N
Nilesh J. Samani
Researcher at University of Leicester
Publications - 836
Citations - 127518
Nilesh J. Samani is an academic researcher from University of Leicester. The author has contributed to research in topics: Genome-wide association study & Population. The author has an hindex of 149, co-authored 779 publications receiving 113545 citations. Previous affiliations of Nilesh J. Samani include University Hospitals of Leicester NHS Trust & Glenfield Hospital.
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Journal ArticleDOI
Telomere biology in heart failure.
TL;DR: The emerging role of telomere biology in the pathophysiology of heart failure is discussed, which is a driving force by which genetic and environmental factors jointly affect biological aging, and possibly the risk for developing age‐associated diseases.
Journal ArticleDOI
Genetic variation associated with longer telomere length increases risk of chronic lymphocytic leukemia
Juhi Ojha,Veryan Codd,Veryan Codd,Christopher P. Nelson,Christopher P. Nelson,Nilesh J. Samani,Nilesh J. Samani,Ivan Smirnov,Nils R. Madsen,Helen M. Hansen,Adam J. de Smith,Paige M. Bracci,John K. Wiencke,Margaret Wrensch,Joseph L. Wiemels,Kyle M. Walsh +15 more
TL;DR: Genetic variants in TERC, TERT, and OBFC1 are associated with both longer LTL and increased CLL risk, suggesting that the role of telomere length in CLL etiology may be distinct from its role in disease progression.
Journal ArticleDOI
Psychological morbidity and illness appraisals of patients with cardiac and non-cardiac chest pain attending a Rapid Access Chest Pain Clinic: a longitudinal cohort study
TL;DR: Clinical levels of psychological morbidity are evident in the immediate and long-term aftermath of a visit to a Rapid Access Chest Pain Clinic, despite early access and provision of reassurance.
Journal ArticleDOI
Exome Chip Meta-analysis Fine Maps Causal Variants and Elucidates the Genetic Architecture of Rare Coding Variants in Smoking and Alcohol Use
David M. Brazel,Yu Jiang,Jordan M. Hughey,Valérie Turcot,Valérie Turcot,Xiaowei Zhan,Jian Gong,Chiara Batini,J. Dylan Weissenkampen,Mengzhen Liu,Praveen Surendran,Robin Young,Daniel R. Barnes,Sune F. Nielsen,Asif Rasheed,M Samuel,Wei Zhao,Jukka Kontto,Markus Perola,Muriel Caslake,Anton J. M. De Craen,S. Trompet,Maria Uria-Nickelsen,Anders Mälarstig,Dermot F. Reily,Maarten Hoek,Thomas F. Vogt,J. Wouter Jukema,Naveed Sattar,Ian Ford,Chris J. Packard,Dewan S. Alam,Abdulla Al Shafi Majumder,Emanuele Di Angelantonio,Rajiv Chowdhury,Philippe Amouyel,Dominique Arveiler,Stefan Blankenberg,Jean Ferrières,Frank