N
Norman Arnheim
Researcher at University of Southern California
Publications - 169
Citations - 36340
Norman Arnheim is an academic researcher from University of Southern California. The author has contributed to research in topics: Gene & Germline mutation. The author has an hindex of 69, co-authored 168 publications receiving 35609 citations. Previous affiliations of Norman Arnheim include State University of New York System & Hoffmann-La Roche.
Papers
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Journal ArticleDOI
Enzymatic amplification of beta-globin genomic sequences and restriction site analysis for diagnosis of sickle cell anemia.
Randall Keichi Saiki,Stephen J. Scharf,Fred A. Faloona,Kary B. Mullis,Glenn Thomas Horn,Henry A. Erlich,Norman Arnheim +6 more
TL;DR: Two new methods were used to establish a rapid and highly sensitive prenatal diagnostic test for sickle cell anemia, using primer-mediated enzymatic amplification of specific beta-globin target sequences in genomic DNA, resulting in the exponential increase of target DNA copies.
Patent
Process for amplifying, detecting, and/or-cloning nucleic acid sequences
Kary Banks Mullis,Norman Arnheim,Randall K. Saiki,Henry A. Erlich,Glenn Thomas Horn,Stephen J. Scharf +5 more
TL;DR: In this paper, the authors proposed a method for synthesizing nucleic acid sequences using primers, which can be repeated stepwise or simultaneously and can be replicated as often as desired.
Journal ArticleDOI
Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes.
Concepcion Almoguera,Darryl Shibata,Kathleen Forrester,John Martin,Norman Arnheim,Manuel Perucho +5 more
TL;DR: It is concluded that c-K-ras somatic mutational activation is a critical event in the oncogenesis of most, if not all, human cancers of the exocrine pancreas.
Journal ArticleDOI
Whole genome amplification from a single cell: implications for genetic analysis
TL;DR: W Whole genome amplification beginning with a single cell, or other samples with very small amounts of DNA, has significant implications for multipoint mapping by sperm or oocyte typing and possibly for genetic disease diagnosis, forensics, and the analysis of ancient DNA samples.
Journal ArticleDOI
Involvement of mouse Mlh1 in DNA mismatch repair and meiotic crossing over.
Sean M. Baker,Annemieke W. Plug,Prolla Ta,Bronner Ce,A. C. Harris,Xiang Yao,Christie Dm,Monell C,Norman Arnheim,Allan Bradley,Terry Ashley,R. M. Liskay +11 more
TL;DR: Findings suggest that Mlh1 is involved in DNA mismatch repair and meiotic crossing over in mice deficient in another mismatch repair gene, M lh1.