N
Nirzari Gupta
Researcher at University of Alabama at Birmingham
Publications - 21
Citations - 304
Nirzari Gupta is an academic researcher from University of Alabama at Birmingham. The author has contributed to research in topics: Docking (molecular) & Metastasis. The author has an hindex of 9, co-authored 21 publications receiving 207 citations. Previous affiliations of Nirzari Gupta include Nirma University of Science and Technology.
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Journal ArticleDOI
Honokiol inhibits the growth of head and neck squamous cell carcinoma by targeting epidermal growth factor receptor
Tripti Singh,Nirzari Gupta,Su Xu,Ram Prasad,Sadanandan E. Velu,Santosh K. Katiyar,Santosh K. Katiyar +6 more
TL;DR: Molecular docking analysis of honokiol in EGFR binding site indicated that the chemotherapeutic effect of Honokiol against HNSCC is mediated through its firm binding with EGFR, which is better than that of gefitinib, a commonly used drug for H NSCC treatment.
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Manganoporphyrin-Polyphenol Multilayer Capsules as Radical and Reactive Oxygen Species (ROS) Scavengers
Aaron Alford,Veronika Kozlovskaya,Bing Xue,Nirzari Gupta,William Higgins,Dana Pham-Hua,Lilin He,Volker S. Urban,Hubert M. Tse,Eugenia Kharlampieva +9 more
TL;DR: A synergistic manganoporphyrin-polyphenol polymeric nanothin coating and hollow microcapsules with efficient antioxidant activity and controllable ROS modulation is developed to mediate natural and synthetic antioxidants with limited capability to scavenge reactive oxygen species.
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Design, synthesis and docking studies of some novel (R)-2-(4'-chlorophenyl)-3-(4'-nitrophenyl)-1,2,3,5-tetrahydrobenzo[4,5] imidazo [1,2-c]pyrimidin-4-ol derivatives as antitubercular agents.
Kuldipsinh P. Barot,Shailesh V. Jain,Nirzari Gupta,Laurent Kremer,Laurent Kremer,Shubhra Singh,Shubhra Singh,Shubhra Singh,Vijay Takale,Kruti Joshi,Manjunath Ghate +10 more
TL;DR: Assays for in vitro cytotoxicity against VERO cells of all the synthesized compounds was found to be very less cytotoxic and validated with in Vitro antitubercular activity of compound 7t.
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Targeting P4HA1 with a Small Molecule Inhibitor in a Colorectal Cancer PDX Model.
Sumit Agarwal,Michael Behring,Hyung-Gyoon Kim,Prachi Bajpai,Balabhadrapatruni V. S. K. Chakravarthi,Nirzari Gupta,Amr Elkholy,Sameer Al Diffalha,Sooryanarayana Varambally,Upender Manne +9 more
TL;DR: The present study shows that P4HA1 contributes to CRC progression and metastasis and that targeting of P 4HA1 with diethyl-pythiDC could be an effective therapeutic strategy for aggressive CRCs.
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PAICS, a Purine Nucleotide Metabolic Enzyme, is Involved in Tumor Growth and the Metastasis of Colorectal Cancer.
Sumit Agarwal,Balabhadrapatruni V. S. K. Chakravarthi,Michael Behring,Hyung-Gyoon Kim,Darshan S. Chandrashekar,Nirzari Gupta,Prachi Bajpai,Amr Elkholy,Sai Akshaya Hodigere Balasubramanya,Cherlene Y. Hardy,Sameer Al Diffalha,Sooryanarayana Varambally,Upender Manne +12 more
TL;DR: Overall, the findings point to the usefulness of PAICS targeting in the treatment of aggressive colorectal cancer.