Noomi Asker

TL;DR: The method was applicable also to newborn mice, which allows for the isolation of immature developmental stage glomeruli and makes feasible transcript profiling and proteomic analysis of the developing, healthy and diseased mouse glomerulus.

TL;DR: It is reported that endothelium‐restricted ablation of platelet‐derived growth factor‐B generates viable mice with extensive inter‐ and intra‐individual variation in the density of pericytes throughout the CNS, and a strong inverse correlation between pericyte density and the formation of a range of retinal microvascular abnormalities strongly reminiscent of those seen in diabetic humans.

TL;DR: An approach to identify pericyte markers based on transcription profiling of pericytedeficient brain microvessels isolated from platelet‐derived growth factor (PDGF‐B) and PDGFRβ mutant mice identifies novel markers for brain pericytes.

TL;DR: Pulse-chase experiments in the colon cell line LS 174T combined with subcellular fractionation by sucrose density gradient centrifugation and two-dimensional gel electrophoresis demonstrated that N-glycans of MUC2 are necessary for the correct folding and dimerization of the M UC2 mucin.

TL;DR: The results suggest that the MUC2 mucin is forming nonreducible intermolecular bonds early in biosynthesis, but after initial O-glycosylation.