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Nilesh J. Samani
Researcher at University of Leicester
Publications - 836
Citations - 127518
Nilesh J. Samani is an academic researcher from University of Leicester. The author has contributed to research in topics: Genome-wide association study & Population. The author has an hindex of 149, co-authored 779 publications receiving 113545 citations. Previous affiliations of Nilesh J. Samani include University Hospitals of Leicester NHS Trust & Glenfield Hospital.
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Journal ArticleDOI
Gender and effects of a common genetic variant in the NOS1 regulator NOS1AP on cardiac repolarization in 3761 individuals from two independent populations
Martin D. Tobin,Mika Kähönen,Peter S. Braund,Tuomo Nieminen,Cother Hajat,Maciej Tomaszewski,Jari Viik,Rami Lehtinen,G. André Ng,Peter W. Macfarlane,Paul Burton,Terho Lehtimäki,Nilesh J. Samani +12 more
TL;DR: A common NOS1AP variant prolongs QTc with a difference between genders, and further studies should aim to confirm this finding and to assess whether Nos1AP genotype influences the risk of drug-induced QT prolongation and risk of consequent arrhythmias.
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Dissecting the Roles of MicroRNAs in Coronary Heart Disease via Integrative Genomic Analyses
Tianxiao Huan,Jian Rong,Kahraman Tanriverdi,Qingying Meng,Anindya Bhattacharya,David D. McManus,Roby Joehanes,Themistocles L. Assimes,Ruth McPherson,Nilesh J. Samani,Jeanette Erdmann,Heribert Schunkert,Paul Courchesne,Peter J. Munson,Andrew D. Johnson,Christopher J. O'Donnell,Bin Zhang,Martin G. Larson,Jane E. Freedman,Daniel Levy,Xia Yang +20 more
TL;DR: Novel evidence is provided that miRNAs are important regulators of biological processes involved in CHD via genetic control and via their tight coexpression with mRNAs.
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Rare Protein-Truncating Variants in APOB, Lower Low-Density Lipoprotein Cholesterol, and Protection Against Coronary Heart Disease.
Gina M. Peloso,Akihiro Nomura,Amit Khera,Amit Khera,Mark Chaffin,Hong-Hee Won,Diego Ardissino,John Danesh,John Danesh,John Danesh,Heribert Schunkert,James G. Wilson,Nilesh J. Samani,Nilesh J. Samani,Jeanette Erdmann,Ruth McPherson,Hugh Watkins,Danish Saleheen,Shane A. McCarthy,Tanya M. Teslovich,Joseph B. Leader,H. Lester Kirchner,Jaume Marrugat,Atsushi Nohara,Masa-aki Kawashiri,Hayato Tada,Frederick E. Dewey,David J. Carey,Aris Baras,Sekar Kathiresan,Sekar Kathiresan +30 more
TL;DR: This research presents a novel probabilistic approach that allows us to assess the importance of knowing the carrier and removal status of canine coronavirus, as a source of infection for other animals.
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Socioeconomic status and telomere length: the West of Scotland Coronary Prevention Study
G. D. Batty,Yanzhong Wang,S. W. Brouilette,Paul G. Shiels,Chris J. Packard,Jasbir S. Moore,Nilesh J. Samani,Ian Ford +7 more
TL;DR: In this article, the authors found no strong evidence that any of these four indices of socioeconomic position was robustly related to telomere length, the only exception being employment status: men who reported being out of work had significantly shorter telomeres than those who were employed.
Journal ArticleDOI
Machine learning based on biomarker profiles identifies distinct subgroups of heart failure with preserved ejection fraction
Rebecca J. Woolley,Daan Ceelen,Wouter Ouwerkerk,Jasper Tromp,Jasper Tromp,Sylwia M. Figarska,Stefan D. Anker,Kenneth Dickstein,Kenneth Dickstein,Gerasimos Filippatos,Gerasimos Filippatos,Faiez Zannad,Metra Marco,Leong L. Ng,Nilesh J. Samani,Dirk J. van Veldhuisen,Chim C. Lang,Carolyn S.P. Lam,Carolyn S.P. Lam,Adriaan A. Voors +19 more
TL;DR: In this paper, the authors performed an unsupervised cluster analysis using 363 biomarkers from 429 patients with heart failure with preserved ejection fraction (HFpEF) and identified four distinct patient subgroups based on their biomarker profiles: cluster 1 with the highest prevalence of diabetes mellitus and renal disease; cluster 2 with oldest age and frequent age-related comorbidities; cluster 3 with youngest age, largest body size, least symptoms and lowest N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels.