N
Nilesh J. Samani
Researcher at University of Leicester
Publications - 836
Citations - 127518
Nilesh J. Samani is an academic researcher from University of Leicester. The author has contributed to research in topics: Genome-wide association study & Population. The author has an hindex of 149, co-authored 779 publications receiving 113545 citations. Previous affiliations of Nilesh J. Samani include University Hospitals of Leicester NHS Trust & Glenfield Hospital.
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Journal ArticleDOI
Concentric vs. eccentric remodelling in heart failure with reduced ejection fraction: clinical characteristics, pathophysiology and response to treatment
Jan F. Nauta,Yoran M. Hummel,Jasper Tromp,Wouter Ouwerkerk,Peter van der Meer,Xuanyi Jin,Carolyn S.P. Lam,Jeroen J. Bax,Marco Metra,Nilesh J. Samani,Nilesh J. Samani,Piotr Ponikowski,Kenneth Dickstein,Kenneth Dickstein,Stefan D. Anker,Chim C. Lang,Leong L. Ng,Leong L. Ng,Faiez Zannad,Gerasimos Filippatos,Gerasimos Filippatos,Dirk J. van Veldhuisen,Joost P. van Melle,Adriaan A. Voors +23 more
TL;DR: Clinical characteristics, biomarker patterns, and response to treatment of patients with HFrEF and eccentric vs. concentric LV hypertrophy are compared.
Journal ArticleDOI
Exome-chip meta-analysis identifies novel loci associated with cardiac conduction, including ADAMTS6
Bram P. Prins,Bram P. Prins,Timothy J. Mead,Jennifer A. Brody,Gardar Sveinbjornsson,Ioanna Ntalla,Nathan A. Bihlmeyer,Marten E. van den Berg,Jette Bork-Jensen,Stefania Cappellani,Stefan van Duijvenboden,Stefan van Duijvenboden,Nikolai Klena,George C. Gabriel,Xiaoqin Liu,Çağrı Güleç,Niels Grarup,Jeffrey Haessler,Leanne M. Hall,Leanne M. Hall,Annamaria Iorio,Aaron Isaacs,Aaron Isaacs,Ruifang Li-Gao,Honghuang Lin,Ching-Ti Liu,Leo-Pekka Lyytikäinen,Jonathan Marten,Hao Mei,Martina Müller-Nurasyid,Michele Orini,Sandosh Padmanabhan,Farid Radmanesh,Farid Radmanesh,Julia Ramirez,Antonietta Robino,Molly Schwartz,Jessica van Setten,Albert V. Smith,Niek Verweij,Niek Verweij,Niek Verweij,Helen R. Warren,Stefan Weiss,Alvaro Alonso,David O Arnar,Michiel L. Bots,Rudolf A. de Boer,Anna F. Dominiczak,Mark Eijgelsheim,Patrick T. Ellinor,Xiuqing Guo,Xiuqing Guo,Stephan B. Felix,Tamara B. Harris,Caroline Hayward,Susan R. Heckbert,Paul L. Huang,Joop Jukema,Mika Kähönen,Jan A. Kors,Pier D. Lambiase,Lenore J. Launer,Man Li,Allan Linneberg,Christopher P. Nelson,Christopher P. Nelson,Oluf Pedersen,Marco V Perez,Annette Peters,Ozren Polasek,Bruce M. Psaty,Bruce M. Psaty,Olli T. Raitakari,Kenneth Rice,Jerome I. Rotter,Moritz F. Sinner,Elsayed Z. Soliman,Tim D. Spector,Konstantin Strauch,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Andrew Tinker,Stella Trompet,André G. Uitterlinden,Ilonca Vaartjes,Peter van der Meer,Uwe Völker,Henry Völzke,Melanie Waldenberger,James G. Wilson,Zhijun Xie,Folkert W. Asselbergs,Marcus Dörr,Cornelia M. van Duijn,Paolo Gasparini,Paolo Gasparini,Daniel F. Gudbjartsson,Daniel F. Gudbjartsson,Vilmundur Gudnason,Torben Hansen,Stefan Kääb,Jørgen K. Kanters,Charles Kooperberg,Terho Lehtimäki,Henry J. Lin,Henry J. Lin,Steven A. Lubitz,Dennis O. Mook-Kanamori,Francesco J. Conti,Christopher Newton-Cheh,Christopher Newton-Cheh,Jonathan Rosand,Jonathan Rosand,Igor Rudan,Nilesh J. Samani,Nilesh J. Samani,Gianfranco Sinagra,Blair H. Smith,Hilma Holm,Bruno H. Stricker,Sheila Ulivi,Nona Sotoodehnia,Suneel S. Apte,Pim van der Harst,Kari Stefansson,Kari Stefansson,Patricia B. Munroe,Dan E. Arking,Cecilia W. Lo,Yalda Jamshidi +130 more
TL;DR: Putative functional coding variation associated with changes in the QRS interval duration is identified by combining Illumina HumanExome BeadChip genotype data from 77,898 participants of European ancestry and 7695 of African descent in the discovery cohort, followed by replication in 111,874 individuals from the UK Biobank and deCODE cohorts.
