Nita Aryanti

Bio: Nita Aryanti is an academic researcher from Diponegoro University. The author has contributed to research in topics: Membrane & Glucomannan. The author has an hindex of 13, co-authored 90 publications receiving 502 citations. Previous affiliations of Nita Aryanti include University of Leeds & University of Oviedo.

Modelling of controlled drug release in gastrointestinal tract simulation

Abstract: The drug release system is a process in which a bioactive substance discharged from a drug product and enters the process of absorption, distribution and metabolism to deliver its pharmacological action. The drug release is maintained at a specific rate to maximize the benefits as well as to suppress the side impacts. The release rate behaviour is affected by physiological conditions such as ion charge, pH level and enzymatic environment. Since the intestinal tract itself varies broadly in a pH environment, hence it is important to study the profile of drug release in different pH conditions. Mathematical model turns out very useful in predicting the drug release as well as reducing experimental works. The objective of this work was to study the mathematical model in describing the drug release profile in gastrointestinal tract liquid simulation. The release profiles of furosemide and sodium-iron chlorophyllin encapsulation were studied in the pH ranges 1.3-1.5 and 6.8-7.4 to simulate the different part of gastrointestinal tract acidity. The Korsemeyer-Peppas, Weibull and Gompertz were applied in describing the profile. Korsmeyer-Peppas model shows more superior (R2>0.912) than Weibull and Gompertz in describing the release kinetic of furosemide and sodium-iron chlorophyllin encapsulations in both pHs of GTS. The n values of Korsmeyer-Peppas are mostly less than 0.5 suggesting the release mechanism was governed by diffusion.

Lignin isolation process from rice husk by alkaline hydrogen peroxide: Lignin and silica extracted

Abstract: Biomass is one of abundance resources in the world. Biomass consists of three main materials such as cellulose, hemicelluloses and lignin. Therefore, biomass can be referred to lignocellulosic material. Both the cellulose and hemicelluloses fractions are polymers of sugars, and thereby a potential source of fermentable sugars, or other processes that convert sugars into products. Lignin is a polymer compound which contains of phenolic compounds. Rice husk is one of biomass, which has high contain of lignin. Rice husk has special characteristics because of silica content. The aim of this paper is to analyze lignin and silica extracted during lignin isolation process of rice husk using alkaline hydrogen peroxide. Three main variables such as solvent/solid ratio, concentration of hydrogen peroxide and pH of the mixture are studied. The optimum conditions for lignin isolation are at solvent/solid ratio 9:1 ml/gr, hydrogen peroxide concentration of 1.5%v and pH of the mixture of 11.

Produced water characteristics, treatment and reuse: A review

Abstract: In oil and gas industry, produced water is considered as the largest waste stream, which contains relatively higher concentration of hydrocarbons, heavy metals and other pollutants. Due to the increase in industrial activities, the generation of produced water has increased all over the world and its treatment for reuse is now important from environmental perspective. Treatment of produced water can be done through various methods including physical (membrane filtration, adsorption etc.), chemical (precipitation, oxidation), and biological (activated sludge, biological aerated filters and others) methods. This paper aims to highlight characteristics of produced water in detail and physical, chemical, and biological techniques used for its treatment. In addition, reuse of produced water for different purposes has been discussed. At the end, few case studies from different countries, related to the treatment and reuse of their produced waters have been included.

Production of uniform droplets using membrane, microchannel and microfluidic emulsification devices

Abstract: This review provides an overview of major microengineering emulsification techniques for production of monodispersed droplets. The main emphasis has been put on membrane emulsification using Shirasu Porous Glass and microsieve membrane, microchannel emulsification using grooved-type and straight-through microchannel plates, microfluidic junctions and flow focusing microfluidic devices. Microfabrication methods for production of planar and 3D poly(dimethylsiloxane) devices, glass capillary microfluidic devices and single-crystal silicon microchannel array devices have been described including soft lithography, glass capillary pulling and microforging, hot embossing, anisotropic wet etching and deep reactive ion etching. In addition, fabrication methods for SPG and microseive membranes have been outlined, such as spinodal decomposition, reactive ion etching and ultraviolet LIGA (Lithography, Electroplating, and Moulding) process. The most widespread application of micromachined emulsification devices is in the synthesis of monodispersed particles and vesicles, such as polymeric particles, microgels, solid lipid particles, Janus particles, and functional vesicles (liposomes, polymersomes and colloidosomes). Glass capillary microfluidic devices are very suitable for production of core/shell drops of controllable shell thickness and multiple emulsions containing a controlled number of inner droplets and/or inner droplets of two or more distinct phases. Microchannel emulsification is a very promising technique for production of monodispersed droplets with droplet throughputs of up to 100 l h−1.

Mathematical modeling of drug delivery from autocatalytically degradable PLGA microspheres — A review

Abstract: PLGA microspheres are widely studied for controlled release drug delivery applications, and many models have been proposed to describe PLGA degradation and erosion and drug release from the bulk polymer. Autocatalysis is known to have a complex role in the dynamics of PLGA erosion and drug transport and can lead to size-dependent heterogeneities in otherwise uniformly bulk-eroding polymer microspheres. The aim of this review is to highlight mechanistic, mathematical models for drug release from PLGA microspheres that specifically address interactions between phenomena generally attributed to autocatalytic hydrolysis and mass transfer limitation effects. Predictions of drug release profiles by mechanistic models are useful for understanding mechanisms and designing drug release particles.

Microfluidic Devices for Drug Delivery Systems and Drug Screening.

Abstract: Microfluidic devices present unique advantages for the development of efficient drug carrier particles, cell-free protein synthesis systems, and rapid techniques for direct drug screening. Compared to bulk methods, by efficiently controlling the geometries of the fabricated chip and the flow rates of multiphase fluids, microfluidic technology enables the generation of highly stable, uniform, monodispersed particles with higher encapsulation efficiency. Since the existing preclinical models are inefficient drug screens for predicting clinical outcomes, microfluidic platforms might offer a more rapid and cost-effective alternative. Compared to 2D cell culture systems and in vivo animal models, microfluidic 3D platforms mimic the in vivo cell systems in a simple, inexpensive manner, which allows high throughput and multiplexed drug screening at the cell, organ, and whole-body levels. In this review, the generation of appropriate drug or gene carriers including different particle types using different configurations of microfluidic devices is highlighted. Additionally, this paper discusses the emergence of fabricated microfluidic cell-free protein synthesis systems for potential use at point of care as well as cell-, organ-, and human-on-a-chip models as smart, sensitive, and reproducible platforms, allowing the investigation of the effects of drugs under conditions imitating the biological system.