Author
Nobuaki Taniguchi
Other affiliations: Yale University, Baylor University
Bio: Nobuaki Taniguchi is an academic researcher from Tohoku University. The author has contributed to research in topics: Enantioselective synthesis & Michael reaction. The author has an hindex of 15, co-authored 64 publications receiving 539 citations. Previous affiliations of Nobuaki Taniguchi include Yale University & Baylor University.
Papers
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TL;DR: In this paper, the synthesis of chiral half esters via monosubstituted malonic CHs was studied and chiral 3-silyloxypropanols were enantioselectively synthesized.
Abstract: Syntheses of chiral synthons via monosubstituted malonic chiral half esters were studied and chiral 3-silyloxypropanols were enantioselectively synthesised.
TL;DR: In this article, the synthesis of chiral intermediates having one tertiary asymmetric center was carried out via chiral half-esters of monoalkylmalonic acids, and enantioselective preparation of unsymmetrical propane-1,3-diol derivatives was achieved by the use of 8-phenylmenthyl half-ester.
Abstract: Syntheses of chiral intermediates having one tertiary asymmetric centre were carried out via chiral half-esters of monoalkylmalonic acids. The menthyl half-ester of ethylmalonic acid afforded a single diastereoisomer through crystallisation-induced asymmetric transformation (second-order asymmetric transformation). Furthermore enantioselective preparation of unsymmetrical propane-1,3-diol derivatives was achieved by the use of 8-phenylmenthyl half-esters.
TL;DR: Fluorination of methyl (1R,3R,4S)-8-phenylmenthyl methylmalonates using lithium hexamethyl-disilazide and 1-fluoro-2,4,6-trimethylpyridinium triflate (trifluoromethanesulfonate) gave the (R)-3 and (S)-4 isomers in a 3.8 : 1 ratio, while fluorination of ethyl-, propyl- and benzyl-malonsates 10, 11 and 12 provided
Abstract: Fluorination of methyl (1R,3R,4S)-8-phenylmenthyl methylmalonates 2 using lithium hexamethyl-disilazide and 1-fluoro-2,4,6-trimethylpyridinium triflate (trifluoromethanesulfonate), gave the (R)-3 and (S)-4 isomers in a 3.8 : 1 ratio, while fluorination of ethyl-, propyl- and benzyl-malonates 10, 11 and 12 provided the (R)-13, 15 and 17 and (S)-14, 16 and 18 isomers in a 1 : 1.6–2.0 ratio. On the other hand, alkylation of (1R,3R,4S)-8-phenylmenthyl hydrogen fluoromalonates 26 in the presence of lithium hexamethyldisilazide, followed by esterification with diazomethane, produced the (R)-3,13,15,17- and 27 and (S)-4,14,16,18 and 28 isomers in a 1 : 5.7–35 ratio.
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11 Sep 2006TL;DR: It is shown that domino reactions initiated by oxidation or reduction or reduction, as well as other mechanisms, can be inhibited by various materials, such as Na6(CO3)(SO4), Na2SO4, Na2CO3, and so on.
Abstract: Introduction Cationic domino reactions Anionic domino reactions Radical domino reactions Pericyclic domino reactions Photochemically induced domino processes Transition metal catalysis Domino reactions initiated by oxidation or reduction Enzymes in domino reactions Multicomponent reactions Special techniques in domino reactions
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