Journal ArticleDOI
New Blood Pressure-Associated Loci Identified in Meta-Analyses of 475 000 Individuals
Aldi T. Kraja,James P. Cook,Helen R. Warren,Praveen Surendran,Chunyu Liu,Evangelos Evangelou,Evangelos Evangelou,Alisa K. Manning,Alisa K. Manning,Niels Grarup,Fotios Drenos,Fotios Drenos,Xueling Sim,Xueling Sim,Albert V. Smith,Najaf Amin,Alexandra I. F. Blakemore,Alexandra I. F. Blakemore,Jette Bork-Jensen,Ivan Brandslund,Aliki-Eleni Farmaki,Cristiano Fava,Teresa Ferreira,Karl-Heinz Herzig,Karl-Heinz Herzig,Karl-Heinz Herzig,Ayush Giri,Franco Giulianini,Megan L. Grove,Xiuqing Guo,Sarah E. Harris,Christian Theil Have,Aki S. Havulinna,He Zhang,Marit E. Jørgensen,Anne Mari Käräjämäki,Charles Kooperberg,Allan Linneberg,Louis Little,Yongmei Liu,Lori L. Bonnycastle,Yingchang Lu,Yingchang Lu,Reedik Mägi,Anubha Mahajan,Giovanni Malerba,Riccardo E. Marioni,Hao Mei,Cristina Menni,Alanna C. Morrison,Sandosh Padmanabhan,Walter Palmas,Alaitz Poveda,Rainer Rauramaa,Nigel W. Rayner,Nigel W. Rayner,Nigel W. Rayner,Muhammad Riaz,Kenneth Rice,Melissa A. Richard,Jennifer A. Smith,Lorraine Southam,Lorraine Southam,Alena Stančáková,Kathleen Stirrups,Kathleen Stirrups,Vinicius Tragante,Tiinamaija Tuomi,Ioanna Tzoulaki,Ioanna Tzoulaki,Tibor V. Varga,Stefan Weiss,Andrianos M. Yiorkas,Andrianos M. Yiorkas,Robin Young,Weihua Zhang,Weihua Zhang,Michael R. Barnes,Claudia P. Cabrera,He Gao,Michael Boehnke,Eric Boerwinkle,Eric Boerwinkle,John C. Chambers,John C. Chambers,John M. C. Connell,John M. C. Connell,Cramer Christensen,Rudolf A. de Boer,Ian J. Deary,George Dedoussis,Panos Deloukas,Anna F. Dominiczak,Marcus Dörr,Roby Joehanes,Todd L. Edwards,Tõnu Esko,Myriam Fornage,Nora Franceschini,Paul W. Franks,Paul W. Franks,Giovanni Gambaro,Leif Groop,Göran Hallmans,Torben Hansen,Caroline Hayward,Oksa Heikki,Erik Ingelsson,Erik Ingelsson,Jaakko Tuomilehto,Marjo-Riitta Järvelin,Marjo-Riitta Järvelin,Sharon L.R. Kardia,Fredrik Karpe,Jaspal S. Kooner,Jaspal S. Kooner,Jaspal S. Kooner,Timo A. Lakka,Claudia Langenberg,Lars Lind,Ruth J. F. Loos,Markku Laakso,Mark I. McCarthy,Mark I. McCarthy,Olle Melander,Karen L. Mohlke,Andrew P. Morris,Colin N. A. Palmer,Oluf Pedersen,Ozren Polasek,Neil Poulter,Michael A. Province,Bruce M. Psaty,Bruce M. Psaty,Paul M. Ridker,Paul M. Ridker,Paul M. Ridker,Jerome I. Rotter,Igor Rudan,Veikko Salomaa,Nilesh J. Samani,Peter S. Sever,Tea Skaaby,Jeanette M. Stafford,John M. Starr,Pim van der Harst,Peter van der Meer,Cornelia M. van Duijn,Anne-Claire Vergnaud,Vilmundur Gudnason,Nicholas J. Wareham,James G. Wilson,Cristen J. Willer,Daniel R. Witte,Eleftheria Zeggini,Danish Saleheen,Danish Saleheen,Adam S. Butterworth,John Danesh,John Danesh,Folkert W. Asselbergs,Folkert W. Asselbergs,Louise V. Wain,Georg Ehret,Georg Ehret,Daniel I. Chasman,Daniel I. Chasman,Daniel I. Chasman,Mark J. Caulfield,Paul Elliott,Cecilia M. Lindgren,Cecilia M. Lindgren,Cecilia M. Lindgren,Daniel Levy,Christopher Newton-Cheh,Christopher Newton-Cheh,Patricia B. Munroe,Joanna M. M. Howson +177 more
TL;DR: This analysis highlights several candidate genes with variation that alter protein function or gene expression for potential follow-up in BP and identifies 4 novel loci associated with BP regulation, and 1 independent variant at an established BP locus.
