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Nilesh J. Samani
Researcher at University of Leicester
Publications - 836
Citations - 127518
Nilesh J. Samani is an academic researcher from University of Leicester. The author has contributed to research in topics: Genome-wide association study & Population. The author has an hindex of 149, co-authored 779 publications receiving 113545 citations. Previous affiliations of Nilesh J. Samani include University Hospitals of Leicester NHS Trust & Glenfield Hospital.
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Protein-Truncating Variants at the Cholesteryl Ester Transfer Protein Gene and Risk for Coronary Heart DiseaseNovelty and Significance
Akihiro Nomura,Hong-Hee Won,Amit Khera,Fumihiko Takeuchi,Kaoru Ito,Shane McCarthy,Connor A. Emdin,Derek Klarin,Pradeep Natarajan,Namrata Gupta,Gina M. Peloso,Ingrid B. Borecki,Tanya M. Teslovich,Rosanna Asselta,Stefano Duga,Piera Angelica Merlini,Adolfo Correa,Thorsten Kessler,James G. Wilson,Matthew J. Bown,Alistair S. Hall,Peter S. Braund,David J. Carey,H. Lester Kirchner,Joseph B. Leader,Daniel R. Lavage,J. Neil Manus,Dustin N. Hartze,Nilesh J. Samani,Heribert Schunkert,Jaume Marrugat,Roberto Elosua,Ruth McPherson,Martin Farrall,Hugh Watkins,Jyh-Ming Jimmy Juang,Chao A. Hsiung,Shih-Yi Lin,Jun-Sing Wang,Hayato Tada,Masa-aki Kawashiri,Akihiro Inazu,Masakazu Yamagishi,Tomohiro Katsuya,Eitaro Nakashima,Masahiro Nakatochi,Ken Yamamoto,Mitsuhiro Yokota,Yukihide Momozawa,Jerome I. Rotter,Daniel J. Rader,John Danesh,Diego Ardissino,Stacey Gabriel,Cristen J. Willer,Gonçalo R. Abecasis,Danish Saleheen,Michiaki Kubo,Norihiro Kato,Yii-Der Ida Chen,Frederick E. Dewey,Sekar Kathiresan,Seyedeh M. Zekavat,Michael F. Murray,Eric S. Lander +64 more
TL;DR: CETP PTV carrier status was associated with reduced risk for CHD and, compared with noncarriers, carriers of PTV at CETP displayed higher high-density lipoprotein cholesterol, lower low-density lipid levels, lower triglycerides, and lower risk forCHD.
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Biomarker-Guided Versus Guideline-Based Treatment of Patients With Heart Failure: Results From BIOSTAT-CHF
Wouter Ouwerkerk,Wouter Ouwerkerk,Aeilko H. Zwinderman,Leong L. Ng,Biniyam G. Demissei,Hans L. Hillege,Faiez Zannad,Dirk J. van Veldhuisen,Nilesh J. Samani,Piotr Ponikowski,Marco Metra,Jozine M. ter Maaten,Chim C. Lang,Pim van der Harst,Gerasimos Filippatos,Kenneth Dickstein,John G.F. Cleland,Stefan D. Anker,Adriaan A. Voors +18 more
TL;DR: Up-titrating patients with heart failure based on biomarker values might have resulted in fewer deaths or hospitalizations compared with a hypothetical scenario in which all patients were successfully up-Titrated.
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Expression quantitative trait Loci acting across multiple tissues are enriched in inherited risk for coronary artery disease.
Hassan Foroughi Asl,Husain A. Talukdar,Alida S.D. Kindt,Rajeev K. Jain,Raili Ermel,Arno Ruusalepp,Khanh-Dung H. Nguyen,Radu Dobrin,Dermot F. Reilly,Heribert Schunkert,Nilesh J. Samani,Ingrid Braenne,Jeanette Erdmann,Olle Melander,Jianlong Qi,Torbjörn Ivert,Josefin Skogsberg,Eric E. Schadt,Tom Michoel,Johan L.M. Björkegren +19 more
TL;DR: eQTLs acting across multiple tissues are significant carriers of inherited risk for CAD and FLYWCH1, PSORSIC3, and G3BP1 are novel master regulatory genes in CAD that may be suitable targets.
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The prothrombin 20210A allele and its association with myocardial infarction.
S. A. Croft,Martina E. Daly,Richard P. Steeds,Kevin S Channer,Nilesh J. Samani,K. K. Hampton +5 more
TL;DR: The PT20210A allele is not a risk factor for MI and it is suggested that discrepancies in studies relating the PT202 10A allele to MI may be due to difficulties in estimating its low allelic frequency in the general population and thus random differences in the observed frequencies in the control populations studied.
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Uncovering genetic mechanisms of kidney aging through transcriptomics, genomics, and epigenomics
Joshua Rowland,Artur Akbarov,James Eales,Xiaoguang Xu,John Dormer,Hui Guo,Matthew Denniff,Xiao Jiang,Parisa Ranjzad,Alicja Nazgiewicz,Priscilla R. Prestes,Andrzej Antczak,Monika Szulińska,Ingrid Wise,Ewa Zukowska-Szczechowska,Paweł Bogdański,Adrian S. Woolf,Nilesh J. Samani,Fadi J. Charchar,Maciej Tomaszewski,Maciej Tomaszewski +20 more
TL;DR: Robust molecular signatures of the aging kidney and new regulatory mechanisms of age-related change in the kidney transcriptome are revealed.