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Nisc Comparative Sequencing Program
Researcher at National Institutes of Health
Publications - 97
Citations - 12555
Nisc Comparative Sequencing Program is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Gene & Exome sequencing. The author has an hindex of 41, co-authored 96 publications receiving 10949 citations. Previous affiliations of Nisc Comparative Sequencing Program include University of California, San Diego & Emory University.
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Journal ArticleDOI
Topographical and temporal diversity of the human skin microbiome.
Elizabeth A. Grice,Heidi H. Kong,Sean Conlan,Clayton Deming,Joie Davis,Alice C. Young,Nisc Comparative Sequencing Program,Gerard G. Bouffard,Robert W. Blakesley,Patrick R. Murray,Eric D. Green,Maria L. Turner,Julia A. Segre +12 more
TL;DR: This topographical and temporal survey of body sites from 10 healthy human individuals sampled over time provides a baseline for studies that examine the role of bacterial communities in disease states and the microbial interdependencies required to maintain healthy skin.
Journal ArticleDOI
LAGAN and Multi-LAGAN: efficient tools for large-scale multiple alignment of genomic DNA.
Michael Brudno,Chuong B. Do,Gregory M. Cooper,Michael F. Kim,Eugene Davydov,Nisc Comparative Sequencing Program,Eric D. Green,Arend Sidow,Serafim Batzoglou +8 more
TL;DR: Both LAGAN and Multi-LAGAN compare favorably with other leading alignment methods in correctly aligning protein-coding exons, especially between distant homologs such as human and chicken, or human and fugu.
Journal ArticleDOI
Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus
Hua-Xin Liao,Rebecca M. Lynch,Tongqing Zhou,Feng Gao,Feng Gao,S. Munir Alam,S. Munir Alam,Scott D. Boyd,Andrew Fire,Krishna M. Roskin,Chaim A. Schramm,Zhenhai Zhang,Jiang Zhu,Lawrence Shapiro,Lawrence Shapiro,Nisc Comparative Sequencing Program,James C. Mullikin,Sandrasegaram Gnanakaran,Peter T. Hraber,Kevin Wiehe,Kevin Wiehe,Garnett Kelsoe,Garnett Kelsoe,Guang Yang,Guang Yang,Shi-Mao Xia,Shi-Mao Xia,David C. Montefiori,David C. Montefiori,Robert Parks,Robert Parks,Krissey E. Lloyd,Krissey E. Lloyd,Richard M. Scearce,Richard M. Scearce,Kelly A. Soderberg,Kelly A. Soderberg,Myron S. Cohen,Gift Kamanga,Mark K. Louder,Lillian Tran,Yue Chen,Yue Chen,Fangping Cai,Fangping Cai,Sheri Chen,Sheri Chen,Stephanie Moquin,Xiulian Du,M. Gordon Joyce,Sanjay Srivatsan,Baoshan Zhang,Anqi Zheng,George M. Shaw,Beatrice H. Hahn,Thomas B. Kepler,Bette T. Korber,Peter D. Kwong,John R. Mascola,Barton F. Haynes,Barton F. Haynes +60 more
TL;DR: The isolation, evolution and structure of a broadly neutralizing antibody from an African donor followed from the time of infection and its co-crystal structure revealed a new loop-based mechanism of CD4-binding-site recognition.
Journal ArticleDOI
Biogeography and individuality shape function in the human skin metagenome
Julia Oh,Allyson L. Byrd,Clay Deming,Sean Conlan,Nisc Comparative Sequencing Program,Heidi H. Kong,Julia A. Segre +6 more
TL;DR: This work developed a relational analysis of bacterial, fungal and viral communities, which showed not only site specificity but also individual signatures, and identified strain-level variation of dominant species as heterogeneous and multiphyletic.
Journal ArticleDOI
Chromatin stretch enhancer states drive cell-specific gene regulation and harbor human disease risk variants
Stephen C. J. Parker,Michael L. Stitzel,D. Leland Taylor,Jose M. Orozco,Michael R. Erdos,Jennifer A. Akiyama,Kelly Lammerts van Bueren,Peter S. Chines,Narisu Narisu,Nisc Comparative Sequencing Program,Brian L. Black,Axel Visel,Axel Visel,Len A. Pennacchio,Len A. Pennacchio,Francis S. Collins,Jesse Becker,Betty Benjamin,Robert W. Blakesley,Gerry Bouffard,Shelise Brooks,Holly Coleman,Mila Dekhtyar,Michael D. Gregory,Xiaobin Guan,Jyoti Gupta,Joel Han,April Hargrove,Shi-ling Ho,Taccara Johnson,Richelle Legaspi,Sean Lovett,Quino Maduro,Cathy Masiello,Baishali Maskeri,Jenny McDowell,Casandra Montemayor,James C. Mullikin,Morgan Park,Nancy Riebow,Karen Schandler,Brian L. Schmidt,Christina Sison,Mal Stantripop,James Thomas,Pam Thomas,Meg Vemulapalli,Alice Young +47 more
TL;DR: In this article, the authors performed systematic chromatin and transcriptome profiling in human pancreatic islets and found that stretch enhancers are critical chromatin elements for coordinating cell type-specific regulatory programs.