Kee,Kari Kuulasmaa,Martina Müller-Nurasyid,Giovanni Veronesi,Jarmo Virtamo,Philippe M. Frossard,Børge Grønne Nordestgaard,Danish Saleheen,J Danesh,Adam S. Butterworth,Joanna M. M. Howson,A. Mesut Erzurumluoglu,Victoria E. Jackson,Carl A. Melbourne,Tibor V. Varga,Helen R. Warren,Vinicius Tragante,Ioanna Tachmazidou,Sarah E. Harris,Evangelos Evangelou,Jonathan Marten,Weihua Zhang,Weihua Zhang,Elisabeth Altmaier,Jian'an Luan,Claudia Langenberg,Robert A. Scott,Hanieh Yaghootkar,Kathleen Stirrups,Stavroula Kanoni,Eirini Marouli,F Karpe,Anna F. Dominiczak,Peter S. Sever,Neil Poulter,Olov Rolandsson,Clemens Baumbach,Saima Afaq,John C. Chambers,Jaspal S. Kooner,Nicholas J. Wareham,Frida Renström,Göran Hallmans,Riccardo E. Marioni,Janie Corley,John M. Starr,Niek Verweij,Rudolf A. de Boer,Peter van der Meer,Ersin Yavas,Ilonca Vaartjes,Michiel L. Bots,Folkert W. Asselbergs,Hans J. Grabe,Henry Völzke,Matthias Nauck,Stefan Weiss,Paul D.P. Pharoah,Alison M. Dunning,Joe Dennis,Deborah J. Thompson,Kyriaki Michailidou,Douglas F. Easton,Antonis C. Antoniou,Jessica Tyrrell,Evelin Mihailov,Nilesh J. Samani,Kaixin Zhou,Matt J. Neville,Andres Metspalu,Colin N. A. Palmer,Ian P. Hall,David P. Strachan,Ian J. Deary,Timothy M. Frayling,Caroline Hayward,Pim van der Harst,Eleftheria Zeggini,Patricia B. Munroe,Jan-Håkan Jansson,Paul W. Franks,Panos Deloukas,Mark J. Caulfield,Louise V. Wain,Martin D. Tobin,Sarah Bertelsen,Yi Ling Chou,Jessica D. Faul,Jeff Haessler,Anke R. Hammerschlag,Chris Hsu,Manav Kapoor,Dongbing Lai,Nhung Le,Christiaan de Leeuw,Anu Loukola,Massimo Mangino,Massimo Mangino,Giorgio Pistis,Beenish Qaiser,Rebecca Rohde,Yaming Shao,Heather M. Stringham,Leah Wetherill,Arpana Agrawal,Laura J. Bierut,Chu Chen,Chu Chen,Charles B. Eaton,Alison Goate,Christopher A. Haiman,Andrew C. Heath,William G. Iacono,Nicholas G. Martin,Tinca J. C. Polderman,Alex P. Reiner,Alex P. Reiner,John P. Rice,David Schlessinger,H. Steven Scholte,Jennifer A. Smith,Jean-Claude Tardif,Jean-Claude Tardif,Hilary A. Tindle,Andries R. van der Leij,Michael Boehnke,Jenny Chang-Claude,Francesco Cucca,Sean P. David,Tatiana Foroud,Sharon L.R. Kardia,Charles Kooperberg,Markku Laakso,Guillaume Lettre,Guillaume Lettre,Pamela A. F. Madden,Matt McGue,Kari E. North,Danielle Posthuma,Tim D. Spector,Daniel O. Stram,David R. Weir,Jaakko Kaprio,Gonçalo R. Abecasis,Gonçalo R. Abecasis,Dajiang J. Liu,Scott I. Vrieze +185 more
TL;DR: Fine-mapping genome-wide association study loci identifies specific variants contributing to the biological etiology of substance use behavior, including nonsynonymous/loss-of-function coding variants.
