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Noor Naemah Abdul Rahman

Bio: Noor Naemah Abdul Rahman is an academic researcher from University of Malaya. The author has contributed to research in topics: Medicine & Islam. The author has an hindex of 12, co-authored 65 publications receiving 471 citations. Previous affiliations of Noor Naemah Abdul Rahman include Schwind eye tech solutions & University of Karachi.


Papers
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Journal ArticleDOI
TL;DR: In vitro and in vivo validation is needed to study and develop an anti-COVID-19 drug based on the structures of the most promising compounds identified in this study.
Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused about 2 million infections and is responsible for more than 100,000 deaths worldwide. To date, there is no specific drug registered to combat the disease it causes, named coronavirus disease 2019 (COVID-19). In the current study, we used an in silico approach to screen natural compounds to find potent inhibitors of the host enzyme transmembrane protease serine 2 (TMPRSS2). This enzyme facilitates viral particle entry into host cells, and its inhibition blocks virus fusion with angiotensin-converting enzyme 2 (ACE2). This, in turn, restricts SARS-CoV-2 pathogenesis. A three-dimensional structure of TMPRSS2 was built using SWISS-MODEL and validated by RAMPAGE. The natural compounds library Natural Product Activity and Species Source (NPASS), containing 30,927 compounds, was screened against the target protein. Two techniques were used in the Molecular Operating Environment (MOE) for this purpose, i.e., a ligand-based pharmacophore approach and a molecular docking-based screening. In total, 2140 compounds with pharmacophoric features were retained using the first approach. Using the second approach, 85 compounds with molecular docking comparable to or greater than that of the standard inhibitor (camostat mesylate) were identified. The top 12 compounds with the most favorable structural features were studied for physicochemical and ADMET (absorption, distribution, metabolism, excretion, toxicity) properties. The low-molecular-weight compound NPC306344 showed significant interaction with the active site residues of TMPRSS2, with a binding energy score of -14.69. Further in vitro and in vivo validation is needed to study and develop an anti-COVID-19 drug based on the structures of the most promising compounds identified in this study.

134 citations

01 Aug 2008
TL;DR: A comprehensive review of Quran Arabic verse recitation recognition focusing on the techniques used, the advantages, and drawbacks is provided in this article, where areas with potential of further expansion are identified for future research for support in j-QAF learning.
Abstract: †Summary Each person’s voice is different. Thus, the Quran sound, which had been recited by most of recitors will probably tend to differ a lot from one person to another. Although those Quranic sentence were particularly taken from the same verse, but the way of the sentence in Al-Quran been recited or delivered may be different. It may produce the difference sounds for the different recitors. Those same combinations of letters may be pronounced differently due to the use of harakates. This paper seeks to provide a comprehensive review of Quran Arabic verse recitation recognition focusing on the techniques used, the advantages, and drawbacks. Areas with potential of further expansion are identified for future research for support in j-QAF learning.

50 citations

Journal ArticleDOI
28 Jul 2020-Vaccine
TL;DR: In conclusion, C1 was the best vaccine candidate among all designed constructs to elicit an immune response SARS-CoV-2 and combat the coronavirus disease (COVID-19).

45 citations

Journal ArticleDOI
TL;DR: This article looks at the framework of a complementary model of bioethics derived from the perspective of Islam based on ‘maqasid al-shariah’ (purposes or objectives of Islamic law), which aims to protect and preserve mankind’s faith, life, intellect, progeny, and property.
Abstract: With the rapid advancements made in biotechnology, bioethical discourse has become increasingly important. Bioethics is a multidisciplinary and interdisciplinary field that goes beyond the realm of natural sciences, and has involved fields in the domain of the social sciences. One of the important areas in bioethical discourse is religion. In a country like Malaysia, where Muslims make up the majority of the population, Islam plays a crucial role in providing the essential guidelines on the permissibility and acceptability of biotechnological applications in various fields such as medicine, agriculture, and food processing. This article looks at the framework of a complementary model of bioethics derived from the perspective of Islam. The framework is based on ‘maqasid al-shariah’ (purposes or objectives of Islamic law) which aims to protect and preserve mankind’s faith, life, intellect, progeny, and property. It is proposed that ‘maqasid al-shariah’ be used as a pragmatic checklist that can be utilized in tackling bioethical issues and dilemmas.

