N
Nilesh J. Samani
Researcher at University of Leicester
Publications - 836
Citations - 127518
Nilesh J. Samani is an academic researcher from University of Leicester. The author has contributed to research in topics: Genome-wide association study & Population. The author has an hindex of 149, co-authored 779 publications receiving 113545 citations. Previous affiliations of Nilesh J. Samani include University Hospitals of Leicester NHS Trust & Glenfield Hospital.
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Journal ArticleDOI
Identifying Pathophysiological Mechanisms in Heart Failure With Reduced Versus Preserved Ejection Fraction
Jasper Tromp,B. Daan Westenbrink,Wouter Ouwerkerk,Dirk J. van Veldhuisen,Nilesh J. Samani,Piotr Ponikowski,Marco Metra,Stefan D. Anker,John G.F. Cleland,Kenneth Dickstein,Gerasimos Filippatos,Pim van der Harst,Chim C. Lang,Leong L. Ng,Faiez Zannad,A. H. Zwinderman,Hans L. Hillege,Peter van der Meer,Adriaan A. Voors +18 more
TL;DR: Network analysis showed that biomarker profiles specific for HFrEF are related to cellular proliferation and metabolism, whereas biomarkers specific for HFpEF arerelated to inflammation and extracellular matrix reorganization.
Journal ArticleDOI
A Genome-Wide Association Study Reveals Variants in ARL15 that Influence Adiponectin Levels
J. Brent Richards,J. Brent Richards,Dawn M. Waterworth,Stephen O'Rahilly,Marie-France Hivert,Ruth J. F. Loos,John R. B. Perry,Toshiko Tanaka,Nicholas J. Timpson,Robert K. Semple,Nicole Soranzo,Nicole Soranzo,Kijoung Song,Nuno Rocha,Elin Grundberg,Josée Dupuis,Jose C. Florez,Jose C. Florez,Claudia Langenberg,Inga Prokopenko,Richa Saxena,Richa Saxena,Robert Sladek,Yurii S. Aulchenko,David M. Evans,Gérard Waeber,Jeanette Erdmann,Mary-Susan Burnett,Naveed Sattar,Joseph M. Devaney,Christina Willenborg,Aroon D. Hingorani,Jaquelin C. M. Witteman,Peter Vollenweider,Beate Glaser,Christian Hengstenberg,Luigi Ferrucci,David Melzer,Klaus Stark,John E. Deanfield,Janina Winogradow,Martina Grassl,Alistair S. Hall,Josephine M. Egan,John R. Thompson,Sally L. Ricketts,Inke R. König,Wibke Reinhard,Scott M. Grundy,H-Erich Wichmann,Phil Barter,Robert W. Mahley,Y. Antero Kesäniemi,Daniel J. Rader,Muredach P. Reilly,Stephen E. Epstein,Alexandre F.R. Stewart,Cornelia M. van Duijn,Heribert Schunkert,Keith Burling,Panos Deloukas,Tomi Pastinen,Nilesh J. Samani,Ruth McPherson,George Davey Smith,Timothy M. Frayling,Nicholas J. Wareham,James B. Meigs,Vincent Mooser,Tim D. Spector +69 more
TL;DR: A novel protein is identified, ARL15, which influences circulating adiponectin levels and may impact upon CHD risk, and several metabolic traits are identified.
Journal ArticleDOI
Large Scale association analysis of novel genetic loci for coronary artery disease
Nilesh J. Samani,Panagiotis Deloukas,J Erdmann,Christian Hengstenberg,Kari Kuulasmaa,Ralph McGinnis,Heribert Schunkert,Nicole Soranzo,John R. Thompson,Laurence Tiret,Andreas Ziegler +10 more
TL;DR: In this article, the authors conducted association analysis of single nucleotide polymorphisms at each locus with CAD risk in 11 550 cases and 11 205 controls from 9 European studies and found strong evidence for association between at least 4 genetic loci and CAD risk.
Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension
Praveen Surendran,Fotios Drenos,Robin Young,Helen R. Warren,James P. Cook,Alisa K. Manning,Niels Grarup,Xueling Sim,Daniel R. Barnes,Kate Witkowska,James R Staley,Vinicius Tragante,Taru Tukiainen,Hanieh Yaghootkar,Nicholas G. D. Masca,Daniel F. Freitag,Teresa Ferreira,Olga Giannakopoulou,Andrew Tinker,Magdalena Harakalova,Evelin Mihailov,Chunyu Liu,Aldi T. Kraja,Sune F. Nielsen,Asif Rasheed,Maria Samue,Wei Zhao,Lori L. Bonnycastle,Anne U. Jackson,Narisu Narisu,Amy J. Swift,Lorraine Southam,Jonathan Marten,Jeroen R. Huyghe,Alena Stančáková,Cristiano Fava,Therese Ohlsson,Angela Matchan,Kathleen Stirrups,Jette Bork-Jensen,Anette P. Gjesing,Jukka Kontto,Markus Perola,Susan Shaw-Hawkins,Aki S. Havulinna,He Zhang,Louise A. Donnelly,Christopher J. Groves,N. William Rayner,Matt Neville,Neil R. Robertson,Andrianos M. Yiorkas,Karl-Heinz Herzig,Eero Kajantie,Weihua Zhang,Sara M. Willems,Lars Lannfelt,Giovanni Malerba,Nicole Soranzo,Elisabetta Trabetti,Niek Verweij,Evangelos Evangelou,Alireza Moayyeri,Anne-Claire Vergnaud,Christopher P. Nelson,Alaitz Poveda,Tibor V. Varga,Muriel J. Caslake,Anton J. M. de Craen,Stella Trompet,Jian'an Luan,Robert A. Scott,Sarah E. Harris,David C. Liewald,Riccardo E. Marioni,Cristina Menni,Aliki-Eleni Farmaki,Göran Hallmans,Frida Renström,Jennifer E. Huffman,Maija Hassinen,Stephen Burgess,Ramachandran S. Vasan,Janine F. Felix,Maria Uria-Nickelsen,Anders Malarstign,Dermot F. Reilly,Maarten Hoek,Thomas F. Vogt,Honghuang Lin,Wolfgang Lieb,Matthew Traylor,Hugh S. Markus,Heather M. Highland,Anne E. Justice,Eirini Marouli,Jaana Lindström,Matti Uusitupa,Pirjo Komulainen,Timo A. Lakka,Rainer Rauramaa,Ozren Polasek,Igor Rudan,Olov Rolandsson,Paul W. Franks,George Dedoussis,Tim D. Spector,Pekka Jousilahti,Satu Männistö,Ian J. Deary,John M. Starr,Claudia Langenberg,Nicholas J. Wareham,Morris Brown,Anna F. Dominiczak,John M. C. Connell,J. Wouter Jukema,Naveed Sattar,Ian Ford,Chris J. Packard,Tõnu Esko,Reedik Mägi,Andres Metspalu,Rudolf A. de Boer,Peter van der Meer,Pim van der Harst,Giovanni Gambaro,Erik Ingelsson,Lars Lind,Paul I.W. de Bakker,Mattijs E. Numans,Ivan Brandslund,Cramer Christensen,Eva Rabing Brix Petersen,Eeva Korpi-Hyövälti,Heikki Oksa,John C. Chambers,Jaspal S. Kooner,Alexandra I. F. Blakemore,Steve Franks,Marjo-Riitta Järvelin,Lise Lotte N. Husemoen,Allan Linneberg,Tea Skaaby,Betina H. Thuesen,Fredrik Karpe,Jaakko Tuomilehto,Alex S. F. Doney,Andrew D. Morris,Colin N. A. Palmer,Oddgeir L. Holmen,Kristian Hveem,Cristen J. Willer,Tiinamaija Tuomi,Leif Groop,Annemari Käräjämäki,Aarno Palotie,Samuli Ripatti,Veikko Salomaa,Dewan S. Alam,Abdulla Al Shafi Majmnder,Emanuele Di Angelantonio,Rajiv Chowdhury,Mark I. McCarthy,Neil Poulter,Alice Stanton,Peter S. Sever,Philippe Amouyel,Dominique Arveiler,Stefan Blankenberg,Jean Ferrières,Frank Kee,Kari Kuulasmaa,Martina Müller-Nurasyid,Giovanni Veronesi,Jarmo Virtamo,Panos Deloukas,Paul Elliott,Eleftheria Zeggini,Sekar Kathiresan,Olle Melander,Johanna Kuusisto,Markku Laakso,Sandosh Padmanabhan,David J. Porteous,Caroline Hayward,Generation Scotland,Francis S. Collins,Karen L. Mohlke,Torben Hansen,Oluf Pedersen,Michael Boehnke,Heather M. Stringham,Philippe M. Frossard,Christopher Newton-Cheh,Martin D. Tobin,Børge G. Nordestgaard,Mark J. Caulfield,Anubha Mahajan,Andrew P. Morris,Maciej Tomaszewski,Nilesh J. Samani,Danish Saleheen,Folkert W. Asselbergs,Cecilia M. Lindgren,John Danesh,Louise V. Wain,Adam S. Butterworth,Joanna M. M. Howson,Patricia B. Munroe +209 more
Journal ArticleDOI
Common genetic loci influencing plasma homocysteine concentrations and their effect on risk of coronary artery disease
Joyce B. J. van Meurs,Guillaume Paré,Stephen M. Schwartz,Aditi Hazra,Toshiko Tanaka,Sita H. Vermeulen,Ioana Cotlarciuc,Xin Yuan,Anders Mälarstig,Stefania Bandinelli,Joshua C. Bis,Henk J. Blom,Morris J. Brown,Constance Chen,Yii Der Chen,Robert Clarke,Abbas Dehghan,Jeanette Erdmann,Luigi Ferrucci,Anders Hamsten,Albert Hofman,David J. Hunter,Anuj Goel,Andrew D. Johnson,Sekar Kathiresan,Ellen Kampman,Douglas P. Kiel,Lambertus A. Kiemeney,John C. Chambers,Peter Kraft,Jan Lindemans,Barbara McKnight,Christopher P. Nelson,Christopher J. O'Donnell,Bruce M. Psaty,Paul M. Ridker,Fernando Rivadeneira,Lynda M. Rose,Udo Seedorf,David S. Siscovick,Heribert Schunkert,Jacob Selhub,Per Magne Ueland,Peter Vollenweider,Gérard Waeber,Dawn Waterworth,Hugh Watkins,Jacqueline C.M. Witteman,Martin den Heijer,Paul F. Jacques,André G. Uitterlinden,Jaspal S. Kooner,Daniel J. Rader,Muredach P. Reilly,Vincent Mooser,Daniel I. Chasman,Nilesh J. Samani,Kourosh R. Ahmadi +57 more
TL;DR: Overall, common genetic variants that influence plasma tHcy concentrations are not associated with risk of CAD in white populations, which further refutes the causal relevance of moderately elevated tH Cy concentrations and tHCy-related pathways for CAD.