lindeman,Peter A C 't Hoen,Inke R. Koenig,Janine F. Felix,Robert Clarke,Jemma C. Hopewell,Halit Ongen,Monique M.B. Breteler,Stéphanie Debette,Anita L. DeStefano,Myriam Fornage,Gary F. Mitchell,Nicholas L. Smith,Hilma Holm,Kari Stefansson,Gudmar Thorleifsson,Unnur Thorsteinsdottir,Nilesh J. Samani,Michael Preuss,Igor Rudan,Caroline Hayward,Ian J. Deary,H-Erich Wichmann,Olli T. Raitakari,Walter Palmas,Jaspal S. Kooner,Jaspal S. Kooner,Ronald P. Stolk,J. Wouter Jukema,Alan F. Wright,Dorret I. Boomsma,Stefania Bandinelli,Ulf Gyllensten,James F. Wilson,Luigi Ferrucci,Reinhold Schmidt,Martin Farrall,Tim D. Spector,Lyle J. Palmer,Jaakko Tuomilehto,Arne Pfeufer,Paolo Gasparini,David S. Siscovick,David Altshuler,Ruth J. F. Loos,Daniela Toniolo,Harold Snieder,Christian Gieger,Pierre Meneton,Nicholas J. Wareham,Ben A. Oostra,Andres Metspalu,Lenore J. Launer,Rainer Rettig,David P. Strachan,Jacques S. Beckmann,Jacqueline C. M. Witteman,Jeanette Erdmann,Ko Willems van Dijk,Eric Boerwinkle,Michael Boehnke,Paul M. Ridker,Marjo-Riitta Järvelin,Aravinda Chakravarti,Gonçalo R. Abecasis,Vilmundur Gudnason,Christopher Newton-Cheh,Daniel Levy,Patricia B. Munroe,Bruce M. Psaty,Mark J. Caulfield,Dabeeru C. Rao,Martin D. Tobin,Paul Elliott,Cornelia M. van Duijn +229 more
TL;DR: Findings suggest new genetic pathways underlying blood pressure variation, some of which may differentially influence SBP and DBP, as well as two new MAP loci associated with both of these traits.
Journal ArticleDOI
Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes.
Kaixin Zhou,Kaixin Zhou,Céline Bellenguez,Chris C. A. Spencer,Amanda J. Bennett,Ruth L. Coleman,Ruth L. Coleman,Roger Tavendale,Roger Tavendale,Simon A. Hawley,Louise A. Donnelly,Louise A. Donnelly,Christopher Schofield,Christopher Schofield,Christopher J. Groves,Christopher J. Groves,Lindsay Burch,Lindsay Burch,Fiona Carr,Fiona Carr,Amy Strange,Colin Freeman,Jenefer M. Blackwell,Elvira Bramon,Elvira Bramon,Matthew A. Brown,Matthew A. Brown,Juan P. Casas,Juan P. Casas,Aiden Corvin,N. Craddock,Panos Deloukas,Panos Deloukas,Serge Dronov,Serge Dronov,A. Duncanson,Sarah Edkins,Sarah Edkins,Emma Gray,Emma Gray,Sarah E. Hunt,Sarah E. Hunt,Joachim Jankowski,Joachim Jankowski,Joachim Jankowski,Cordelia Langford,Cordelia Langford,Hugh S. Markus,Christopher G. Mathew,Robert Plomin,Anna Rautanen,Stephen Sawcer,Nilesh J. Samani,Nilesh J. Samani,Nilesh J. Samani,Richard C. Trembath,Ananth C. Viswanathan,Nicholas W. Wood,Lorna W. Harries,Lorna W. Harries,Andrew T. Hattersley,Andrew T. Hattersley,Alex S. F. Doney,Alex S. F. Doney,Helen M. Colhoun,Andrew D. Morris,Calum Sutherland,Calum Sutherland,D. G. Hardie,D. G. Hardie,Leena Peltonen,Mark I. McCarthy,Rury R. Holman,Colin N. A. Palmer,Colin N. A. Palmer,Peter Donnelly,Ewan R. Pearson +76 more
TL;DR: It is concluded that ATM, a gene known to be involved in DNA repair and cell cycle control, plays a role in the effect of metformin upstream of AMP-activated protein kinase, and variation in this gene alters glycemic response to meetformin.
Journal ArticleDOI
Meta-analysis of telomere length in 19 713 subjects reveals high heritability, stronger maternal inheritance and a paternal age effect
Linda Broer,Veryan Codd,Veryan Codd,Dale R. Nyholt,Joris Deelen,Massimo Mangino,Gonneke Willemsen,Eva Albrecht,Najaf Amin,Marian Beekman,Eco J. C. de Geus,Anjali K. Henders,Christopher P. Nelson,Claire J. Steves,Margie Wright,Anton J. M. de Craen,Aaron Isaacs,Mary K. Matthews,Alireza Moayyeri,Grant W. Montgomery,Ben A. Oostra,Jacqueline M. Vink,Tim D. Spector,P. Eline Slagboom,Nicholas G. Martin,Nilesh J. Samani,Cornelia M. van Duijn,Cornelia M. van Duijn,Dorret I. Boomsma +28 more
TL;DR: A high and very consistent heritability estimate for TL is found, evidence for a maternal inheritance component and the influence of parental age at birth on TL is investigated, and a positive association with paternal age is found.