41 citations

Journal ArticleDOI
27 Sep 2019
TL;DR: The results revealed that nummularine-R and vindoline possess striking interactions with active site residues of the target protein, and were analogous to reference ligands, and provided a computational background to the α-glucosidase inhibitors tested.
Abstract: Diabetes mellitus, one of the most common endocrine-metabolic disorders, has caused significant morbidity and mortality worldwide. To avoid sugar digestion and postprandial hyperglycemia, it is necessary to inhibit α-glucosidase, a digestive enzyme with an important role in carbohydrate digestion. The criteria for the selection of alkaloids are based on their in vitro and in vivo activities on glucose modulation. The current study assessed the bonding potential of isolated alkaloids with the targeted protein. For this purpose, the 3D structure of the target protein (α-glucosidase) was reproduced using MODELLER 9.20. The modeled 3D structure was then validated and confirmed by using the RAMPAGE, ERRAT, and Verify3D online servers. The molecular docking of 32 alkaloids reported as α-glucosidase inhibitors, along with reference compounds (acarbose and miglitol), was done through MOE-Dock applied in MOE software to predict the binding modes of these drug-like compounds. The results revealed that nummularine-R and vindoline possess striking interactions with active site residues of the target protein, and were analogous to reference ligands. In conclusion, the current study provided a computational background to the α-glucosidase inhibitors tested. This novel information should facilitate the development of new and effective therapeutic compounds for the treatment of diabetes mellitus.

33 citations


Cited by
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Journal ArticleDOI
06 Jun 1986-JAMA
TL;DR: The editors have done a masterful job of weaving together the biologic, the behavioral, and the clinical sciences into a single tapestry in which everyone from the molecular biologist to the practicing psychiatrist can find and appreciate his or her own research.
Abstract: I have developed "tennis elbow" from lugging this book around the past four weeks, but it is worth the pain, the effort, and the aspirin. It is also worth the (relatively speaking) bargain price. Including appendixes, this book contains 894 pages of text. The entire panorama of the neural sciences is surveyed and examined, and it is comprehensive in its scope, from genomes to social behaviors. The editors explicitly state that the book is designed as "an introductory text for students of biology, behavior, and medicine," but it is hard to imagine any audience, interested in any fragment of neuroscience at any level of sophistication, that would not enjoy this book. The editors have done a masterful job of weaving together the biologic, the behavioral, and the clinical sciences into a single tapestry in which everyone from the molecular biologist to the practicing psychiatrist can find and appreciate his or

7,563 citations

01 Jul 2008
TL;DR: Results demonstrate a reliably quantifiable in vivo signature of abnormal cortical anatomy in AD, which parallels known regional vulnerability to AD neuropathology, and may provide a powerful methodological framework for studies of neuropsychiatric diseases.
Abstract: Alzheimer's disease (AD) is associated with neurodegeneration in vulnerable limbic and heteromodal regions of the cerebral cortex, detectable in vivo using magnetic resonance imaging. It is not clear whether abnormalities of cortical anatomy in AD can be reliably measured across different subject samples, how closely they track symptoms, and whether they are detectable prior to symptoms. An exploratory map of cortical thinning in mild AD was used to define regions of interest that were applied in a hypothesis-driven fashion to other subject samples. Results demonstrate a reliably quantifiable in vivo signature of abnormal cortical anatomy in AD, which parallels known regional vulnerability to AD neuropathology. Thinning in vulnerable cortical regions relates to symptom severity even in the earliest stages of clinical symptoms. Furthermore, subtle thinning is present in asymptomatic older controls with brain amyloid binding as detected with amyloid imaging. The reliability and clinical validity of AD-related cortical thinning suggests potential utility as an imaging biomarker. This “disease signature” approach to cortical morphometry, in which disease effects are mapped across the cortical mantle and then used to define ROIs for hypothesis-driven analyses, may provide a powerful methodological framework for studies of neuropsychiatric diseases.

673 citations

Journal ArticleDOI
TL;DR: This paper presents a new biometric authentication system using finger-knuckle-print (FKP) imaging, which achieves much higher recognition rate and it works in real time and has great potentials for commercial applications.

345 citations

Journal ArticleDOI
TL;DR: Flavonoids and their derivative may represent target compounds to be tested in future clinical trials to enrich the drug arsenal against coronavirus infections.

222 citations

Journal ArticleDOI
TL;DR: In this paper, up-to-date information on large tidal turbine projects over 500kW is presented, with the newest achievements of these large tidal current turbine technologies with their developing histories.
Abstract: Increasing concerns about environmental issues and depletion of fossil resources lead to a global need for producing more clean energy from renewable sources. For coastal areas or some remote islands, marine tidal current energy is a promising renewable power source due to its high predictability. During the last decades, prototypes of various horizontal and vertical axis marine current turbines (MCT) have been developed around the world. Although reviews on MCTs can be found in some state-of-the-art research papers in the last few years, many of the reported MCT projects were only at the planning/design stage when the papers were written. In fact, some projects do not have any further developments during the several years after their first reporting; and others have already upgraded their original designs and adopted up-scaled versions. In this paper, up-to-date information on large tidal turbine projects over 500 kW is focused. The newest achievements of these large tidal current turbine technologies with their developing histories are presented. These technologies represent the industrial solutions for several pre-commercial MCT farm projects in the coming years. New developments in floating MCT technologies are also included. This paper provides a useful background for researchers in the tidal current energy domain and allows them to know the newest developments in large MCT projects around world.

190 citations