N
Nilesh J. Samani
Researcher at University of Leicester
Publications - 836
Citations - 127518
Nilesh J. Samani is an academic researcher from University of Leicester. The author has contributed to research in topics: Genome-wide association study & Population. The author has an hindex of 149, co-authored 779 publications receiving 113545 citations. Previous affiliations of Nilesh J. Samani include University Hospitals of Leicester NHS Trust & Glenfield Hospital.
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Journal ArticleDOI
A Genome-Wide Association Study Identifies LIPA as a Susceptibility Gene for Coronary Artery Disease
Philipp S. Wild,Tanja Zeller,Arne Schillert,Silke Szymczak,Christoph Sinning,Arne Deiseroth,Renate B. Schnabel,Edith Lubos,Till Keller,Medea S. Eleftheriadis,Christoph Bickel,Hans J. Rupprecht,Sandra Wilde,Heidi Rossmann,Patrick Diemert,L. Adrienne Cupples,Claire Perret,Jeanette Erdmann,Klaus Stark,Marcus E. Kleber,Stephen E. Epstein,Benjamin F. Voight,Kari Kuulasmaa,Mingyao Li,Arne Schäfer,Norman Klopp,Peter S. Braund,Hendrik B. Sager,Serkalem Demissie,Carole Proust,Inke R. König,Heinz Erich Wichmann,Wibke Reinhard,Michael M. Hoffmann,Jarmo Virtamo,Mary Susan Burnett,David S. Siscovick,Per-Gunnar Wiklund,Liming Qu,Nour Eddine El Mokthari,John R. Thompson,Annette Peters,Albert V. Smith,Emmanuelle Yon,Jens Baumert,Christian Hengstenberg,Winfried März,Philippe Amouyel,Joseph M. Devaney,Stephen M. Schwartz,Olli Saarela,Nehal N. Mehta,Diana Rubin,Kaisa Silander,Alistair S. Hall,Jean Ferrières,Tamara B. Harris,Olle Melander,Frank Kee,Hakon Hakonarson,Juergen Schrezenmeir,Vilmundur Gudnason,Roberto Elosua,Dominique Arveiler,Alun Evans,Daniel J. Rader,Thomas Illig,Stefan Schreiber,Joshua C. Bis,David Altshuler,Maryam Kavousi,Jaqueline C M Witteman,André G. Uitterlinden,Albert Hofman,Aaron R. Folsom,Maja Barbalić,Eric Boerwinkle,Sekar Kathiresan,Muredach P. Reilly,Christopher J. O'Donnell,Nilesh J. Samani,Heribert Schunkert,François Cambien,Karl J. Lackner,Laurence Tiret,Veikko Salomaa,Thomas Münzel,Andreas Ziegler,Stefan Blankenberg +88 more
TL;DR: A genome-wide association and global gene expression study to identify functionally relevant variants affecting the risk of coronary artery disease (CAD) led to the identification of the novel functional CAD susceptibility locus LIPA, located on chromosome 10q23.31.
Journal ArticleDOI
Association of rare and common variation in the lipoprotein lipase gene with coronary artery disease.
Amit Khera,Amit Khera,Hong-Hee Won,Gina M. Peloso,Gina M. Peloso,Colm O'Dushlaine,Dajiang J. Liu,Nathan O. Stitziel,Pradeep Natarajan,Pradeep Natarajan,Akihiro Nomura,Akihiro Nomura,Connor A. Emdin,Connor A. Emdin,Namrata Gupta,Ingrid B. Borecki,Rosanna Asselta,Stefano Duga,Piera Angelica Merlini,Adolfo Correa,Thorsten Kessler,James G. Wilson,Matthew J. Bown,Alistair S. Hall,Peter S. Braund,David J. Carey,Michael F. Murray,H. Lester Kirchner,Joseph B. Leader,Daniel R. Lavage,J. Neil Manus,Dustin N. Hartzel,Nilesh J. Samani,Heribert Schunkert,Jaume Marrugat,Roberto Elosua,Ruth McPherson,Martin Farrall,Hugh Watkin,Eric S. Lander,Daniel J. Rader,J Danesh,J Danesh,J Danesh,Diego Ardissino,Stacey Gabriel,Cristen J. Willer,Gonçalo R. Abecasis,Danish Saleheen,Frederick E. Dewey,Sekar Kathiresan,Sekar Kathiresan +51 more
TL;DR: The presence of rare damaging mutations in LPL was significantly associated with higher triglyceride levels and presence of coronary arteries disease, and further research is needed to assess whether there are causal mechanisms by which heterozygous lipoprotein lipase deficiency could lead to coronary artery disease.
