O.R. Vincent

Bio: O.R. Vincent is an academic researcher from University of Agriculture, Faisalabad. The author has contributed to research in topics: Outbreak & Basic reproduction number. The author has co-authored 1 publications.

Modeling and optimal control of mutated COVID-19 (Delta strain) with imperfect vaccination

Abstract: As people around the world work to stop the COVID-19 pandemic, mutated COVID-19 (Delta strain) that are more contagious are emerging in many places. How to develop effective and reasonable plans to prevent the spread of mutated COVID-19 is an important issue. In order to simulate the transmission of mutated COVID-19 (Delta strain) in China with a certain proportion of vaccination, we selected the epidemic situation in Jiangsu Province as a case study. To solve this problem, we develop a novel epidemic model with a vaccinated population. The basic properties of the model is analyzed, and the expression of the basic reproduction number R0 is obtained. We collect data on the Delta strain epidemic in Jiangsu Province, China from July 20, to August 5, 2021. The weighted nonlinear least square estimation method is used to fit the daily asymptomatic infected people, common infected people and severe infected people. The estimated parameter values are obtained, the approximate values of the basic reproduction number are calculated R0≈1.378 . Through the global sensitivity analysis, we identify some parameters that have a greater impact on the prevalence of the disease. Finally, according to the evaluation results of parameter influence, we consider three control measures (vaccination, isolation and nucleic acid testing) to control the spread of the disease. The results of the study found that the optimal control measure is to dynamically adjust the three control measures to achieve the lowest number of infections at the lowest cost. The research in this paper can not only enrich theoretical research on the transmission of COVID-19, but also provide reliable control suggestions for countries and regions experiencing mutated COVID-19 epidemics.

On fractal-fractional Covid-19 mathematical model

Abstract: In this article, we are studying a Covid-19 mathematical model in the fractal-fractional sense of operators for the existence of solution, Hyers-Ulam (HU) stability and computational results. For the qualitative analysis, we convert the model to an equivalent integral form and investigate its qualitative analysis with the help of iterative convergent sequence and fixed point approach. For the computational aspect, we take help from the Lagrange’s interpolation and produce a numerical scheme for the fractal-fractional waterborne model. The scheme is then tested for a case study and we obtain interesting results.

Backward bifurcation and optimal control in a co-infection model for SARS-CoV-2 and ZIKV

Abstract: In co-infection models for two diseases, it is mostly claimed that, the dynamical behavior of the sub-models usually predict or drive the behavior of the complete models. However, under a certain assumption such as, allowing incident co-infection with both diseases, we have a different observation. In this paper, a new mathematical model for SARS-CoV-2 and Zika co-dynamics is presented which incorporates incident co-infection by susceptible individuals. It is worth mentioning that the assumption is missing in many existing co-infection models. We shall discuss the impact of this assumption on the dynamics of a co-infection model. The model also captures sexual transmission of Zika virus. The positivity and boundedness of solution of the proposed model are studied, in addition to the local asymptotic stability analysis. The model is shown to exhibit backward bifurcation caused by the disease-induced death rates and parameters associated with susceptibility to a second infection by those singly infected. Using Lyapunov functions, the disease free and endemic equilibria are shown to be globally asymptotically stable for R01 , respectively. To manage the co-circulation of both infections effectively, under an endemic setting, time dependent controls in the form of SARS-CoV-2, Zika and co-infection prevention strategies are incorporated into the model. The simulations show that SARS-CoV-2 prevention could greatly reduce the burden of co-infections with Zika. Furthermore, it is also shown that prevention controls for Zika can significantly decrease the burden of co-infections with SARS-CoV-2.

Assessing the impact of SARS-CoV-2 infection on the dynamics of dengue and HIV via fractional derivatives

Abstract: A new non-integer order mathematical model for SARS-CoV-2, Dengue and HIV co-dynamics is designed and studied. The impact of SARS-CoV-2 infection on the dynamics of dengue and HIV is analyzed using the tools of fractional calculus. The existence and uniqueness of solution of the proposed model are established employing well known Banach contraction principle. The Ulam-Hyers and generalized Ulam-Hyers stability of the model is also presented. We have applied the Laplace Adomian decomposition method to investigate the model with the help of three different fractional derivatives, namely: Caputo, Caputo-Fabrizio and Atangana-Baleanu derivatives. Stability analyses of the iterative schemes are also performed. The model fitting using the three fractional derivatives was carried out using real data from Argentina. Simulations were performed with each non-integer derivative and the results thus obtained are compared. Furthermore, it was concluded that efforts to keep the spread of SARS-CoV-2 low will have a significant impact in reducing the co-infections of SARS-CoV-2 and dengue or SARS-COV-2 and HIV. We also highlighted the impact of three different fractional derivatives in analyzing complex models dealing with the co-dynamics of different diseases.

A fractional order model for the co-interaction of COVID-19 and Hepatitis B virus

Abstract: Fractional differential equations are beginning to gain widespread usage in modeling physical and biological processes. It is worth mentioning that the standard mathematical models of integer-order derivatives, including nonlinear models, do not constitute suitable framework in many cases. In this work, a mathematical model for COVID-19 and Hepatitis B Virus (HBV) co-interaction is developed and studied using the Atangana–Baleanu fractional derivative. The necessary conditions of the existence and uniqueness of the solution of the proposed model are studied. The local stability analysis is carried out when the reproduction number is less than one. Using well constructed Lyapunov functions, the disease free and endemic equilibria are proven to be globally asymptotically stable under certain conditions. Employing fixed point theory, the stability of the iterative scheme to approximate the solution of the model is discussed. The model is fitted to real data from the city of Wuhan, China, and important parameters relating to each disease and their co-infection, are estimated from the fitting. The approximate solutions of the model are compared using the integer and fractional order derivatives. The impact of the fractional derivative on the proposed model is also highlighted. The results proven in this paper illustrate that HBV and COVID-19 transmission rates can greatly impact the dynamics of the co-infection of both diseases. It is concluded that to control the co-circulation of both diseases in a population, efforts must be geared towards preventing incident infection with either or both diseases.