Ning Leng

TL;DR: EBSeq is developed, using the merits of empirical Bayesian methods, for identifying DE isoforms in an RNA-seq experiment comparing two or more biological conditions and proves to be a robust approach for identifying De genes.

TL;DR: Atezolizumab was not associated with significantly longer overall survival than chemotherapy in patients with platinum-refractory metastatic urothelial carcinoma overexpressing PD-L1, thus precluding further formal statistical analysis.

TL;DR: It is demonstrated that KLF8 plays a pivotal role modulating mesendoderm to DE differentiation, and the strategy of combining single-cell analysis and genetic approaches can be applied to uncover novel regulators governing cell fate decisions in a variety of systems.

TL;DR: SCnorm is introduced for accurate and efficient normalization of single-cell RNA-seq data and addresses the problem of artifacts that bias downstream analyses.

TL;DR: Integrated multi-omics evaluation of 823 tumors from advanced renal cell carcinoma patients identifies molecular subsets associated with differential clinical outcomes to angiogenesis blockade alone or with a checkpoint inhibitor that can be applied to molecularly stratify patients, explain improved outcomes of sarcomatoid tumors to checkpoint blockade versus antiangiogenics alone, and develop personalized therapies in RCC and other indications.