Journal ArticleDOI
Association of the PHACTR1/EDN1 Genetic Locus With Spontaneous Coronary Artery Dissection
David Adlam,Timothy M. Olson,Nicolas Combaret,Jason C. Kovacic,Siiri E. Iismaa,Abtehale Al-Hussaini,Megan M. O’Byrne,Sara Bouajila,Adrien Georges,K Mishra,Peter S. Braund,Valentina d'Escamard,S Huang,M Margaritis,Christopher P. Nelson,M. De Andrade,Daniella Kadian-Dodov,C A Welch,S Mazurkiewicz,Xavier Jeunemaitre,Wong Cmy.,Eleni Giannoulatou,Michael J. Sweeting,David W.M. Muller,Alice Wood,Lucy McGrath-Cadell,Diane Fatkin,Sally L. Dunwoodie,Richard P. Harvey,Cameron J. Holloway,Empana J-P.,Xavier Jouven,Jeffrey W. Olin,Rajiv Gulati,Marysia S. Tweet,Sharonne N. Hayes,Nilesh J. Samani,Robert M. Graham,Pascal Motreff,Nabila Bouatia-Naji,Nabila Bouatia-Naji +40 more
TL;DR: The first genetic risk factor for SCAD was identified in the largest study conducted to date for this condition, and this genetic link may contribute to the clinical overlap between SCAD and FMD.
Journal ArticleDOI
Polygenic prediction of educational attainment within and between families from genome-wide association analyses in 3 million individuals
Aysu Okbay,Yeda Wu,Nancy Wang,Hariharan Jayashankar,Michael Bennett,Seyed Moeen Nehzati,Julia Sidorenko,Hyeokmoon Kweon,Grant Goldman,Tamara Gjorgjieva,Yunxuan Jiang,B. Hicks,Chao Tian,David A. Hinds,Rafael Ahlskog,Patrik K. E. Magnusson,Sven Oskarsson,Caroline Hayward,Archie Campbell,David J. Porteous,Jeremy Freese,Pamela Herd,Michelle Agee,Babak Alipanahi,Adam Auton,Robert K. Bell,Katarzyna Bryc,Sarah L. Elson,Pierre Fontanillas,Nicholas A. Furlotte,Karen E. Huber,Aaron Kleinman,Nadia K. Litterman,Jennifer C. McCreight,Matthew H. McIntyre,Joanna L. Mountain,Carrie A.M. Northover,Steven J. Pitts,J. Fah Sathirapongsasuti,Olga V. Sazonova,Janie F. Shelton,Suyash Shringarpure,Joyce Y. Tung,Vladimir Vacic,Catherine H. Wilson,Mark Alan Fontana,Tune H. Pers,Cornelius A. Rietveld,Guo-Bo Chen,Valur Emilsson,S. Fleur W. Meddens,Joseph K. Pickrell,Kevin Thom,Pascal Timshel,Ronald de Vlaming,Abdel Abdellaoui,Tarunveer S. Ahluwalia,Jonas Bacelis,Clemens Baumbach,Gyda Bjornsdottir,Johannes H. Brandsma,Maria Pina Concas,Jaime Derringer,Tessel E. Galesloot,Giorgia Girotto,Richa Gupta,Leanne M. Hall,Sarah E. Harris,Edith Hofer,Momoko Horikoshi,Jennifer E. Huffman,Kadri Kaasik,Ioanna P. Kalafati,Robert Karlsson,Jari Lahti,S. J. van der Lee,Christiaan de Leeuw,Penelope A. Lind,Karl-Oskar Lindgren,Tian Liu,Massimo Mangino,Jonathan Marten,Evelin