Journal ArticleDOI
Coding Variation in ANGPTL4, LPL, and SVEP1 and the Risk of Coronary Disease (vol 374, pg 1134, 2016)
Nathan O. Stitziel,Kathleen Stirrups,Nicholas G. D. Masca,Jeanette Erdmann,Paola G. Ferrario,Inke R. Koenig,Peter Weeke,Tom R. Webb,Paul L. Auer,Ursula M. Schick,Yingchang Lu,He Zhang,Marie-Pierre Dubé,Anuj Goel,Martin Farrall,Gina M. Peloso,Hong-Hee Won,Ron Do,Erik P A Van Iperen,Stavroula Kanoni,Jochen Kruppa,Anubha Mahajan,Robert A. Scott,Christina Willenborg,Peter S. Braund,Julian C. van Capelleveen,Alex S. F. Doney,Louise A. Donnelly,Rosanna Asselta,Piera Angelica Merlini,Stefano Duga,Nicola Marziliano,Josh C. Denny,Christian M. Shaffer,Nour Eddine El-Mokhtari,Andre Franke,Omri Gottesman,Stefanie Heilmann,Christian Hengstenberg,Per Hoffmann,Oddgeir L. Holmen,Kristian Hveem,Jan-Håkan Jansson,Karl-Heinz Joeckel,Thorsten Kessler,Jennifer Kriebel,Karl L. Laugwitz,Eirini Marouli,Nicola Martinelli,Mark I. McCarthy,Natalie R. van Zuydam,Christa Meisinger,Tõnu Esko,Evelin Mihailov,Stefan A. Escher,Maris Alver,Susanne Moebus,Andrew D. Morris,Martina Müller-Nurasyid,Majid Nikpay,Oliviero Olivieri,Louis-Philippe Lemieux Perreault,Alaa AlQarawi,Neil Robertson,Karen O. Akinsanya,Dermot F. Reilly,Thomas F. Vogt,Wu Yin,Folkert W. Asselbergs,Charles Kooperberg,Rebecca D. Jackson,Eli A. Stahl,Konstantin Strauch,Tibor V. Varga,Melanie Waldenberger,Lingyao Zeng,Aldi T. Kraja,Chunyu Liu,Georg Ehret,Christopher Newton-Cheh,Daniel I. Chasman,Rajiv Chowdhury,Marco M Ferrario,Ian Ford,J. Wouter Jukema,Frank Kee,Kari Kuulasmaa,Børge G. Nordestgaard,Markus Perola,Danish Saleheen,Naveed Sattar,Praveen Surendran,David-Alexandre Trégouët,Robin Young,Joanna M. M. Howson,Adam S. Butterworth,John Danesh,Diego Ardissino,Erwin P. Bottinger,Raimund Erbel,Paul W. Franks,Domenico Girelli,Alistair S. Hall,G. Kees Hovingh,Adnan Kastrati,Wolfgang Lieb,Thomas Meitinger,William E. Kraus,Svati H. Shah,Ruth McPherson,Marju Orho-Melander,Olle Melander,Andres Metspalu,Colin N. A. Palmer,Annette Peters,Daniel J. Rader,Muredach P. Reilly,Ruth J. F. Loos,Alex P. Reiner,Dan M. Roden,Jean-Claude Tardif,John Thompson,Nicholas J. Wareham,Hugh Watkins,Cristen J. Willer,Sekar Kathiresan,Panos Deloukas,Nilesh J. Samani,Heribert Schunkert +128 more
Journal ArticleDOI
Comparing biomarker profiles of patients with heart failure: atrial fibrillation vs. sinus rhythm and reduced vs. preserved ejection fraction
Bernadet T. Santema,Mariëlle Kloosterman,Isabelle C. Van Gelder,Ify R. Mordi,Chim C. Lang,Carolyn S.P. Lam,Stefan D. Anker,John G.F. Cleland,John G.F. Cleland,Kenneth Dickstein,Kenneth Dickstein,Gerasimos Filippatos,Pim van der Harst,Hans L. Hillege,Jozine M. ter Maaten,Marco Metra,Leong L. Ng,Leong L. Ng,Piotr Ponikowski,Nilesh J. Samani,Nilesh J. Samani,Dirk J. van Veldhuisen,Aeilko H. Zwinderman,Faiez Zannad,Kevin Damman,Peter van der Meer,Michiel Rienstra,Adriaan A. Voors +27 more
TL;DR: In patients with HFrEF, the presence of AF was associated with a homogeneously elevated cardiovascular risk marker profile, suggesting differences in underlying pathophysiological mechanisms of AF in these HF phenotypes, compared with patients with HFpEF.