N
Nilesh J. Samani
Researcher at University of Leicester
Publications - 836
Citations - 127518
Nilesh J. Samani is an academic researcher from University of Leicester. The author has contributed to research in topics: Genome-wide association study & Population. The author has an hindex of 149, co-authored 779 publications receiving 113545 citations. Previous affiliations of Nilesh J. Samani include University Hospitals of Leicester NHS Trust & Glenfield Hospital.
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Journal ArticleDOI
Loss of cardioprotective effects at the ADAMTS7 locus as a result of gene-smoking interactions
Danish Saleheen,Wei Zhao,Robin Young,Christopher P. Nelson,WeangKee Ho,Jane F. Ferguson,Jane F. Ferguson,Asif Rasheed,Kristy Ou,Sylvia T. Nurnberg,Sylvia T. Nurnberg,Robert C. Bauer,Robert C. Bauer,Anuj Goel,Ron Do,Ron Do,Alexandre F.R. Stewart,Alexandre F.R. Stewart,Jaana Hartiala,Jaana Hartiala,Weihua Zhang,Gudmar Thorleifsson,Rona J. Strawbridge,Rona J. Strawbridge,Juha Sinisalo,Stavroula Kanoni,Stavroula Kanoni,Sanaz Sedaghat,Eirini Marouli,Eirini Marouli,K. Kristiansson,K. Kristiansson,Jing Hua Zhao,Jing Hua Zhao,Robert A. Scott,Dominique Gauguier,Dominique Gauguier,Svati H. Shah,Svati H. Shah,Albert V. Smith,Natalie van Zuydam,Amanda J. Cox,Christina Willenborg,Christina Willenborg,Christina Willenborg,Thorsten Kessler,Lingyao Zeng,Michael A. Province,Andrea Ganna,Lars Lind,Nancy L. Pedersen,Charles C. White,Anni Joensuu,Marcus Edi Kleber,Alistair S. Hall,Winfried März,Veikko Salomaa,Christopher J. O'Donnell,Erik Ingelsson,Mary F. Feitosa,Jeanette Erdmann,Donald W. Bowden,Donald W. Bowden,Colin N. A. Palmer,Colin N. A. Palmer,Vilmundur Gudnason,Ulf de Faire,Pierre Zalloua,Nicholas J. Wareham,John Thompson,Kari Kuulasmaa,George V. Dedoussis,George V. Dedoussis,Markus Perola,Abbas Dehghan,John C. Chambers,John C. Chambers,Jaspal S. Kooner,Hooman Allayee,Panos Deloukas,Ruth McPherson,Ruth McPherson,K. Stefansson,Heribert Schunkert,Sekar Kathiresan,Sekar Kathiresan,Martin Farrall,Philippe M. Frossard,Daniel J. Rader,Nilesh J. Samani,Muredach P. Reilly +90 more
TL;DR: In this paper, the interaction of genetic susceptibility with lifestyle factors may play a prominent role in coronary heart disease (CHD) etiology and the interaction between genetic susceptibility and lifestyle factors is discussed.
Journal ArticleDOI
Chromosome 2p Shows Significant Linkage to Antihypertensive Response in the British Genetics of Hypertension Study
Sandosh Padmanabhan,Chris Wallace,Patricia B. Munroe,Richard Dobson,Morris J. Brown,Nilesh J. Samani,David Clayton,Martin Farrall,John Webster,Mark Lathrop,Mark J. Caulfield,Anna F. Dominiczak,John M. C. Connell +12 more
TL;DR: This work has demonstrated for the first time identification of a significant locus by partitioning different pathways of hypertension using drug response and enhances gene finding in the British Genetics of Hypertension Study population.
Journal ArticleDOI
Spontaneous Coronary Artery Dissection: Insights on Rare Genetic Variation From Genome Sequencing.
Keren J Carss,Anna A Baranowska,Javier Armisen,Tom R. Webb,Stephen E. Hamby,Diluka Premawardhana,Abtehale Al-Hussaini,Alice Wood,Quanli Wang,Sri V V Deevi,Dimitrios Vitsios,Samuel H. Lewis,Deevia Kotecha,Nabila Bouatia-Naji,S. Hesselson,Siiri E. Iismaa,Siiri E. Iismaa,Ingrid S. Tarr,Lucy McGrath-Cadell,David W.M. Muller,David W.M. Muller,Sally L. Dunwoodie,Sally L. Dunwoodie,Diane Fatkin,Diane Fatkin,Diane Fatkin,Robert M. Graham,Robert M. Graham,Eleni Giannoulatou,Eleni Giannoulatou,Nilesh J. Samani,Slavé Petrovski,Carolina Haefliger,David Adlam +33 more
TL;DR: By studying the largest sequenced cohort of SCAD survivors, this work demonstrates that, based on current knowledge, only a small proportion of patients have a pathogenic variant that could explain their disease.
Journal ArticleDOI
A pharmacogenetic approach to blood pressure in Lyon hypertensive rats. A chromosome 2 locus influences the response to a calcium antagonist.
Madeleine Vincent,Nilesh J. Samani,Dominique Gauguier,John R. Thompson,G.M. Lathrop,Jean Sassard +5 more
TL;DR: Findings provide strong direct support for the paradigm that genetic factors may influence the response to antihypertensive drugs and suggest that the heterogeneity seen in the responses to different anti Hypertensive agents in human essential hypertension may have a significant genetic determination.
Journal ArticleDOI
VEGF-B-Neuropilin-1 signaling is spatiotemporally indispensable for vascular and neuronal development in zebrafish.
Lasse Jensen,Lasse Jensen,Masaki Nakamura,Lars Bräutigam,Xuri Li,Yizhi Liu,Nilesh J. Samani,Yihai Cao,Yihai Cao,Yihai Cao +9 more
TL;DR: It is shown that VEGF-B is spatiotemporally required for vascular development in zebrafish embryos and that NRP1, but not VEGFR1, mediates the essential signaling.