Mihailov,Michael B. Miller,Peter J. van der Most,Christopher Oldmeadow,Antony Payton,Natalia Pervjakova,Wouter J. Peyrot,Yong-chao Qian,Olli T. Raitakari,Rico Rueedi,Erika Salvi,Börge Schmidt,Katharina E. Schraut,Jianxin Shi,Raymond A. Poot,Beate St Pourcain,Alexander Teumer,Gudmar Thorleifsson,Niek Verweij,Dragana Vuckovic,Juergen Wellmann,Harm-Jan Westra,Jingyun Yang,Wei Zhao,Zhihong Zhu,Behrooz Z. Alizadeh,Najaf Amin,Andrew Bakshi,Sebastian E. Baumeister,Ginevra Biino,Klaus Bønnelykke,Patricia A. Boyle,Harry Campbell,Francesco P. Cappuccio,Gail Davies,Jan-Emmanuel De Neve,Panos Deloukas,Ilja Demuth,Jun Ding,Peter Eibich,Lewin Eisele,Niina Eklund,David M. Evans,Jessica D. Faul,Mary F. Feitosa,Andreas J. Forstner,Ilaria Gandin,Bjarni Kristinn Gunnarsson,Bjarni V. Halldorsson,Tamara B. Harris,Andrew C. Heath,Lynne J. Hocking,Elizabeth G. Holliday,Georg Homuth,Michael A. Horan,Jouke-Jan Hottenga,Philip L. De Jager,Peter K. Joshi,Astanand Jugessur,Marika Kaakinen,Mika Kähönen,Stavroula Kanoni,Liisa Keltigangas-Jarvinen,Lambertus A. Kiemeney,Ivana Kolcic,Seppo Koskinen,Aldi T. Kraja,Martin Kroh,Zoltán Kutalik,Antti Latvala,Lenore J. Launer,Maël Lebreton,Douglas F. Levinson,Paul Lichtenstein,Peter Lichter,David C. Liewald,Anu Loukola,Pamela A. F. Madden,Reedik Mägi,Tomi Mäki-Opas,Riccardo E. Marioni,Pedro Marques-Vidal,Gerardus A. Meddens,George McMahon,Christa Meisinger,Thomas Meitinger,Y. Milaneschi,Lili Milani,Grant W. Montgomery,Ronny Myhre,Christopher P. Nelson,Dale R. Nyholt,William E R Ollier,Aarno Palotie,Lavinia Paternoster,Nancy L. Pedersen,K. Petrovic,Katri Räikkönen,Susan M. Ring,Antonietta Robino,Olga Rostapshova,Igor Rudan,Aldo Rustichini,Veikko Salomaa,Alan R. Sanders,Antti-Pekka Sarin,E. E. Schmidt,Rodney J. Scott,Blair H. Smith,Jennifer A. Smith,Jan A. Staessen,Elisabeth Steinhagen-Thiessen,Konstantin Strauch,Antonio Terracciano,Martin D. Tobin,Sheila Ulivi,Simona Vaccargiu,Lydia Quaye,Frank J. A. van Rooij,Cristina Venturini,Anna A. E. Vinkhuyzen,Uwe Völker,Henry Völzke,Judith M. Vonk,Diego Vozzi,Johannes Waage,Erin B. Ware,Gonneke Willemsen,J. Attia,David A. Bennett,Klaus Berger,Lars Bertram,Hans Bisgaard,Dorret I. Boomsma,Ingrid B. Borecki,Ute Bültmann,Christopher F. Chabris,Francesco Cucca,Daniele Cusi,Ian J. Deary,George Dedoussis,Cornelia M. van Duijn,Johan G. Eriksson,Barbara Franke,Lude Franke,Paolo Gasparini,Pablo V. Gejman,Christian Gieger,Hans J. Grabe,Jacob Gratten,Patrick J. F. Groenen,Vilmundur Gudnason,P. Van der Harst,Wolfgang