N
Nilesh J. Samani
Researcher at University of Leicester
Publications - 836
Citations - 127518
Nilesh J. Samani is an academic researcher from University of Leicester. The author has contributed to research in topics: Genome-wide association study & Population. The author has an hindex of 149, co-authored 779 publications receiving 113545 citations. Previous affiliations of Nilesh J. Samani include University Hospitals of Leicester NHS Trust & Glenfield Hospital.
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Journal ArticleDOI
Lifelong reduction of LDL-cholesterol related to a common variant in the LDL-receptor gene decreases the risk of coronary artery disease--a Mendelian Randomisation study.
Patrick Linsel-Nitschke,Anika Götz,Jeanette Erdmann,Ingrid Braenne,Peter S. Braund,Christian Hengstenberg,Klaus Stark,Marcus Fischer,Stefan Schreiber,Nour Eddine El Mokhtari,Arne S. Schaefer,Jürgen Schrezenmeier,Diana Rubin,Anke Hinney,Thomas Reinehr,Christian L. Roth,Christian L. Roth,Jan R. Ortlepp,Peter Hanrath,Alistair S. Hall,Massimo Mangino,Wolfgang Lieb,Claudia Lamina,Iris M. Heid,Angela Doering,Christian Gieger,Annette Peters,Thomas Meitinger,H.-Erich Wichmann,Inke R. König,Andreas Ziegler,Florian Kronenberg,Nilesh J. Samani,Heribert Schunkert +33 more
TL;DR: A functional link is found between the genetic variant at the LDLR gene locus, change in LDL-C and risk of CAD, and, thereby, the risk for CAD.
Journal ArticleDOI
Genomewide Association Study Using a High-Density Single Nucleotide Polymorphism Array and Case-Control Design Identifies a Novel Essential Hypertension Susceptibility Locus in the Promoter Region of Endothelial NO Synthase
Erika Salvi,Zoltán Kutalik,Nicola Glorioso,Paola Benaglio,Francesca Frau,Tatiana Kuznetsova,Hisatomi Arima,Clive J. Hoggart,Jean Tichet,Y Nikitin,Costanza Conti,Jitka Seidlerová,Valérie Tikhonoff,Katarzyna Stolarz-Skrzypek,Toby Johnson,Nabila Devos,Laura Zagato,Simonetta Guarrera,Roberta Zaninello,Andrea Calabria,Benedetta Stancanelli,Chiara Troffa,Lutgarde Thijs,Federica Rizzi,Galina Simonova,Sara Lupoli,Giuseppe Argiolas,Daniele Braga,Maria C. D'Alessio,Maria Francesca Ortu,Fulvio Ricceri,Maurizio Mercurio,Patrick Descombes,Maurizio Marconi,John Chalmers,Stephen B. Harrap,Jan Filipovsky,Murielle Bochud,Licia Iacoviello,Justine A. Ellis,Alice Stanton,Maris Laan,Sandosh Padmanabhan,Anna F. Dominiczak,Nilesh J. Samani,Olle Melander,Xavier Jeunemaitre,Paolo Manunta,Amnon Shabo,Paolo Vineis,Francesco P. Cappuccio,Mark J. Caulfield,Giuseppe Matullo,Carlo Rivolta,Patricia B. Munroe,Cristina Barlassina,Jan A. Staessen,Jacques S. Beckmann,Daniele Cusi +58 more
TL;DR: Biological evidence links endothelial NO synthase with hypertension, because it is a critical mediator of cardiovascular homeostasis and blood pressure control via vascular tone regulation, and the hypothesis that there may be a causal genetic variation at this locus is supported.
Journal ArticleDOI
Apolipoprotein(a) Genetic Sequence Variants Associated With Systemic Atherosclerosis and Coronary Atherosclerotic Burden But Not With Venous Thromboembolism.
