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Nilesh J. Samani
Researcher at University of Leicester
Publications - 836
Citations - 127518
Nilesh J. Samani is an academic researcher from University of Leicester. The author has contributed to research in topics: Genome-wide association study & Population. The author has an hindex of 149, co-authored 779 publications receiving 113545 citations. Previous affiliations of Nilesh J. Samani include University Hospitals of Leicester NHS Trust & Glenfield Hospital.
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Journal ArticleDOI
Genetic predisposition to higher blood pressure increases coronary artery disease risk
Wolfgang Lieb,Henning Jansen,Christina Loley,Michael J. Pencina,Christopher P. Nelson,Christopher P. Nelson,Christopher Newton-Cheh,Christopher Newton-Cheh,Sekar Kathiresan,Sekar Kathiresan,Muredach P. Reilly,Themistocles L. Assimes,Eric Boerwinkle,Alistair S. Hall,Christian Hengstenberg,Reijo Laaksonen,Ruth McPherson,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Andreas Ziegler,Annette Peters,John R. Thompson,Inke R. König,Jeanette Erdmann,Nilesh J. Samani,Nilesh J. Samani,Ramachandran S. Vasan,Heribert Schunkert +27 more
TL;DR: Most blood pressure–associated polymorphisms also confer an increased risk for coronary artery disease, consistent with a causal relationship of increasing blood pressure to coronary artery Disease.
Journal ArticleDOI
Insertion/deletion polymorphism in the angiotensin-converting enzyme gene and risk of restenosis after coronary angioplasty
Nilesh J. Samani,M. J. Brack,James H. S. Cullen,D.P. de Bono,Anthony H. Gershlick,Daniel Martin,David Lodwick,John D. Swales,A. Chauhan,Alex Harley +9 more
TL;DR: It is concluded that, in patients undergoing elective PTCA, the I/D polymorphism in the ACE gene does not influence the extent of restenosis, and typing for the polymorphism will not be a useful predictor of risk before the procedure.
Journal ArticleDOI
Whole-genome sequencing identifies rare genotypes in COMP and CHADL associated with high risk of hip osteoarthritis.
Unnur Styrkarsdottir,Hannes Helgason,Hannes Helgason,Asgeir Sigurdsson,Gudmundur L. Norddahl,Arna B Agustsdottir,Louise N. Reynard,Amanda Villalvilla,Gisli H. Halldorsson,Aslaug Jonasdottir,Audur Magnusdottir,Asmundur Oddson,Gerald Sulem,Florian Zink,Gardar Sveinbjornsson,Agnar Helgason,Agnar Helgason,Hrefna Johannsdottir,Anna Helgadottir,Hreinn Stefansson,Solveig Gretarsdottir,Thorunn Rafnar,Ina S. Almdahl,Anne Brækhus,Tormod Fladby,Tormod Fladby,Geir Selbæk,Geir Selbæk,Farhad Hosseinpanah,Fereidoun Azizi,Jung Min Koh,Nelson L.S. Tang,Maryam S. Daneshpour,Jose I. Mayordomo,Corrine K. Welt,Peter S. Braund,Peter S. Braund,Nilesh J. Samani,Nilesh J. Samani,Lambertus A. Kiemeney,L. Stefan Lohmander,Claus Christiansen,Ole A. Andreassen,Olafur Th Magnusson,Gisli Masson,Augustine Kong,Ingileif Jonsdottir,Ingileif Jonsdottir,Daniel F. Gudbjartsson,Daniel F. Gudbjartsson,Patrick Sulem,Helgi Jonsson,John Loughlin,Thorvaldur Ingvarsson,Thorvaldur Ingvarsson,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Kari Stefansson,Kari Stefansson +58 more
TL;DR: A genome-wide association study of total hip replacements, based on variants identified through whole-genome sequencing, shows that the full-length CHADL transcript is expressed in cartilage and discovers two rare signals that strongly associate with osteoarthritis total hip replacement.
Journal ArticleDOI
Analysis of predicted loss-of-function variants in UK Biobank identifies variants protective for disease
Connor A. Emdin,Connor A. Emdin,Amit Khera,Amit Khera,Mark Chaffin,Mark Chaffin,Derek Klarin,Derek Klarin,Pradeep Natarajan,Pradeep Natarajan,Krishna G. Aragam,Krishna G. Aragam,Mary E. Haas,Mary E. Haas,Alexander G. Bick,Alexander G. Bick,Seyedeh M. Zekavat,Seyedeh M. Zekavat,Seyedeh M. Zekavat,Akihiro Nomura,Akihiro Nomura,Diego Ardissino,James G. Wilson,Heribert Schunkert,Ruth McPherson,Hugh Watkins,Hugh Watkins,Roberto Elosua,Matthew J. Bown,Nilesh J. Samani,Usman Baber,Jeanette Erdmann,Namrata Gupta,John Danesh,John Danesh,Daniel I. Chasman,Paul M. Ridker,Joshua C. Denny,Lisa Bastarache,Judith H. Lichtman,Gail D'Onofrio,Jennifer A. Mattera,John A. Spertus,Wayne H-H Sheu,Kent D. Taylor,Bruce M. Psaty,Bruce M. Psaty,Stephen S. Rich,Wendy S. Post,Jerome I. Rotter,Yii-Der Ida Chen,Harlan M. Krumholz,Danish Saleheen,Stacey Gabriel,Sekar Kathiresan,Sekar Kathiresan +55 more
TL;DR: In this paper, the authors found that less than 3% of protein-coding genetic variants are predicted to result in loss of protein function through the introduction of a stop codon, frameshift, or the disruption of an essential splice site; however, such predicted loss-of-function (pLOF) variants provide insight into effector transcript and direction of biological effect.
Journal ArticleDOI
Leukocyte telomere length and coronary artery calcification
Arch G. Mainous,Veryan Codd,Vanessa A. Diaz,U. Joseph Schoepf,Charles J. Everett,Marty S. Player,Nilesh J. Samani +6 more
TL;DR: In this paper, the authors examined the association of telomere length with coronary artery calcification in middle aged adults and found that the relation of length is negatively associated with the presence of coronary atherosclerosis.