Nithya Mariappan

TL;DR: A cardiopulmonary protective role for the ACE2/Ang-(1-7)/Mas axis in the treatment of lung disorders is demonstrated and blockade of the Mas receptor abolished the beneficial effects of Ang-1- 7 against MCT-induced PH.

TL;DR: This study demonstrates that NF-kappaB blockade with PDTC mitigates oxidative stress and improves mitochondrial structural integrity directly, through down-regulation of increased oxygen-free radicals, thereby increasing ATP synthesis and thus restoring cardiac function in type II diabetes.

TL;DR: Data indicate that long-term histone deacetylase inhibition, independent of the blood pressure response, reduces hypertrophic, proinflammatory, and hypertensive responses by decreasing reactive oxygen species and angiotensin II type1 receptor expression in the heart, demonstrating the importance of uncontrolled Histone de acetylase activity in hypertension.

TL;DR: The studies demonstrate that TNF-alpha-induced oxidative stress alters redox homeostasis by impairing the MPTP proteins adenine nucleotide translocator and voltage-dependent anion channel, thereby resulting in the pore opening, causing uncontrolled transport of substances to alter mitochondrial pH, and subsequently leading to dysfunction of mitochondria and attenuated cardiac function.

TL;DR: The important role that transcription factor NF&kgr;B plays within the PVN in modulating and perpetuating the hypertensive response via renin-angiotensin system modulation is demonstrated.