Anna Helgadottir,Solveig Gretarsdottir,Gudmar Thorleifsson,Hilma Holm,Riyaz S. Patel,Riyaz S. Patel,Thorarinn Gudnason,Gregory T. Jones,Andre M. van Rij,Danny J. Eapen,Annette F. Baas,David-Alexandre Trégouët,Pierre-Emmanuel Morange,Joseph Emmerich,Bengt Lindblad,Anders Gottsäter,Lambertus A Kiemeny,Jes S. Lindholt,Natzi Sakalihasan,Robert E. Ferrell,David J. Carey,James R. Elmore,Philip S. Tsao,Niels Grarup,Torben Jørgensen,Torben Jørgensen,Daniel R. Witte,Torben Hansen,Torben Hansen,Oluf Pedersen,Roberto Pola,Roberto Pola,Eleonora Gaetani,Hulda B Magnadottir,Cisca Wijmenga,Gerard Tromp,Antti Ronkainen,Ynte M. Ruigrok,Jan D. Blankensteijn,Thomas Mueller,Philip S. Wells,Javier Corral,José Manuel Soria,Juan Carlos Souto,John F. Peden,Shapour Jalilzadeh,Bongani M. Mayosi,Bernard Keavney,Rona J. Strawbridge,Maria Sabater-Lleal,Karl Gertow,Damiano Baldassarre,Kristiina Nyyssönen,Rainer Rauramaa,Andries J. Smit,Elmo Mannarino,Philippe Giral,Elena Tremoli,Ulf de Faire,Steve E. Humphries,Anders Hamsten,Vilhelmina Haraldsdottir,Isleifur Olafsson,Magnus K. Magnusson,Nilesh J. Samani,Allan I. Levey,Hugh S. Markus,Konstantinos Kostulas,Martin Dichgans,Klaus Berger,Gregor Kuhlenbäumer,E. Bernd Ringelstein,Monika Stoll,Udo Seedorf,Peter M. Rothwell,Janet T. Powell,Helena Kuivaniemi,Pall T. Onundarson,Einar M. Valdimarsson,Stefan E Matthiasson,Daniel F. Gudbjartsson,G Thorgeirsson,Arshed A. Quyyumi,Hugh Watkins,Martin Farrall,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Kari Stefansson,Kari Stefansson +88 more
TL;DR: LPA sequence variants were associated with atherosclerotic burden, but not with primarily thrombotic phenotypes, and CAD cases carrying LPA risk variants had increased susceptibility to atherosclerosis manifestations outside of the coronary tree.
Journal ArticleDOI
A systems BIOlogy Study to TAilored Treatment in Chronic Heart Failure : rationale, design, and baseline characteristics of BIOSTAT-CHF
Adriaan A. Voors,Stefan D. Anker,John G.F. Cleland,Kenneth Dickstein,Kenneth Dickstein,Gerasimos Filippatos,Pim van der Harst,Hans L. Hillege,Chim C. Lang,Jozine M. ter Maaten,Leong L. Ng,Piotr Ponikowski,Nilesh J. Samani,Dirk J. van Veldhuisen,F. Zannad,Aeilko H. Zwinderman,Marco Metra +16 more
TL;DR: It is hypothesize that individualized therapy is an essential next step to improve outcomes in patients with heart failure.
Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk
Helen R. Warren,Evangelos Evangelou,Claudia P. Cabrera,He Gao,Meixia Ren,Borbala Mifsud,Ioanna Ntalla,Praveen Surendran,Chunyu Liu,James P. Cook,Aldi T. Kraja,Fotios Drenos,Marie Loh,Niek Verweij,Jonathan Marten,Ibrahim Karaman,Marcelo P. Segura Lepe,Paul F. O'Reilly,Joanne Knight,Harold Snieder,Norihiro Kato,Jiang He,E. Shyong Tai,M. Abdullah Said,David J. Porteous,Maris Alver,Neil Poulter,Martin Farrall,Ron T. Gansevoort,Sandosh Padmanabhan,Reedik Mägi,Alice Stanton,John M. C. Connell,Stephan J. L. Bakker,Andres Metspalu,Denis C. Shields,Simon Thom,Morris Brown,Peter S. Sever,Tõnu Esko,Caroline Hayward,Pim van der Harst,Danish Saleheen,Rajiv Chowdhury,John C. Chambers,Daniel I. Chasman,Aravinda Chakravarti,Christopher Newton-Cheh,Cecilia M. Lindgren,Daniel Levy,Jaspal S. Kooner,Bernard Keavney,Maciej Tomaszewski,Nilesh J. Samani,Joanna M. M. Howson,Martin D. Tobin,Patricia B. Munroe,Georg Ehret,Louise V. Wain,Michael R. Barnes,Joanna Tzoulaki,Mark J. Caulfield,Paul Elliott,Ahmad Vaez,Rick Jansen,Roby Joehanes,Peter