Hoffmann,Elina Hyppönen,William G. Iacono,Bo Jacobsson,Marjo-Riitta Järvelin,Karl-Heinz Jöckel,Jaakko Kaprio,Sharon L.R. Kardia,Terho Lehtimäki,Steven F. Lehrer,Nicholas G. Martin,Matt McGue,Andres Metspalu,Neil Pendleton,Brenda W.J.H. Penninx,Markus Perola,Nicola Pirastu,Mario Pirastu,Ozren Polasek,Danielle Posthuma,Christine Power,Michael A. Province,Nilesh J. Samani,David Schlessinger,Reinhold Schmidt,Thorkild I. A. Sørensen,Tim D. Spector,Kari Stefansson,Unnur Thorsteinsdottir,Roy Thurik,Nicholas J. Timpson,Henning Tiemeier,André G. Uitterlinden,Veronique Vitart,Peter Vollenweider,David R. Weir,James F. Wilson,Alan F. Wright,R. Kroeger,George Davey Smith,Albert Hofman,David Laibson,Sarah E. Medland,Jian Yang,Tõnu Esko,Chelsea Coleman Watson,Jonathan B. Jala,Dalton Conley,Philipp Koellinger,Magnus Johannesson,Michelle N. Meyer,James J. Lee,Augustine Kong,Loic Yengo,David Cesarini,Patrick Turley,Peter M. Visscher,Jonathan P. Beauchamp,Daniel J. Benjamin,Alexander I. Young +294 more
TL;DR: This paper conducted a genome-wide association study (GWAS) of educational attainment (EA) in a sample of ~3 million individuals and identified 3,952 approximately uncorrelated single-nucleotide polymorphisms (SNPs).
Journal ArticleDOI
Causal Assessment of Serum Urate Levels in Cardiometabolic Diseases Through a Mendelian Randomization Study.
Tanya Keenan,Wei Zhao,Asif Rasheed,Weang K. Ho,Rainer Malik,Janine F. Felix,Robin Young,Nabi Shah,Maria Samuel,Nasir Sheikh,Megan L. Mucksavage,Omar Shah,Jin Li,Michael Morley,Annika Laser,Nadeem Hayat Mallick,Khan Shah Zaman,M. Ishaq,Syed Zahed Rasheed,Fazal Ur Rehman Memon,Faisal Ahmed,Bashir Hanif,Muhammad Shakir Lakhani,Muhammad Fahim,Mohammad Ishaq,Naresh Kumar Shardha,Naveeduddin Ahmed,Khalid Mahmood,Waseem Iqbal,Saba Akhtar,Rabia Raheel,Christopher J. O'Donnell,Christian Hengstenberg,W. März,Sekar Kathiresan,Nilesh J. Samani,Anuj Goel,Jemma C. Hopewell,John C. Chambers,Yu-Ching Cheng,Pankaj Sharma,Qiong Yang,Jonathan Rosand,Giorgio B. Boncoraglio,Shahana Urooj Kazmi,Hakon Hakonarson,Anna Köttgen,Andreas P. Kalogeropoulos,Philippe M. Frossard,Ayeesha Kamran Kamal,Martin Dichgans,Thomas P. Cappola,Muredach P. Reilly,John Danesh,Daniel J. Rader,Benjamin F. Voight,Danish Saleheen +56 more
TL;DR: Evidence from this study does not support a causal role of circulating serum urate levels in T2DM, CHD, ischemic stroke, or HF, and decreasing serum Urate levels may not translate into risk reductions for cardiometabolic conditions.