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk
Georg Ehret,Patricia B. Munroe,Kenneth Rice,Murielle Bochud,Andrew D. Johnson,Daniel I. Chasman,Albert V. Smith,Martin D. Tobin,Germaine C. Verwoert,Shih-Jen Hwang,Vasyl Pihur,Peter Vollenweider,Paul F. O'Reilly,Najaf Amin,Jennifer L. Bragg-Gresham,Alexander Teumer,Nicole L. Glazer,Lenore J. Launer,Jing Hua Zhao,Yurii S. Aulchenko,Simon Heath,Siim Sõber,Afshin Parsa,Jian'an Luan,Pankaj Arora,Abbas Dehghan,Feng Zhang,Gavin Lucas,Andrew A. Hicks,Anne U. Jackson,John F. Peden,Toshiko Tanaka,Sarah H. Wild,Igor Rudan,Wilmar Igl,Yuri Milaneschi,Alex Parker,Cristiano Fava,John C. Chambers,Ervin R. Fox,Meena Kumari,Min Jin Go,Pim van der Harst,Wen Hong Linda Kao,Marketa Sjögren,D. G. Vinay,Myriam Alexander,Yasuharu Tabara,Sue Shaw-Hawkins,Peter H. Whincup,Yongmei Liu,Gang Shi,Johanna Kuusisto,Bamidele O. Tayo,Mark Seielstad,Xueling Sim,Khanh-Dung H. Nguyen,Terho Lehtimäki,Giuseppe Matullo,Ying Wu,Tom R. Gaunt,N. Charlotte Onland-Moret,Mark E. Cooper,Carl G. P. Platou,Elin Org,Rebecca Hardy,Santosh Dahgam,Jutta Palmen,Veronique Vitart,Peter S. Braund,Tatiana Kuznetsova,Cuno S.P.M. Uiterwaal,Adebowale Adeyemo,Walter Palmas,Harry Campbell,Barbara Ludwig,Maciej Tomaszewski,Ioanna Tzoulaki,Nicholette D. Palmer,Thor Aspelund,Melissa Garcia,Yen Pei C. Chang,Jeffrey R. O'Connell,Nanette I. Steinle,Diederick E. Grobbee,Dan E. Arking,Sharon L.R. Kardia,Alanna C. Morrison,Dena G. Hernandez,Samer S. Najjar,Wendy L. McArdle,David Hadley,Morris J. Brown,John M. C. Connell,Aroon D. Hingorani,Ian N.M. Day,Debbie A Lawlor,John Beilby,Robert Lawrence,Robert Clarke,Jemma C. Hopewell,Halit Ongen,Albert W. Dreisbach,Yali Li,J. Hunter Young,Joshua C. Bis,Mika Kähönen,Jorma Viikari,Linda S. Adair,Nanette R. Lee,Ming-Huei Chen,Matthias Olden,Cristian Pattaro,Judith A. Hoffman Bolton,Anna Koettgen,Sven Bergmann,Vincent Mooser,Nish Chaturvedi,Timothy M. Frayling,M. Mazharul Islam,Tazeen H. Jafar,Jeanette Erdmann,Smita R. Kulkarni,Stefan R. Bornstein,Juergen Graessler,Leif Groop,Benjamin F. Voight,Johannes Kettunen,Philip N. Howard,Andrew M. Taylor,Simonetta Guarrera,Fulvio Ricceri,Valur Emilsson,Andrew S. Plump,Inês Barroso,Kay-Tee Khaw,Alan B. Weder,Steven C. Hunt,Yan V. Sun,Richard N. Bergman,Francis S. Collins,Lori L. Bonnycastle,Laura J. Scott,Heather M. Stringham,Leena Peltonen,Markus Perola,Erkki Vartiainen,Stefan-Martin Brand,Jan A. Staessen,Thomas J. Wang,Paul Burton,María Soler Artigas,Yanbin Dong,Harold Snieder,Xiaoling Wang,Haidong Zhu,Kurt Lohman,Megan E. Rudock,Susan R. Heckbert,Nicholas L. Smith,Kerri L. Wiggins,Ayo P. Doumatey,Daniel Shriner,Gudrun Veldre,Margus Viigimaa,Sanjay Kinra,Dorairaj Prabhakaran,Vikal Tripathy,Carl D. Langefeld,Annika Rosengren,Dag S. Thelle,Anna Maria Corsi,Andrew B. Singleton,Terrence Forrester,Gina Hilton,Colin A. McKenzie,Tunde Salako,Naoharu Iwai,Yoshikuni Kita,Toshio Ogihara,Takayoshi Ohkubo,Tomonori Okamura,Hirotsugu Ueshima,Satoshi Umemura,Susana Eyheramendy,Thomas Meitinger,H.