J. van der Most,A. Mesut Erzurumluoglu,Paul O'Reilly,Lynda M. Rose,Germaine C. Verwoert,Jouke-Jan Hottenga,Rona J. Strawbridge,Dan E. Arking,Shih-Jen Hwang,Xiuqing Guo,Zoltán Kutalik,Stella Trompet,Nick Shrine,Alexander Teumer,Janina S. Ried,Joshua C. Bis,Albert V. Smith,Najaf Amin,Ilja M. Nolte,Leo-Pekka Lyytikäinen,Anubha Mahajan,Nicholas J. Wareham,Edith Hofer,Peter K. Joshi,Kati Kristiansson,Michela Traglia,Aki S. Havulinna,Anuj Goel,Mike A. Nalls,Siim Sõber,Dragana Vuckovic,Jian'an Luan,Fabiola Del Greco M,Kristin L. Ayers,Jaume Marrugat,Daniela Ruggiero,Lorna M. Lopez,Teemu J. Niiranen,Stefan Enroth,Anne U. Jackson,Christopher P. Nelson,Jennifer E. Huffman,Weihua Zhang,Ilaria Gandin,Sarah E. Harris,Tatijana Zemonik,Yingchang Lu,Nabi Shah,Martin H. de Borst,Massimo Mangino,Bram P. Prins,Archie Campbell,Ruifang Li-Gao,Ganesh Chauhan,Christopher Oldmeadow,Gonçalo R. Abecasis,Maryam Abedi,Caterina Barbieri,Chiara Batini,Tineka Blake,Michael Boehnke,Erwin P. Bottinger,Peter S. Braund,Marco Brumat,Harry Campbell,Massimiliano Cocca,Francis S. Collins,Heather J. Cordell,Jeffrey Damman,Gail Davies,Eco J. C. de Geus,Renée de Mutsert,Joris Deelen,Yusuf Demirkale,Alex S. F. Doney,Marcus Dörr,Teresa Ferreira,Mattias Frånberg,Vilmantas Giedraitis,Christian Gieger,Franco Giulianini,Alan J. Gow,Anders Hamsten,Tamara B. Harris,Albert Hofman,Elizabeth G. Holliday,Marjo-Riitta Järvelin,Åsa Johansson,Andrew D. Johnson,Pekka Jousilahti,Antti Jula,Mika Kähönen,Sekar Kathiresan,Kay-Tee Khaw,Ivana Kolcic,Seppo Koskinen,Claudia Langenberg,Marty Larson,Lenore J. Launer,Benjamin Lehne,David C. Liewald,Li Lin,Lars Lind,François Mach,Chrysovalanto Mamasoula,Cristina Menni,Yuri Milaneschi,Anna Morgan,Andrew D. Morris,Alanna C. Morrison,Peter J. Munson,Priyanka Nandakumar,Quang Tri Nguyen,Teresa Nutile,Albertine J. Oldehinkel,Ben A. Oostra,Elin Org,Aarno Palotie,Guillaume Paré,Alison Pattie,Brenda W.J.H. Penninx,Peter P. Pramstaller,Olli T. Raitakari,Kenneth Rice,Paul M. Ridker,Harriëtte Riese,Samuli Ripatti,Antonietta Robino,Jerome I. Rotter,Igor Rudan,Yasaman Saba,Aude Saint Pierre,Cinzia Sala,Antti-Pekka Sarin,Reinhold Schmidt,Rodney J. Scott,Marc A. Seelen,David S. Siscovick,Rossella Sorice,David J. Stott,Johan Sundström,Morris A. Swertz,Kent D. Taylor,Ioanna Tzoulaki,Christophe Tzourio,André G. Uitterlinden,Uwe Völker,Peter Vollenweider,Sarah H. Wild,Gonneke Willemsen,Alan F. Wright,Jie Yao,Sébastien Thériault,David Conen,Attia John,Stéphanie Debette,Dennis O. Mook-Kanamori,Eleftheria Zeggini,Tim D. Spector,Colin N. A. Palmer,Anne-Claire Vergnaud,Ruth J. F. Loos,Ozren Polasek,John M. Starr,Giorgia Girotto,C M Lindgren,Veronique Vitart,Jaakko Tuomilehto,Ulf Gyllensten,Paul Knekt,Ian J. Deary,Marina Ciullo,Roberto Elosua,Bernard Keavney,Andrew A. Hicks,Robert A. Scott,Paolo Gasparini,Maris Laan,Yongmei Liu,Hugh Watkins,Catharina A. Hartman,Veikko Salomaa,Daniela Toniolo,Markus Perola,James F. Wilson,Helena Schmidt,Jing Hua Zhao,Terho Lehtimäki,Cornelia M. van Duijn,Vilmundur Gudnason,Bruce M. Psaty,Annette Peters,Rainer Rettig,Alan James,J. Wouter Jukema,David P. Strachan,Walter Palmas,Erik Ingelsson,Dorret I. Boomsma,Oscar H. Franco,Murielle Bochud,Andrew P. Morris +267 more
TL;DR: Results from genetic risk score models raise the possibility of a precision medicine approach through early lifestyle intervention to offset the impact of blood pressure–raising genetic variants on future cardiovascular disease risk.