-Erich Wichmann,Yoon Shin Cho,Hyung Lae Kim,Jong-Young Lee,James Scott,Joban Sehmi,Weihua Zhang,Bo Hedblad,Peter Nilsson,George Davey Smith,Andrew Wong,Narisu Narisu,Alena Stančáková,Leslie J. Raffel,Jie Yao,Sekar Kathiresan,Christopher J. O'Donnell,Stephen M. Schwartz,M. Arfan Ikram,W. T. Longstreth,Thomas H. Mosley,Sudha Seshadri,Nick Shrine,Louise V. Wain,Mario A. Morken,Amy J. Swift,Jaana Laitinen,Inga Prokopenko,Paavo Zitting,Jackie A. Cooper,Steve E. Humphries,John Danesh,Asif Rasheed,Anuj Goel,Anders Hamsten,Hugh Watkins,Stephan J. L. Bakker,Wiek H. van Gilst,C. S. Janipalli,K. Radha Mani,Chittaranjan S. Yajnik,Albert Hofman,Francesco U.S. Mattace-Raso,Ben A. Oostra,Ayse Demirkan,Aaron Isaacs,Fernando Rivadeneira,Edward G. Lakatta,Marco Orru,Angelo Scuteri,Mika Ala-Korpela,Antti J. Kangas,Leo-Pekka Lyytikäinen,Pasi Soininen,Taru Tukiainen,Peter Würtz,Rick Twee-Hee Ong,Marcus Doerr,Heyo K. Kroemer,Uwe Voelker,Henry Voelzke,Pilar Galan,Serge Hercberg,Mark Lathrop,Diana Zelenika,Panos Deloukas,Massimo Mangino,Tim D. Spector,Guangju Zhai,James F. Meschia,Mike A. Nalls,Pankaj Sharma,Janoš Terzić,M.V. Kranthi Kumar,Matthew Denniff,Ewa Zukowska-Szczechowska,Lynne E. Wagenknecht,F. Gerald R. Fowkes,Fadi J. Charchar,Peter Schwarz,Caroline Hayward,Xiuqing Guo,Charles N. Rotimi,Michiel L. Bots,Eva Brand,Nilesh J. Samani,Ozren Polasek,Philippa J. Talmud,Fredrik Nyberg,Diana Kuh,Maris Laan,Kristian Hveem,Lyle J. Palmer,Yvonne T. van der Schouw,Juan P. Casas,Karen L. Mohlke,Paolo Vineis,Olli T. Raitakari,Santhi K. Ganesh,Tien Yin Wong,E. Shyong Tai,Richard S. Cooper,Markku Laakso,Dabeeru C. Rao,Tamara B. Harris,Richard W Morris,Anna F. Dominiczak,Mika Kivimäki,Michael Marmot,Tetsuro Miki,Danish Saleheen,Giriraj R. Chandak,Josef Coresh,Gerjan Navis,Veikko Salomaa,Bok-Ghee Han,Xiaofeng Zhu,Jaspal S. Kooner,Olle Melander,Paul M. Ridker,Stefania Bandinelli,Ulf Gyllensten,Alan F. Wright,James F. Wilson,Luigi Ferrucci,Martin Farrall,Jaakko Tuomilehto,Peter P. Pramstaller,Roberto Elosua,Nicole Soranzo,Eric J.G. Sijbrands,David Altshuler,Ruth J. F. Loos,Alan R. Shuldiner,Christian Gieger,Pierre Meneton,André G. Uitterlinden,Nicholas J. Wareham,Vilmundur Gudnason,Jerome I. Rotter,Rainer Rettig,Manuela Uda,David P. Strachan,Jacqueline C. M. Witteman,Anna-Liisa Hartikainen,Jacques S. Beckmann,Eric Boerwinkle,Ramachandran S. Vasan,Michael Boehnke,Martin G. Larson,Marjo-Riitta Järvelin,Bruce M. Psaty,Gonçalo R. Abecasis,Aravinda Chakravarti,Paul Elliott,Cornelia M. van Duijn,Christopher Newton-Cheh,Daniel Levy,Mark J. Caulfield,Toby Johnson +345 more
TL;DR: A new meta-analysis of GWAS data that includes staged follow-up genotyping to identify additional BP loci is reported, providing new insights into the genetics and biology of BP, and suggest novel potential therapeutic pathways for cardiovascular disease prevention.